Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mihai I. Truica"'
Autor:
Sarki A. Abdulkadir, Huiying Han, Maha Hussain, Barbara Lysy, Jindan Yu, Vinay Sagar, Rajita Vatapalli, Young A. Yoo, Zachary R. Chalmers, Mihai I. Truica, Kenji Unno, Yara Rodríguez
Supplementary Table from A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c18cbe8dcd1d09b2c8163ac02fea55e
https://doi.org/10.1158/0008-5472.22430805.v1
https://doi.org/10.1158/0008-5472.22430805.v1
Autor:
Sarki A. Abdulkadir, Huiying Han, Maha Hussain, Barbara Lysy, Jindan Yu, Vinay Sagar, Rajita Vatapalli, Young A. Yoo, Zachary R. Chalmers, Mihai I. Truica, Kenji Unno, Yara Rodríguez
Supplementary Data from A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a65cf86c5c024da4f642116b5f59fe
https://doi.org/10.1158/0008-5472.22430820
https://doi.org/10.1158/0008-5472.22430820
Autor:
Sarki A. Abdulkadir, Huiying Han, Maha Hussain, Barbara Lysy, Jindan Yu, Vinay Sagar, Rajita Vatapalli, Young A. Yoo, Zachary R. Chalmers, Mihai I. Truica, Kenji Unno, Yara Rodríguez
Androgen receptor (AR) pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance to therapy is common. Here, we used a CRISPR activation screen in metastatic castration-sensitive prostate cancer cells to identify gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895b10adb5255602a915ab5a2543f5ab
https://doi.org/10.1158/0008-5472.c.6513723.v1
https://doi.org/10.1158/0008-5472.c.6513723.v1
Autor:
Yara Rodríguez, Kenji Unno, Mihai I. Truica, Zachary R. Chalmers, Young A. Yoo, Rajita Vatapalli, Vinay Sagar, Jindan Yu, Barbara Lysy, Maha Hussain, Huiying Han, Sarki A. Abdulkadir
Publikováno v:
Cancer Res
Androgen receptor (AR) pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance to therapy is common. Here, we used a CRISPR activation screen in metastatic castration-sensitive prostate cancer cells to identify gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe18c15a4a5a6b06d19b60ce0325d25
https://doi.org/10.1158/0008-5472.can-21-3565
https://doi.org/10.1158/0008-5472.can-21-3565
Autor:
Max M. Wang, Mihai I. Truica, Brayley Gattis, Xiaoyu Zhang, Sarki Abdulkadir, Nathan C. Gianneschi
Publikováno v:
Cancer Research. 83:2714-2714
Background: The proto-oncogene Myc is known to play critical roles in tumorigenesis, being dysregulated in >70% of human cancers. Development of small molecule Myc drugs has been hampered due to the lack of suitable binding pockets. Myc inhibitory pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd5601ad067aba0a234cd9ef0a8129e
https://doi.org/10.1158/1538-7445.am2023-2714
https://doi.org/10.1158/1538-7445.am2023-2714
Autor:
Austin G. Holmes, J. Brandon Parker, Vinay Sagar, Mihai I. Truica, Pritin N. Soni, Huiying Han, Gary E. Schiltz, Sarki A. Abdulkadir, Debabrata Chakravarti
Publikováno v:
Science advances. 8(17)
MYC regulates multiple gene programs, raising questions about the potential selectivity and downstream transcriptional consequences of MYC inhibitors as cancer therapeutics. Here, we examined the effect of a small-molecule MYC inhibitor, MYCi975, on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327ec8c8ad352ce2afd233e8dd6f453e
https://pubmed.ncbi.nlm.nih.gov/35476451
https://pubmed.ncbi.nlm.nih.gov/35476451
Autor:
Vinay Sagar, Barbara Lysy, Benedito A. Carneiro, Young Yoo, Mihai I. Truica, Huiying Han, Yara Rodriguez, Kenji Unno, Sarki A. Abdulkadir, Rajita Vatapalli, Zachary R. Chalmers, Jindan Yu, Jonathan F. Anker, Sahithi Pamarthy, Debabrata Chakravarti, Jie Zhao, Francis J. Giles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in prostate cancer (PCa) is undefined. Here we show that DOT1L is overexpressed in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9935bd7e2df8194043cb27a26ccd72e5
https://doaj.org/article/497ddec128fb4766b74876d35775416b
https://doaj.org/article/497ddec128fb4766b74876d35775416b
Autor:
Sarki A. Abdulkadir, Jasen M. Jackson, Roger S. Smith, Marc L. Mendillo, David R. Amici, Mihai I. Truica
Publikováno v:
Life Science Alliance
A tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.
Genetic coessen
Genetic coessen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e27c11550e55bee0662526054cc39e
https://pubmed.ncbi.nlm.nih.gov/33328249
https://pubmed.ncbi.nlm.nih.gov/33328249
Autor:
Huyin Han, Yara Rodriguez, Kenji Unno, Barbara Lysy, Sarki A. Abdulkadir, Vinay Sagar, Zachary R. Chalmers, Mihai I. Truica, Rajita Vatapalli, Young Yoo
Publikováno v:
Cancer Research. 80:4102-4102
Potent anti-androgens such as Enzalutamide (Enza) have been approved for the treatment of mCRPC. Despite initial response, nearly all patients eventually develop resistance to Enza. Although a few mechanisms of Enza resistance have been identified, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52ab1e99424b634d0462dca701d53db8
https://doi.org/10.1158/1538-7445.am2020-4102
https://doi.org/10.1158/1538-7445.am2020-4102
Autor:
Yi Luan, Young Yoo, Rama K. Mishra, Debabrata Chakravarti, Irawati Kandela, Gary E. Schiltz, Barbara Lysy, Huiying Han, Jonathan F. Anker, Zachary R. Chalmers, Sarki A. Abdulkadir, Javier Izquierdo-Ferrer, Rajita Vatapalli, Hanlin Mok, Atul D. Jain, Mihai I. Truica, Yara Rodriguez, Vinay Sagar, J. Brandon Parker, Kenji Unno
Publikováno v:
Cancer Cell
Summary Small molecules that directly target MYC and are also well tolerated in vivo will provide invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a series of small-molecule MYC inhibitors that engage MYC inside c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fe2da77985b3329c0db7f73072515d
https://doi.org/10.1016/j.ccell.2019.10.001
https://doi.org/10.1016/j.ccell.2019.10.001