Výsledky vyhledávání

Cholesteryl Pullulan Encapsulated TNF-αNanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus

Autor: Mutsuko Taniguchi, Shigeharu Fukuda, Madoka Taniai, Toshio Ariyasu, Daiki Nagatomo, Miho Aga, Tsunetaka Ohta, Harumi Ariyasu

Publikováno v: BioMed Research International, Vol 2015 (2015)
BioMed Research International

We encapsulated tumor necrosis factor-α(TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ba5a879f9fcd2c36d95c6254896f4
https://doi.org/10.1155/2015/471468

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Propolis Enhances Adipocyte Differentiation and Prevents Insulin Resistance in 3T3-L1 cells (Propolis improves insulin resistance in vitro)

Autor: Kanso Iwaki, Shigeyuki Arai, Miho Aga, Tsunetaka Ohta, Emiko Ohashi, Shigeharu Fukuda, Norie Arai, Toshio Ariyasu

Publikováno v: Nippon Shokuhin Kagaku Kogaku Kaishi. 56:31-39

わが国において，脂肪細胞の機能不全を起因の1つとする生活習慣病の増加に対してその予防は急務であり，食品因子からの予防が期待されている．本研究は，プロポリスエキスを対象と

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48e4dbdb961f09b82fc4c7bdff70f89e
https://doi.org/10.3136/nskkk.56.31

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Establishment of Antihuman IFN-α8-Specific Monoclonal Antibodies and Their Application in the Enzyme-Linked Immunosorbent Assay (ELISA)

Autor: Hitomi Ohta, Chie Ushio, Tsunetaka Ohta, Harumi Ariyasu, Shigeharu Fukuda, Masashi Kurimoto, Toshio Ariyasu, Tohru Kayano, Miho Aga

Publikováno v: Journal of Interferon & Cytokine Research. 28:359-366

In the present study, we describe the generation of a series of anti-interferon-alpha8 (IFN-alpha8)-specific monoclonal antibodies (mAbs), their characterization, and the establishment of a sandwich enzyme-linked immunosorbent assay (ELISA) system fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f5c06975f3e13e110b738961d63354
https://doi.org/10.1089/jir.2007.0121

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The Combination of IFN-α2 and IFN-α8 Exhibits Synergistic Antiproliferative Activity on Renal Cell Carcinoma (RCC) Cell Lines Through Increased Binding Affinity for IFNAR-2

Autor: Mutsuko Taniguchi, Toshio Ariyasu, Madoka Taniai, Harumi Ariyasu, Yasuo Tsutsumi, Miho Aga, Shigeto Yamamoto, Yohei Mukai, Tsunetaka Ohta, Chie Ushio, Shigeharu Fukuda, Tadao Tanimoto

Publikováno v: Journal of Interferon & Cytokine Research. 27:517-524

Although there are at least 13 interferon-alpha (IFN-alpha) subtypes in humans, interactions between the subtypes remain unknown. To understand IFN-alpha interactions, we examined the antiproliferative activities and the receptor binding affinities o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98106b195dc2304389393c000c4e1a3b
https://doi.org/10.1089/jir.2007.0155

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Trehalose Protects Cells from Injury Caused by Acids or Cigarette Smoke Constituents (Studies on cytoprotective properties of trehalose)

Autor: Manabu Miyata, Toshio Ariyasu, Chiyo Yoshizane, Tsunetaka Ohta, Shigeharu Fukuda, Miho Aga, Chie Ushio, Shigeyuki Arai

Publikováno v: Nippon Shokuhin Kagaku Kogaku Kaishi. 54:374-378

トレハロースが口腔内細胞を酸やタバコなどの傷害物質から保護するかについて検討した．培養ヒト細胞粘膜モデルに酸またはタバコ煙成分と同時にトレハロースを添加し，傷害の程度�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d87b03275459c784adf5f863a153e6f
https://doi.org/10.3136/nskkk.54.374

