Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory.

Autor: Valencia, R. G.¹ (AUTHOR), Mihailovska, E.¹ (AUTHOR), Winter, L.^1,2 (AUTHOR), Bauer, K.¹ (AUTHOR), Fischer, I.¹ (AUTHOR), Walko, G.¹ (AUTHOR), Jorgacevski, J.^3,4 (AUTHOR), Potokar, M.^3,4 (AUTHOR), Zorec, R.^3,4 (AUTHOR), Wiche, G.¹ (AUTHOR) gerhard.wiche@univie.ac.at

Publikováno v: Neuropathology & Applied Neurobiology. Feb2021, Vol. 47 Issue 1, p73-95. 23p.

Combinatorial Vaccine against Complement Factor C5a and Amyloid Beta: A New Therapeutic Approach in Alzheimers Disease

Autor: linger C, Staffler G, Galabova G, Mihailovska E, ler M

Publikováno v: Journal of Clinical & Cellular Immunology.

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by neuronal loss due to amyloid beta (Aβ) aggregations, neurofibrillary tangles, and prominent neuroinflammation. Inflammatory processes in AD primarily occur in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::285c7163d1716e62beec65f41a5a43fd
https://doi.org/10.4172/2155-9899.1000487

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Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.

Autor: Mihailovska E; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria., Raith M; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria., Valencia RG; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria., Fischer I; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria., Al Banchaabouchi M; Preclinical Phenotyping Facility, Campus Science Support Facilities, 1030 Vienna, Austria., Herbst R; Center for Brain Research and Institute of Immunology, Medical University of Vienna, 1030 Vienna, Austria., Wiche G; Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria gerhard.wiche@univie.ac.at.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2014 Dec 15; Vol. 25 (25), pp. 4130-49. Date of Electronic Publication: 2014 Oct 15.