Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Mihajlo, Novakovic"'
1
Akademický článek
Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility
Autor: Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F. Damberger, Christophe Maris, Esteban Finol, Chris P. Sarnowski, Joachim Kohlbrecher, Timothy J. Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric H.-T. Allain
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of defined domains interspersed with flexible, intrinsically disordered regions. Determining the structure of ribonucleoprotein (RNP) complexes involving s
Externí odkaz: https://doaj.org/article/6ecfd082137440199e61e0254d4f1997
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2
Akademický článek
Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids
Autor: Mihajlo Novakovic, Ēriks Kupče, Andreas Oxenfarth, Marcos D. Battistel, Darón I. Freedberg, Harald Schwalbe, Lucio Frydman
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Here, the authors present an approach that enhances the sensitivity of basic 2D biomolecular NMR experiments like NOESY and TOCSY, when carried out in polysaccharides, proteins and nucleic acids. This method combines principles associated to quantum
Externí odkaz: https://doaj.org/article/706ccc8d99ec4f9aa4ca1298fa4b223f
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3
A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2
Autor: Giacomo Padroni, Maria Bikaki, Mihajlo Novakovic, Antje C. Wolter, Simon H. Rüdisser, Alvar D. Gossert, Alexander Leitner, Frederic H.-T Allain
Publikováno v: Nucleic Acids Research, 51 (9)
The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggabilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf60958a131b4e8fd2d201a1a1706843
https://doi.org/10.1093/nar/gkad195
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4
The Incorporation of Labile Protons into Multidimensional NMR Analyses: Glycan Structures Revisited
Autor: Marcos D. Battistel, Hugo F. Azurmendi, Lucio Frydman, Darón I. Freedberg, Mihajlo Novakovic, Maria Grazia Concilio
Publikováno v: Journal of the American Chemical Society
Glycan structures are often stabilized by a repertoire of hydrogen-bonded donor/acceptor groups, revealing longer-lived structures that could represent biologically relevant conformations. NMR provides unique data on these hydrogen-bonded networks fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661e08cc179d07b605d04c28ea7e9bb
https://doi.org/10.1021/jacs.1c04512
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5
A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR
Autor: Mihajlo Novakovic, Daniel Hymon, Gregory L. Olsen, Lucio Frydman, György Pintér, Harald Schwalbe, Boris Fürtig
Publikováno v: Proc Natl Acad Sci U S A
NMR sensitivity-enhancement methods involving hyperpolarized water could be of importance for solution-state biophysical investigations. Hyperpolarized water (HyperW) can enhance the 1 H NMR signals of exchangeable sites by orders of magnitude over t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755a0237db390c758190b781580662e3
https://doi.org/10.1073/pnas.1916956117
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9
The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile
Autor: Jihyun, Kim, Mihajlo, Novakovic, Sundaresan, Jayanthi, Adonis, Lupulescu, Ēriks, Kupče, J Tassilo, Grün, Klara, Mertinkus, Andreas, Oxenfarth, Harald, Schwalbe, Lucio, Frydman
Publikováno v: Chemphyschem : a European journal of chemical physics and physical chemistry. 23(4)
Hadamard encoded saturation transfer can significantly improve the efficiency of NOE-based NMR correlations from labile protons in proteins, glycans and RNAs, increasing the sensitivity of cross-peaks by an order of magnitude and shortening experimen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b6b8b6e866399a425370e289238c954
https://pubmed.ncbi.nlm.nih.gov/34968005
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