Výsledky vyhledávání - "Mihaly V Toth"

Preparation and analytical data of some unusual amino acid derivatives used in peptide syntheses (I)

Autor: Kálmán Kovács, Csaba Somlai, Lajos Baláspiri, Mihaly V. Toth

Publikováno v: International Journal of Peptide and Protein Research. 26:1-4

The preparation methods, yields and some analytical data of benzyloxycarbonyl-, t-butyloxycarbonyl- and 9-fluorenylmethyloxycarbonyl-amino acid derivatives of several unusual amino acids are given and tabulated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d489ed55da838f2898f8cd630aadf4f8
https://doi.org/10.1111/j.1399-3011.1985.tb03171.x

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Syntheses of new conformationally constrainedS-[2-[(1-iminoethyl)amino] ethyl]homocysteine derivatives as potential nitric oxide synthase inhibitors

Autor: William M. Moore, Barnett S. Pitzele, Timothy J. Hagen, Kam F. Fok, Dale P. Spangler, Margaret L. Grapperhaus, Pamela T. Manning, Jeffrey A. Scholten, Lijuan J. Wang, James A. Sikorski, Mihaly V. Toth, Gina M. Jerome

Publikováno v: Heteroatom Chemistry. 13:77-83

The efficient syntheses of two new types of conformationally constrained S-[2-[(1-iminoethyl)amino]ethyl]homocysteine derivatives, 1-amino-3-[2[(1-iminoethyl)amino]ethylthio]cyclobutane carboxylic Acid (5) and (4S)-4-[[2-[(1-Iminoethyl)amino]ethyl]th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f689551dcf694538273cbe2e3c1159aa
https://doi.org/10.1002/hc.1109

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HIV-1 protease inhibitors: Ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs

Autor: Aime Marinier, Mihaly V. Toth, Garland R. Marshall, Kathryn Houseman, Richard A. Mueller

Publikováno v: Bioorganic & Medicinal Chemistry. 2:919-925

HIV protease is a member of the aspartic proteinase family of proteolytic enzymes which include pepsin and renin. In contrast to the enhanced affinity seen with renin and pepsin upon conversion of the transition-state isostere, ketomethylene, to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dc6e87655f468b786a899b17527371
https://doi.org/10.1016/s0968-0896(00)82041-6

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Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism

Autor: Jeffrey I. Gordon, Emily Jackson-Machelski, Mihaly V. Toth, Mcwherter Charles A, Warren J. Rocque, David A. Rudnick

Publikováno v: Proceedings of the National Academy of Sciences. 90:1087-1091

Nmt1p (EC 2.3.1.97) catalyzes the transfer of myristate (C14:0) from coenzyme A to the N-terminal glycine residue of a variety of eukaryotic cellular and viral proteins. Our recent studies of the 455-amino acid Saccharomyces cerevisiae acyltransferas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d5c457bc59464df29282f0594e1c2e
https://doi.org/10.1073/pnas.90.3.1087

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Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase

Autor: Ronald Keith Webber, William M. Moore, Pamela T. Manning, Sue Metz, Mihaly V. Toth, Alan E. Moormann, Gina M. Jerome, Donald W. Hansen, Christine Kornmeier, Barnett S. Pitzele

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2651-2653

The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9727b68b1b644f4201f4f9d03c3d37
https://doi.org/10.1016/s0960-894x(01)00523-6

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ChemInform Abstract: Selective Heterocyclic Amidine Inhibitors of Human Inducible Nitric Oxide Synthase

Autor: Alan E. Moormann, Donald W. Hansen, Gina M. Jerome, Sue Metz, Barnett S. Pitzele, Ronald Keith Webber, William M. Moore, Mihaly V. Toth, Pamela T. Manning, Christine Kornmeier

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b3946ff79ba2f2c48bff4fa5da1fe71
https://doi.org/10.1002/chin.200201177

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Conformational mimicry. 3. Synthesis and incorporation of 1,5-disubstituted tetrazole dipeptide analogs into peptides with preservation of chiral integrity: bradykinin

Autor: Janusz Zabrocki, Mihaly V. Toth, James B. Dunbar, Keith W. Marshall, Garland R. Marshall

Publikováno v: The Journal of Organic Chemistry. 57:202-209

The simple addition of the organic base,quinoline,to the reaction with PCl 5 when generating an imidoyl chloride from the amide was effective in reducing racemization of the N-terminal amino acid residue of the protected tetrazole dipeptide to mimina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63868e4b70b174f32e374f4d7e888d5d
https://doi.org/10.1021/jo00027a038

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Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease

Autor: Stephen B. H. Kent, Jeremy Green, Daniel H. Rich, Mihaly V. Toth, Garland R. Marshall

Publikováno v: Journal of Medicinal Chemistry. 33:1285-1288

We report the synthesis of hydroxyethylamine dipeptidyl isosteres that were designed to mimic the tetrahedral intermediate for hydrolysis of Tyr-Pro, one of the partial substrate sequences cleaved by HIV protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b871f8bfc626f4ba20ddeb91488fd6
https://doi.org/10.1021/jm00167a003

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