Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mihail Todiraş"'
Autor:
Lukas Zanders, Melanie Kny, Alexander Hahn, Sibylle Schmidt, Sebastian Wundersitz, Mihail Todiras, Ines Lahmann, Arnab Bandyopadhyay, Tobias Wollersheim, Lars Kaderali, Friedrich C. Luft, Carmen Birchmeier, Steffen Weber‐Carstens, Jens Fielitz
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 713-727 (2022)
Abstract Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and
Externí odkaz:
https://doaj.org/article/f560140054434db8868ed4b786ec405c
Autor:
Katharina Busch, Melanie Kny, Nora Huang, Tilman E. Klassert, Magdalena Stock, Alexander Hahn, Sebastian Graeger, Mihail Todiras, Sibylle Schmidt, Bishwas Chamling, Michael Willenbrock, Stefan Groß, Doreen Biedenweg, Arnd Heuser, Claus Scheidereit, Christian Butter, Stephan B. Felix, Oliver Otto, Friedrich C. Luft, Hortense Slevogt, Jens Fielitz
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1653-1668 (2021)
Abstract Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting Nlrp3 woul
Externí odkaz:
https://doaj.org/article/c6eda1ee71e947879615bcafea821786
Autor:
Alexander Hahn, Melanie Kny, Cristina Pablo‐Tortola, Mihail Todiras, Michael Willenbrock, Sibylle Schmidt, Katrin Schmoeckel, Ilka Jorde, Marcel Nowak, Ernst Jarosch, Thomas Sommer, Barbara M. Bröker, Stephan B. Felix, Claus Scheidereit, Steffen Weber‐Carstens, Christian Butter, Friedrich C. Luft, Jens Fielitz
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 103-119 (2020)
Abstract Background Critically ill patients frequently develop muscle atrophy and weakness in the intensive‐care‐unit setting [intensive care unit‐acquired weakness (ICUAW)]. Sepsis, systemic inflammation, and acute‐phase response are major r
Externí odkaz:
https://doaj.org/article/bd0b836c9c4742d59eda00dff324776d
Autor:
Giulia Sbrini, Paola Brivio, Polina Mineva Peeva, Mihail Todiras, Michael Bader, Natalia Alenina, Francesca Calabrese
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Alterations in serotonergic transmission have been related to a major predisposition to develop psychiatric pathologies, such as depression. We took advantage of tryptophan hydroxylase (TPH) 2 deficient rats, characterized by a complete absence of se
Externí odkaz:
https://doaj.org/article/9f14fe125055426c83c9703d7907b743
Autor:
Anne Järve, Fatimunnisa Qadri, Mihail Todiras, Shirley Schmolke, Natalia Alenina, Michael Bader
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Experimental spinal cord injury (SCI) causes a morphological and functional deterioration of the heart, in which the renin–angiotensin system (RAS) might play a role. The recently discovered non-canonical axis of RAS with angiotensin-(1–7) and it
Externí odkaz:
https://doaj.org/article/f207d01beffb4fbdb5446767bcfccc92
Autor:
Anne Järve, Mihail Todiras, Melanie Kny, Falk I. Fischer, Jan F. Kraemer, Niels Wessel, Ralph Plehm, Jens Fielitz, Natalia Alenina, Michael Bader
Publikováno v:
Frontiers in Physiology, Vol 9 (2019)
Spinal cord injury (SCI) above mid-thoracic levels leads to autonomic dysfunction affecting both the cardiovascular system and thermoregulation. The renin-angiotensin system (RAS) which is a potent regulator of blood pressure, including its novel ben
Externí odkaz:
https://doaj.org/article/c76b4f1b620b414d99d9aba2b2c0fb37
Autor:
Carlos C. Barros, Ines Schadock, Gabin Sihn, Franziska Rother, Ping Xu, Elena Popova, Irina Lapidus, Ralph Plehm, Arnd Heuser, Mihail Todiras, Sebastian Bachmann, Natalia Alenina, Ronaldo C. Araujo, Joao B. Pesquero, Michael Bader
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied. A new transgenic animal model
Externí odkaz:
https://doaj.org/article/c038d9e39846446c9faa5855c158d282
Autor:
Paola Brivio, Giulia Sbrini, Polina Peeva, Mihail Todiras, Michael Bader, Natalia Alenina, Francesca Calabrese
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Dysregulations of the central serotoninergic system have been implicated in several psychopathologies, characterized by different susceptibility between males and females. We took advantage of tryptophan hydroxylase 2 (TPH2) deficient rats, lacking s
Externí odkaz:
https://doaj.org/article/f3af7ac4c2f1428080cb6e4d5db47d7a
Autor:
Luiza A Rabelo, Mihail Todiras, Valéria Nunes-Souza, Fatimunnisa Qadri, István András Szijártó, Maik Gollasch, Josef M Penninger, Michael Bader, Robson A Santos, Natalia Alenina
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0150255 (2016)
Accumulating evidence indicates that angiotensin-converting enzyme 2 (ACE2) plays a critical role in cardiovascular homeostasis, and its altered expression is associated with major cardiac and vascular disorders. The aim of this study was to evaluate
Externí odkaz:
https://doaj.org/article/8a5a6456838c46fdb0a4f58f516c7a02
Autor:
Katarina Kotnik, Elena Popova, Mihail Todiras, Marcelo A Mori, Natalia Alenina, Jost Seibler, Michael Bader
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5124 (2009)
The rat is an important animal model in biomedical research, but gene targeting technology is not established for this species. Therefore, we aimed to produce transgenic knockdown rats using shRNA technology and pronuclear microinjection. To this pur
Externí odkaz:
https://doaj.org/article/788b7714876544118cfc35c405df8dfb