Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mihir Metkar"'
Autor:
Alicia A. Bicknell, David W. Reid, Marissa C. Licata, Adriana K. Jones, Yi Min Cheng, Mengying Li, Chiaowen Joyce Hsiao, Christopher S. Pepin, Mihir Metkar, Yevgen Levdansky, Brian R. Fritz, Elizaveta A. Andrianova, Ruchi Jain, Eugene Valkov, Caroline Köhrer, Melissa J. Moore
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114098- (2024)
Summary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more
Externí odkaz:
https://doaj.org/article/7b3fb817ec414bcf9bdcba69344c3e0c
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq,
Externí odkaz:
https://doaj.org/article/8b91d004d3a84adea8c40fb190b994de
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Genome Biology
Genome Biology
BackgroundAlternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq, however,
Additional file 4. Includes peer review history.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e9d0e1d0242843e5a3c118f762a652
Autor:
James D. Chappell, Elisabeth Narayanan, Kaitlyn M. Morabito, Alexandra Schäfer, Laura J. Stevens, Yi Zhang, Stephen D. Schmidt, Kevin W. Bock, Isabella Renzi, Ian N. Moore, Dario Garcia-Dominguez, Catherine Liu, Kizzmekia S. Corbett, Christine A. Shaw, Cynthia T. Ziwawo, Mark R. Denison, Lauren A. Chang, Lingshu Wang, Sunny Himansu, Mihir Metkar, Guillaume Stewart-Jones, Seyhan Boyoglu-Barnum, Daniel Wrapp, Kendra Gully, Geoffrey B. Hutchinson, Kwanyee Leung, Wing-Pui Kong, Emily Phung, Eun Sung Yang, Mahnaz Minai, Rebecca A. Gillespie, Angela Woods, Jason S. McLellan, Sarah R. Leist, Mark K. Louder, Sayda Elbashir, David R. Martinez, Darin K. Edwards, Bianca M. Nagata, Kenneth H. Dinnon, John R. Mascola, Martha Nason, Hamilton Bennett, Rebecca J. Loomis, Ande West, Andrea Carfi, Olubukola M. Abiona, Barney S. Graham, Anthony T. DiPiazza, Wei Shi, Ralph S. Baric, Nicole A. Doria-Rose, Kapil Bahl, Nedim Emil Altaras, Nianshuang Wang, Tracy J. Ruckwardt, Ethan J. Fritch, Vladimir Presnyak, LingZhi Ma
Publikováno v:
bioRxiv
Nature
Nature
Summary A severe acute respiratory syndrome coronavirus (SARS-CoV-2) vaccine is needed to control the global coronavirus infectious disease (COVID-19) public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc8dc81b2d35d6bf33db624622f8357
https://europepmc.org/articles/PMC7301911/
https://europepmc.org/articles/PMC7301911/
Autor:
Eun Sung Yang, Cuiping Liu, Nicole A. Doria-Rose, Dario Garcia-Dominguez, Hamilton Bennett, Nianshuang Wang, Kapil Bahl, Nedim Emil Altaras, Kaitlyn M. Morabito, Alexandra Schäfer, Kevin W. Bock, John R. Mascola, Kai Wu, Guillaume Stewart-Jones, Ethan J. Fritch, Kizzmekia S. Corbett, Kwanyee Leung, Mahnaz Minai, Ling Zhi Ma, Andrea Carfi, Christine A. Shaw, Barney S. Graham, Mark K. Louder, Anthony T. DiPiazza, Wing Pui Kong, Stephen D. Schmidt, Yi Zhang, Sayda Elbashir, Ande West, Gabriela S. Alvarado, Wei Shi, Isabella Renzi, Ralph S. Baric, Elisabeth Narayanan, Mihir Metkar, Bianca M. Nagata, Tracy J. Ruckwardt, Rebecca J. Loomis, Martha Nason, Darin K. Edwards, Cynthia T. Ziwawo, Sunny Himansu, Emily Phung, Seyhan Boyoglu-Barnum, Laura J. Stevens, Kendra Gully, Carole Henry, Olubukola M. Abiona, Angela Woods, Lauren A. Chang, Sarah R. Leist, Geoffrey B. Hutchinson, Daniel Wrapp, Kenneth H. Dinnon, James D. Chappell, Lingshu Wang, Vlad Presnyak, Rebecca A. Gillespie, Jason S. McLellan, David R. Martinez, Ian N. Moore, Mark R. Denison
Publikováno v:
Nature
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb9dfcf84b0b1edbdebf8300c5160b8
BackgroundAlternative splicing (AS), which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing AS pathways cannot be determined by traditional RNA-Seq, however, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384fb9cac9570a4fadb53e86aafea139
Autor:
Job Dekker, Bryan R. Lajoie, Melissa J. Moore, Maxim Imakaev, Mihir Metkar, Hakan Ozadam, Leonid A. Mirny
SummaryCompared to noncoding RNAs (ncRNAs) such as rRNAs and ribozymes, for which high resolution structures abound, little is known about the tertiary structures of mRNAs. In eukaryotic cells, newly made mRNAs are packaged with proteins in highly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170efd199f6a4b9b6af494e300172ba0
https://doi.org/10.1101/278747
https://doi.org/10.1101/278747
Autor:
Mihir Metkar, Maxim Imakaev, Leonid A. Mirny, Bryan R. Lajoie, Hakan Ozadam, Job Dekker, Melissa J. Moore
Publikováno v:
PMC
Compared to noncoding RNAs (ncRNAs), such as rRNAs and ribozymes, for which high-resolution structures abound, little is known about the tertiary structures of mRNAs. In eukaryotic cells, newly made mRNAs are packaged with proteins in highly compacte