Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mihir Khambete"'
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 377 (2023)
Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes have been extensively studied for bacterial pathogens such as Escherichia coli and
Externí odkaz:
https://doaj.org/article/8babb566a4cd4dde8eeca6a5684bf2d6
Publikováno v:
Chemical Biology & Drug Design. 101:453-468
The increasing incidence of Alzheimer's disease (AD) coupled with the lack of therapeutics to address the underlying pathology of the disease has necessitated the need for exploring newer targets. Calcium dysregulation represents a relatively newer t
Autor:
Mariam S. Degani, Swati Vyas, Mihir Khambete, Ronak B. Gudhka, Shail Panchamia, Vandana B. Patravale
Publikováno v:
Drug Delivery and Translational Research. 10:1085-1094
Controlling structurally defined properties of drug-bound macromolecules such as surface adhesion and interaction with endogenous proteins in the surrounding environment using prior data from computer-assisted simulation can be of great use in design
Autor:
Ronak B. Gudhka, Mariam S. Degani, Vandana B. Patravale, Shail Panchamia, Mihir Khambete, Swati Vyas
Publikováno v:
Drug Delivery and Translational Research. 10:1076-1084
Indigenous polymers have functional implications in biomedicine due to the presence of an inherent favorable structural architecture that supports hydrogel formation. In this study, we present the molecular level characterization of xyloglucan hydrog
Therapeutic potential of ferulic acid and its derivatives in Alzheimer's disease-A systematic review
Publikováno v:
Chemical biologydrug designREFERENCES. 98(5)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily caused by accumulation of amyloid-beta (Aβ) peptide extracellularly and neurofibrillary tangles intracellularly. Recently, it has been shown that oxidative stress and mit
Autor:
Arundhati Maitra, Tulika Munshi, Mihir Khambete, Antima Gupta, Sanjib Bhakta, Mariam S. Degani, Neha Agre
Publikováno v:
Chemical Biology & Drug Design. 95:192-199
We report the biological evaluation of 5-(5-nitrothiophen-2-yl)-4,5-dihydro-1H-pyrazole derivatives against bacteria, eukaryotic cell lines and the assessment of their mechanisms of action to determine their prospects of being developed into potent a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1999-2007
With the increasing number of cases of latent and drug resistant tuberculosis, there is an urgent need to develop new, potent molecules capable of combating this deadly disease. Molecules containing oxadiazoles are one such class that could be consid
Publikováno v:
Drug Metabolism and Drug Interactions. 35
Objectives Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease in which one of the most prominent pathological features is accumulation of amyloid (Aβ) plaques. This occurs due to the process of aggregation from monomer
Autor:
Harish Kundaikar, Mukti Kanta Ray, Mariam S. Degani, Archana Raju, Sachin L. Lonkar, Mihir Khambete
Publikováno v:
Chemical biologydrug design. 93(1)
We report the design-synthesis of several nitrothiophene containing molecules as antituberculosis agents. The molecules were designed on the basis of previously reported nitrofuran molecules in our laboratory, and the α,β-unsaturated linker was mod
Publikováno v:
Phytotherapy Research. 29:1646-1651
With the view of exploring phytochemicals as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors, known plant polyphenols from various classes were subjected to detailed docking studies. From this in-silico screening, seven polyphenol