Zobrazeno 1 - 10
of 1 560
pro vyhledávání: '"Mihai G, Netea"'
Autor:
Javier Botey-Bataller, Hedwig D. Vrijmoeth, Jeanine Ursinus, Bart-Jan Kullberg, Cees C. van den Wijngaard, Hadewych ter Hofstede, Ahmed Alaswad, Manoj K. Gupta, Lennart M. Roesner, Jochen Huehn, Thomas Werfel, Thomas F. Schulz, Cheng-Jian Xu, Mihai G. Netea, Joppe W. Hovius, Leo A. B. Joosten, Yang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before an
Externí odkaz:
https://doaj.org/article/e3dcc9f358504f8d8994380adb860b5e
Autor:
Maaike M.E. Jacobs, Rianne J.F. Maas, Inge Jonkman, Yutaka Negishi, Willem Tielemans Zamora, Cansu Yanginlar, Julia van Heck, Vasiliki Matzaraki, Joost H.A. Martens, Marijke Baltissen, Michiel Vermeulen, Judit Morla-Folch, Anna Ranzenigo, William Wang, Martin Umali, Jordi Ochando, Johan van der Vlag, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Mandy M.T. van Leent, Musa M. Mhlanga, Abraham J.P. Teunissen, Nils Rother, Raphaël Duivenvoorden
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114664- (2024)
Summary: Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the
Externí odkaz:
https://doaj.org/article/ad03aab3985e4aec8f638ad9ab1291e2
Autor:
Renee Salz, Emil E. Vorsteveld, Caspar I. van der Made, Simone Kersten, Merel Stemerdink, Tabea V. Riepe, Tsung-han Hsieh, Musa Mhlanga, Mihai G. Netea, Pieter-Jan Volders, Alexander Hoischen, Peter A.C. ’t Hoen
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110471- (2024)
Summary: We performed long-read transcriptome and proteome profiling of pathogen-stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors to discover new transcript and protein isoforms expressed during immune responses to diverse pa
Externí odkaz:
https://doaj.org/article/10beff8397b24bafb6bd4dd1d30ec867
Autor:
Hedwig D. Vrijmoeth, Jeanine Ursinus, Javier Botey-Bataller, Yunus Kuijpers, Xiaojing Chu, Freek R. van de Schoor, Brendon P. Scicluna, Cheng-Jian Xu, Mihai G. Netea, Bart Jan Kullberg, Cees C. van den Wijngaard, Yang Li, Joppe W. Hovius, Leo A. B. Joosten
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Genetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the course of signs and symptoms. Methods We performed genome-wide association studies in a pro
Externí odkaz:
https://doaj.org/article/023b3359336f429c8886cecd6f302253
Autor:
Collins K. Boahen, Hannah Abee, Isis Ricaño Ponce, Leo A. B. Joosten, Mihai G. Netea, Vinod Kumar
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Significant differences in immune responses, prevalence or susceptibility of diseases and treatment responses have been described between males and females. Despite this, sex-differentiation analysis of the genetic architecture of
Externí odkaz:
https://doaj.org/article/7271068d610c4509997707114808a248
Autor:
Asier Fernández-Pato, Trishla Sinha, Ranko Gacesa, Sergio Andreu-Sánchez, Milla F. Brandao Gois, Jody Gelderloos-Arends, Dianne B. H. Jansen, Marloes Kruk, Martin Jaeger, Leo A. B. Joosten, Mihai G. Netea, Rinse K. Weersma, Cisca Wijmenga, Hermie J. M. Harmsen, Jingyuan Fu, Alexandra Zhernakova, Alexander Kurilshikov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The lack of standardization in the methods of DNA extraction from fecal samples represents the major source of experimental variation in the microbiome research field. In this study, we aimed to compare the metagenomic profiles and microbiom
Externí odkaz:
https://doaj.org/article/52385fca2f7241a7beafe6bc3f4fd066
Autor:
Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J.A. Maas, Evelien G.G. Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A.B. Joosten, Bernhard Hube, Mihai G. Netea, Charles A. Dinarello, Mark S. Gresnigt
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTOur immune system possesses sophisticated mechanisms to cope with invading microorganisms, while pathogens evolve strategies to deal with threats imposed by host immunity. Human plasma protein α1-antitrypsin (AAT) exhibits pleiotropic immune
Externí odkaz:
https://doaj.org/article/69c249b8532c4a85b4278d546bfe2770
Autor:
Louise E. van Eekeren, Quirijn de Mast, Elise M.G. Meeder, Adriana Navas, Albert L. Groenendijk, Marc J.T. Blaauw, Wilhelm A.J.W. Vos, Nadira Vadaq, Jéssica C. Dos Santos, Joost Rutten, Niels P. Riksen, Jan van Lunzen, Gert Weijers, Mihai G. Netea, André J.A.M. van der Ven, Eric T.T.L. Tjwa, Leo A.B. Joosten
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105407- (2024)
Summary: Background: Insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease (MASLD) in people living with HIV (PLHIV) remain limited. Plasma proteomics holds promise for biomarker discovery and the elucidation o
Externí odkaz:
https://doaj.org/article/ef271a81f9d744ecb5a25b46cb60e8f7
Autor:
Julia van Tuijl, Julia I.P. van Heck, Harsh Bahrar, Wieteke Broeders, Johan Wijma, Yvonne M. ten Have, Martin Giera, Heidi Zweers-van Essen, Laura Rodwell, Leo A.B. Joosten, Mihai G. Netea, Lydia A. Afman, Siroon Bekkering, Niels P. Riksen
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111103- (2024)
Summary: Brief exposure of monocytes to atherogenic molecules, such as oxidized lipoproteins, triggers a persistent pro-inflammatory phenotype, named trained immunity. In mice, transient high-fat diet leads to trained immunity, which aggravates ather
Externí odkaz:
https://doaj.org/article/2cbb666c2b6342b7a4a95757c35a8009
Autor:
Xuehui He, Xinhui Wang, Julia van Heck, Bram van Cranenbroek, Esther van Rijssen, Rinke Stienstra, Mihai G. Netea, Irma Joosten, Cees J. Tack, Hans J. P. M. Koenen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Aims/hypothesisThere is increasing evidence for heterogeneity in type 1 diabetes mellitus (T1D): not only the age of onset and disease progression rate differ, but also the risk of complications varies markedly. Consequently, the presence of differen
Externí odkaz:
https://doaj.org/article/990e7c7ab51446099e6722a127616ced