Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Mihir D Wechalekar"'
Autor:
Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao
Publikováno v:
RMD Open, Vol 8, Iss 2 (2022)
Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5− T cells, termed T peripheral helper (Tph) cells, which driv
Externí odkaz:
https://doaj.org/article/f7fc10303c3b466ab3977cd24072ecdf
Autor:
Susanna Proudman, Sonja Klebe, William Murray-Brown, Tom D Wilsdon, Helen Weedon, Shawgi Sukumaran, Jennifer G Walker, Malcolm D Smith, Mihir D Wechalekar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Immune checkpoint inhibitors (ICIs) are associated with rheumatic and musculoskeletal immune-related adverse events (irAEs) in 5%–20% of patients. Currently, patients refractory to corticosteroids and conventional disease-modifying antir
Externí odkaz:
https://doaj.org/article/3ff420a1c1334dfdbe3137f84bc8f0e1
Autor:
Yanxia Guo, Alice M Walsh, Mary Canavan, Mihir D Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew Loza, Carl Orr, Trudy McGarry, Michele Bombardieri, Frances Humby, Susanna M Proudman, Costantino Pitzalis, Malcolm D Smith, Joshua R Friedman, Ian Anderson, Loui Madakamutil, Douglas J Veale, Ursula Fearon, Sunil Nagpal
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192704 (2018)
Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multip
Externí odkaz:
https://doaj.org/article/0245b0b04ea640cd937145e897e7feff
Autor:
Alice M Walsh, Mihir D Wechalekar, Yanxia Guo, Xuefeng Yin, Helen Weedon, Susanna M Proudman, Malcolm D Smith, Sunil Nagpal
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183928 (2017)
This study sought to investigate the genome-wide transcriptional effects of a combination of disease modifying anti-rheumatic drugs (tDMARD; methotrexate, sulfasalazine and hydroxychloroquine) in synovial tissues obtained from early rheumatoid arthri
Externí odkaz:
https://doaj.org/article/76f9ed5f606142999ff644b601a6cae9
Autor:
Mihir D. Wechalekar, Lin-Pierre Zhao, Monika M. Kutyna, Lih En Hong, Joule Li, Kevin Hung, Hamish S. Scott, Anna Brown, Christopher C. Hahn, Karin Kassahn, Dariusz Ladon, David T. Yeung, Daniel Thomas, Mrinal Patnaik, Susanna Proudman, Lionel Ades, Mithun V. Shah, Chung H. Kok, Devendra K. Hiwase
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/8a363b1a155c4c5b8cf3f98ef635b878
Autor:
Mihir D Wechalekar
Publikováno v:
Journal of Mahatma Gandhi Institute of Medical Sciences, Vol 19, Iss 1, Pp 9-11 (2014)
Externí odkaz:
https://doaj.org/article/81bfbe7217314b38ab6e1cb15de1c91a
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/51cd8dc2373a44ed8258ae5134515973
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rheumatoid arthritis (RA) is one of the most prevalent autoimmune inflammatory conditions, and while the mechanisms driving pathogenesis are yet to be completely elucidated, self-reactive T cells and immune checkpoint pathways have a clear role. In t
Externí odkaz:
https://doaj.org/article/52239b056eac4c43910a6807c8275384
Autor:
Katie Lowe, Annabelle Small, Qingxuan Song, Ling-Yang Hao, William Murray-Brown, Susanna Proudman, Malcolm D. Smith, Sunil Nagpal, Mihir D. Wechalekar
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known about their functional role in the pathogenesis of early RA. To address this, we inves
Externí odkaz:
https://doaj.org/article/c8beaac6c2f84d4dbdb177179193cb1d
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/8ddea8121b154b87add41b75fdcdae65