Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mihai L Azoitei"'
Autor:
Olivia Swanson, Joshua S Martin Beem, Brianna Rhodes, Avivah Wang, Maggie Barr, Haiyan Chen, Robert Parks, Kevin O Saunders, Barton F Haynes, Kevin Wiehe, Mihai L Azoitei
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011401 (2023)
A major goal for the development of vaccines against rapidly mutating viruses, such as influenza or HIV, is to elicit antibodies with broad neutralization capacity. However, B cell precursors capable of maturing into broadly neutralizing antibodies (
Externí odkaz:
https://doaj.org/article/be597b732e5e4ca1bf7194acc6fce0f5
Autor:
Dapeng Li, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, Kevin Wiehe, Richard M. Scearce, Maggie Barr, Zekun Mu, Robert Parks, Max Quastel, Robert J. Edwards, Yunfei Wang, Wes Rountree, Kevin O. Saunders, Guido Ferrari, Persephone Borrow, E. Yvonne Jones, S. Munir Alam, Mihai L. Azoitei, Geraldine M. Gillespie, Andrew J. McMichael, Barton F. Haynes
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.
Externí odkaz:
https://doaj.org/article/059bf3a2d5d44706ba2a0a0de0b49e26
Autor:
Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Brianna Rhodes, Pranay Vure, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B Walter, Rob Parks, Maggie Barr, Qi Yin, Derek W. Cain, Kevin Wiehe, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
bioRxiv
Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which can readily mutate to escape acquired immunity. Other regions in the spike S2 subunit, such as the fusion peptide and the stem helix, are highly c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060779cf22deff8bea8e1ed503b1bfcd
https://doi.org/10.1101/2023.02.27.530277
https://doi.org/10.1101/2023.02.27.530277
Autor:
Jinqi Ren, Gaudenz Danuser, Klaus M. Hahn, Mihai L. Azoitei, Jaewon Huh, Marco Vilela, Daniel J. Marston, George Glekas, John Sondek
Publikováno v:
Nature chemical biology
Here we generate fluorescence resonance energy transfer biosensors for guanine exchange factors (GEFs) by inserting a fluorescent protein pair in a structural 'hinge' common to many GEFs. Fluorescent biosensors can map the activation of signaling mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5234d2e7ee2bc25b034d05b827cded17
http://europepmc.org/articles/PMC7388658
http://europepmc.org/articles/PMC7388658
Autor:
Eric Betzig, Wesley R. Legant, Denis Tsygankov, Ellen C. O’Shaughnessy, Klaus M. Hahn, Keith Burridge, Timothy C. Elston, Erika S. Wittchen, John M. Heddleston, Orrin J. Stone, David Adalsteinsson, Paul K. LaFosse, Mihai L. Azoitei, Teng-Leong Chew
Publikováno v:
The Journal of Cell Biology
O’Shaughnessy et al. present new software called ImageTank to process lattice light-sheet images of FRET biosensors. ImageTank efficiently handles large 3D datasets and includes tools for visualization and analysis. Its capabilities are demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5df207296331c8a1aa34eeb3992085c
https://doi.org/10.1083/jcb.201903019
https://doi.org/10.1083/jcb.201903019
Autor:
Daniel J. Marston, Philippe Roudot, Mitsu Ikura, Timothy A. Daugird, Christopher B. Marshall, Robert Rottapel, Jungsik Noh, María José Sandí, Sidney L. Lisanza, Klaus M. Hahn, John Sondek, Gaudenz Danuser, Mihai L. Azoitei
Publikováno v:
The Journal of Cell Biology
Azoitei, Noh, et al. engineer fluorescent biosensors to measure activation at the subcellular level and with subsecond kinetics of GEF-H1, a Rho GTPase that regulates cytoskeletal dynamics. In combination with computational image time series analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d9550692c61b49da079f9fbdaca28a
