Febuxostat–p-Toluenesulfonic Acid Multi-Component Crystal: Characterization, Crystal Growth and Elucidation of the Salt/Co-Crystal Nature

Autor: Doriana T. Ungur, Gustavo Santiso-Quinones, Mihaela M. Pop, Tudor L. Tamas, Carmen Guguta, Danny Stam, Alice Mija, Coca A. Iordache

Publikováno v: Crystals, Vol 13, Iss 5, p 836 (2023)

The multi-component solid form of febuxostat (FEB) with p-toluenesulfonic acid was synthesized by solvent-drop grinding and cooling-evaporative crystallization and characterized by powder X-ray diffraction (XRPD), thermogravimetry (TGA), differential

Externí odkaz: https://doaj.org/article/e234c0ea69394a1a858abb476f93d09e

Simultaneous data assimilation and cardiac electrophysiology model correction using differentiable physics and deep learning.

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Autor: Eötvös CA; 'Niculae Stancioiu' Heart Institute, 400001 Cluj-Napoca, Romania.; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania., Lazar RD; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania., Zehan IG; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania., Lévay-Hail EB; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania., Pastiu G; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania., Pop M; Schulich Heart Research Program, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Bojan AS; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Ion Chiricuta Oncology Institute, 400015 Cluj-Napoca, Romania., Pop S; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania., Blendea D; Department of Medicine, Faculty of Medicine, University of Medicine and Pharmacy 'Iuliu Hatieganu', 400012 Cluj-Napoca, Romania.; Cluj County Emergency Hospital, 400000 Cluj-Napoca, Romania.

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Autor: Triandafillidis DP; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Parthenios N; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Spiliopoulou M; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Valmas A; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Kosinas C; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Gozzo F; Excelsus Structural Solutions (Swiss) AG, Park Innovaare, 5234 Villigen, Switzerland., Reinle-Schmitt M; Excelsus Structural Solutions (Swiss) AG, Park Innovaare, 5234 Villigen, Switzerland., Beckers D; Malvern Panalytical B.V., Lelyweg 1, Almelo, NL-7602, The Netherlands., Degen T; Malvern Panalytical B.V., Lelyweg 1, Almelo, NL-7602, The Netherlands., Pop M; TeraCrystal SRL, Donat 67-103, B2.04, Cluj-Napoca, 400293 Cluj, Romania., Fitch AN; European Synchrotron Radiation Facility, BP-220, F-38043 Grenoble CEDEX 9, France., Wollenhaupt J; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, D-35032 Marburg, Germany., Weiss MS; Department of Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, D-12489 Berlin, Germany., Karavassili F; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece., Margiolaki I; Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, GR-26500 Patras, Greece.

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