Zobrazeno 1 - 2
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pro vyhledávání: '"Mihir Pershad"'
Autor:
Mihir Pershad, Sharon L. Campbell, Peter M. Thompson, Hyunna T. Lee, Laura Y. Kim, Gregory M. Alushin
Publikováno v:
Journal of Molecular Biology. 428:10-25
Vinculin is an essential adhesion protein that links membrane-bound integrin and cadherin receptors through their intracellular binding partners to filamentous actin, facilitating mechanotransduction. Here we present an 8.5-Å-resolution cryo-electro
Role of PIP2-Dependent Membrane Interactions in Vinculin Activation, Motility and Force Transmission
Autor:
Srinivas Ramachandran, Caitlin E. Tolbert, Sharon L. Campbell, Peter M. Thompson, Nikolay V. Dokholyan, Clare M. Waterman, Mihir Pershad, Lindsay B. Case, Keith Burridge
Publikováno v:
Biophysical Journal. 110(3)
Vinculin is an essential and abundant cytoskeletal protein localized to focal adhesions and cell-cell contacts, where it participates in the linkage of transmembrane receptors to the actin cytoskeleton to control cell survival and migration. Loss of