http://europepmc.org/articles/PMC6719461
http://europepmc.org/articles/PMC6719461
Autor:
Barton F. Haynes, Esther J. Lee, Mark G. Lewis, Laura L. Sutherland, Robert J. Edwards, Kevin O. Saunders, S. Munir Alam, R. Wes Rountree, Mark A. Tomai, Kartik Manne, Priyamvada Acharya, Anyway B. Kapingidza, C. Todd DeMarco, Sophie M. C. Gobeil, Maggie Barr, Robert A. Seder, Matthew Gagne, Robert Parks, Rachel L. Spreng, Dapeng Li, Gregory D. Sempowski, Aja Sanzone, Hanne Leth Andersen, Ralph S. Baric, Christopher B. Fox, Mihai L. Azoitei, Elizabeth Petzold, Thomas N. Denny, Longping V. Tse, Christopher W. Woods, David C. Montefiori, Drew Weissman, Norbert Pardi, Daniel C. Douek, Haiyan Chen, Katayoun Mansouri, David R. Martinez, Ian N. Moore, Trevor Scobey, Thomas H. Oguin, Kevin Wiehe, Madison Berry, Fangping Cai
Publikováno v:
bioRxiv
SUMMARYBetacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7849ac2671cd4a5cdd07c8df6f443fbc
https://doi.org/10.1101/2021.02.17.431492
https://doi.org/10.1101/2021.02.17.431492
Autor:
Kevin Wiehe, Shi-Mao Xia, Brianna Rhodes, Barton F. Haynes, Robert Parks, Olivia Swanson, Aja Sanzone, Mattia Bonsignori, Bob C. Lin, Avivah Wang, Kevin O. Saunders, Mihai L. Azoitei, Melissa Cooper, Mark K. Louder, Nicole A. Doria-Rose
SummaryElicitation of broadly neutralizing antibodies (bnAbs) by an HIV vaccine will involve priming the immune system to activate antibody precursors, followed by boosting immunizations to select for antibodies with functional features required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395fd7857a0c286b6d3ff29bd4cbd497
https://doi.org/10.1101/2021.01.04.425252
https://doi.org/10.1101/2021.01.04.425252
Autor:
Hanne Leth Andersen, Hana Golding, Matthew Gagne, Robert J. Edwards, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei, Kartik Manne, Gregory D. Sempowski, Dapeng Li, Thomas N. Denny, Esther J. Lee, C. Todd DeMarco, Robert A. Seder, Elizabeth Petzold, Priyamvada Acharya, Surender Khurana, Mahnaz Minai, Mark G. Lewis, Trevor Scobey, R. Wes Rountree, Sophie M. C. Gobeil, Anyway B. Kapingidza, Thomas H. Oguin, Christopher W. Woods, Madison Berry, Rachel L. Spreng, Drew Weissman, Juanjie Tang, Mark A. Tomai, Christopher B. Fox, Ian N. Moore, Laura L. Sutherland, Kevin Wiehe, Ralph S. Baric, Robert Parks, Fangping Cai, Katayoun Mansouri, Norbert Pardi, Kevin W. Bock, Longping V. Tse, Daniel C. Douek, David R. Martinez, David C. Montefiori, Bianca M. Nagata, Aja Sanzone, Maggie Barr, S. Munir Alam, Haiyan Chen
Publikováno v:
Signal Transduction and Targeted Therapy
Nature
Nature
Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (SARS-CoV-2)1-4. Vaccines that elicit protective immunity against SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21d8feaf8225d5d115fd14e1099ae83
Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity
Autor:
Dapeng Li, Karl Harlos, Zekun Mu, Wes Rountree, Olivia Swanson, Guido Ferrari, E. Yvonne Jones, Robert Parks, Simon Brackenridge, Persephone Borrow, Geraldine M. Gillespie, Barton F. Haynes, Max Quastel, S. Munir Alam, L.C. Walters, Maggie Barr, Richard M. Scearce, Derek W. Cain, Robert J. Edwards, Kevin O. Saunders, Andrew J. McMichael, Daniel Rozbesky, Kevin Wiehe, Yunfei Wang, Mihai L. Azoitei
HLA-E is a non-classical class Ib molecule that has limited polymorphism and binds HLA class Ia leader peptides (VL9). HLA-E-VL9 complexes interact with the natural killer (NK) cell receptors NKG2A-C/CD94 and regulate NK cell-mediated cytotoxicity. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75bf409ea0eea689bb70af1045e37c41
https://doi.org/10.1101/2020.12.03.403014
https://doi.org/10.1101/2020.12.03.403014