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Hypotriglyceridemic effect of the antler-shaped fruiting body of Ganoderma lucidum on the high-fat diet induced hyperlipidemia in Syrian hamsters

Autor: Keiko Hino, Kanso Iwaki, Miho Aga, Masayoshi Kibata, Masashi Kurimoto, Mutsuko Taniguchi, Masao Ikeda, Shin-ichiro Inoue, Tatsuya Ishihara

Publikováno v: Nippon Shokuhin Kagaku Kogaku Kaishi. 52:135-139

近年トリグリセライド (TG) が日本人における心筋梗塞や脳梗塞などの動脈硬化性の疾患のリスクファクターとして大きく注目されている. そこで, 古くから健康増進の目的で用いられてい

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d3fa19107e51e0194e42d3a6936797f
https://doi.org/10.3136/nskkk.52.135

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Inhibition of chlamydia trachomatis growth by human interferon-.ALPHA.: mechanisms and synergistic effect with interferon-.GAMMA. and tumor necrosis factor-.ALPHA

Autor: Keiko Hino, Masao Ikeda, Tatsuya Ishihara, Chie Ushio, Miho Aga, Mutsuko Taniguchi, Kanso Iwaki, Masashi Kurimoto

Publikováno v: Biomedical Research. 26:179-185

We have evaluated the effect of natural human interferon (IFN)-alpha on the growth of chlamydia trachomatis in human epithelial cells in vitro and revealed that IFN-alpha has reduced both growth and infectivity of C. trachomatis. The effect of IFN-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b9de5fcd665a3d6e7a7827f1561687
https://doi.org/10.2220/biomedres.26.179

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The natural plant product tryptanthrin ameliorates dextran sodium sulfate-induced colitis in mice

Autor: Masashi Kurimoto, Tatsuya Ishihara, Mark Micallef, Toshio Kunikata, Shimpei Ushio, Miho Aga, Masao Ikeda, Satomi Koya-Miyata, Kanso Iwaki, Tetsuo Kimoto

Publikováno v: International Immunopharmacology. 2:565-578

The therapeutic effects of tryptanthrin (TRYP), a natural product from the medicinal plant Polygonum tinctorium, were examined in a murine model of inflammatory bowel disease (IBD). Colitis was induced by 5% dextran sodium sulfate (DSS) in drinking w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec06e5513201cc42a7ecb5d471e87fc
https://doi.org/10.1016/s1567-5769(01)00206-5

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Ley glycolipid acts as a co-factor for tumor procoagulant activity

Autor: Haruhiko Inufusa, Shigeto Yamamoto, Tsunetaka Ohta, Motoyuki Suzuki, Masashi Kurimoto, Masayuki Yasutomi, Osamu Ando, Tsuyoshi Hamada, Miho Aga

Publikováno v: International Journal of Cancer. 73:903-909

We have generated a monoclonal antibody (MAb), FS01, which inhibits the procoagulant activity (CCA-1) produced by a human squamous cell carcinoma cell line, LK52. Expression of the antigen recognized by FS01 MAb in various cancer cell lines correlate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9fafc8b80ead4befb5015d24d34dc7f
https://doi.org/10.1002/(sici)1097-0215(19971210)73:6<903::aid-ijc24>3.0.co

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Tryptanthrin inhibits interferon-gamma production by Peyer's patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin

Autor: Kanso Iwaki, Masashi Kurimoto, Shin-ichiro Inoue, Toshio Kunikata, Yasuhiko Takei, Shimpei Ushio, Miho Aga, Masao Ikeda

Publikováno v: Biologicalpharmaceutical bulletin. 26(3)

Tryptanthrin, a biologically active compound found in the medicinal plant Polygonum tinctorium, reportedly has several biological activities. We investigated the effects of tryptanthrin on cytokine production by lymphocytes in response to staphylococ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7824ec277bce4a81b40294aac40d8117
https://pubmed.ncbi.nlm.nih.gov/12612449

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