Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mihai Ciustea"'
Autor:
Pier F. Cirillo, Thomas J. Powell, Michel Ledizet, Lin Leng, Oluwatoyin A. Asojo, Fengwei Bai, Mihai Ciustea, Raymond A. Koski, Karen Anthony, Richard Bucala, Paul A. Aristoff
Publikováno v:
Journal of Biological Chemistry. 287:30653-30663
Macrophage migration inhibitory factor (MIF) is a catalytic cytokine and an upstream mediator of the inflammatory pathway. MIF has broad regulatory properties, dysregulation of which has been implicated in the pathology of multiple immunological dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c84b97a25f8c03ab319235dfd4cb7e
https://doi.org/10.1074/jbc.m112.385583
https://doi.org/10.1074/jbc.m112.385583
Autor:
Michael H. Cynamon, Adriana E. Rosato, Michel Ledizet, Mihai Ciustea, Sara Mootien, Oriana A. Perez, Raymond A. Koski, Paul Kaplan, Karen Anthony, Pier F. Cirillo, Paul A. Aristoff, Kacheong R. Yeung
Publikováno v:
Biochemical Pharmacology. 83:368-377
Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen and a major cause of hospital-acquired infections. New antibacterial agents that have not been compromised by bacterial resistance are needed to treat MRSA-related infections. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b060dfd0cfc8f04ed852a3b974d0db
https://doi.org/10.1016/j.bcp.2011.11.021
https://doi.org/10.1016/j.bcp.2011.11.021
Publikováno v:
Journal of Medicinal Chemistry. 51:6563-6570
Variola virus, the causative agent of smallpox, is a potential bioweapon. The development of new antiviral compounds for smallpox prophylaxis and treatment is critical, especially because the virus can acquire resistance to the drugs that are current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2730841e067b0547ec2e0c849a767bc5
https://doi.org/10.1021/jm800366g
https://doi.org/10.1021/jm800366g
Publikováno v:
Organic Letters. 5:2033-2036
[structure: see text] The synthesis of N-acylsulfonamide 6, which is an analogue of beta-aspartyl-AMP, is described. This compound appears to be the first and only potent inhibitor of human asparagine synthetase that has been described to date. The N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181513fff9bac875f4c93456bcdca0ef
https://doi.org/10.1021/ol034212n
https://doi.org/10.1021/ol034212n
Autor:
Janice Elaine Y. Silverman, James M. Hogle, Donald M. Coen, Mihai Ciustea, David J. Filman, Jennifer L. Baltz, Robert P. Ricciardi, Catherine Lautenschlager
Publikováno v:
Journal of virology. 83(23)
Kaposi's sarcoma-associated herpesvirus is an emerging pathogen whose mechanism of replication is poorly understood. PF-8, the presumed processivity factor of Kaposi's sarcoma-associated herpesvirus DNA polymerase, acts in combination with the cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbf796e59d562b42c9d9845bbe61174
https://pubmed.ncbi.nlm.nih.gov/19759157
https://pubmed.ncbi.nlm.nih.gov/19759157
Autor:
Abigail M. Druck Shudofsky, Florent C. Bender, Janice Elaine Y. Silverman, Mihai Ciustea, Robert H. Shoemaker, Robert P. Ricciardi
Publikováno v:
Antiviral research. 80(2)
Nearly all DNA polymerases require processivity factors to ensure continuous incorporation of nucleotides. Processivity factors are specific for their cognate DNA polymerases. For this reason, the vaccinia DNA polymerase (E9) and the proteins associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca048f3cd507517620a34c2dbcc24ebc
https://pubmed.ncbi.nlm.nih.gov/18621425
https://pubmed.ncbi.nlm.nih.gov/18621425
Publikováno v:
Virology. 340(2)
Kaposi's sarcoma-associated human herpesvirus (KSHV) encodes a processivity factor (PF-8, ORF59) that forms homodimers and binds to viral DNA polymerase (Pol-8, ORF9). PF-8 is essential for stabilizing Pol-8 on template DNA so that Pol-8 can incorpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f82af4d2dcb465c59befa88370df7c
https://pubmed.ncbi.nlm.nih.gov/16043206
https://pubmed.ncbi.nlm.nih.gov/16043206
Publikováno v:
Archives of biochemistry and biophysics. 413(1)
Escherichia coli asparagine synthetase B (AS-B) catalyzes the formation of asparagine from aspartate in an ATP-dependent reaction for which glutamine is the in vivo nitrogen source. In an effort to reconcile several different kinetic models that have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126564bf7d75f295416fe75d8cd90c0b
https://pubmed.ncbi.nlm.nih.gov/12706338
https://pubmed.ncbi.nlm.nih.gov/12706338
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 20, p6563-6570, 8p