Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Mihaela M. Mocanu"'
Autor:
Ross A. Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J. Ragan, James A. West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C. Kienesberger, Ryszard T. Smolenski, Hillary K. Siddall, John L. Offer, Mihaela M. Mocanu, Derek M. Yelon, Jason R. B. Dyck, Jules L. Griffin, Andrey Y. Abramov, Alex P. Gould, Timothy J. Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/6a8fd36805ff492ba96d5efe8f050325
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Autor:
Hilary K Siddall, Derek M Yellon, Sang-Bing Ong, Uma A Mukherjee, Niall Burke, Andrew R Hall, Plamena R Angelova, Marthe H R Ludtmann, Emma Deas, Sean M Davidson, Mihaela M Mocanu, Derek J Hausenloy
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62400 (2013)
Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that
Externí odkaz:
https://doaj.org/article/dde8266e1e2f4f309d4fe3816f92898f
Autor:
Hilary K. Siddall, Derek M. Yellon, Sang-Bing Ong, Uma A. Mukherjee, Niall Burke, Andrew R. Hall, Plamena R. Angelova, Marthe H. R. Ludtmann, Emma Deas, Sean M. Davidson, Mihaela M. Mocanu, Derek J. Hausenloy
Publikováno v:
PLoS ONE, Vol 8, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/c75a8916fe1b4752b8347e6dbf0e222e
Autor:
Hannah J. Whittington, Girish G. Babu, Mihaela M. Mocanu, Derek M. Yellon, Derek J. Hausenloy
Publikováno v:
Cardiology Research and Practice, Vol 2012 (2012)
Diabetes mellitus is a major risk factor for ischemic heart disease (IHD). Patients with diabetes and IHD experience worse clinical outcomes, suggesting that the diabetic heart may be more susceptible to ischemia-reperfusion injury (IRI). In contrast
Externí odkaz:
https://doaj.org/article/aa7568e1d65547ffb9eac51a45e9f84d
Autor:
Mihaela M. Mocanu, Clemency Stephenson, Hannah J. Whittington, Derek M. Yellon, Derek J. Hausenloy, Robert G. Bell, Idris Harding
Publikováno v:
Cardiovascular Research. 99:694-704
Aims Old age and diabetes are risk factors that often coexist increasing the vulnerability of the heart to the lethal effects of ischaemia–reperfusion injury (IRI). However, to our knowledge, no investigations have examined IRI and cardioprotective
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 18:263-269
Aims: The diabetic heart is resistant to the myocardial infarct-limiting effects of ischemic preconditioning (IPC). This may be in part due to the downregulation of the phosphatidylinositol 3′-kinase-Akt pathway, an essential component of IPC prote
Autor:
Hannah J. Whittington, Derek M. Yellon, Andrew R. Hall, Derek J. Hausenloy, Catarina P. McLaughlin, Mihaela M. Mocanu
Publikováno v:
Cardiovascular Drugs and Therapy. 27:5-16
Clinical and experimental investigations demonstrated that metformin, a widely used anti-diabetic drug, exhibits cardioprotective properties against myocardial infarction. Interestingly, metformin was previously shown to increase the expression of PG
Publikováno v:
Journal of Molecular and Cellular Cardiology. 50:940-950
In the late 19th century, a number of investigators were working on perfecting isolated heart model, but it was Oscar Langendorff who, in 1895, pioneered the isolated perfused mammalian heart. Since that time, the Langendorff preparation has evolved
Autor:
Bruce E. Keogh, Derek M. Yellon, Shyam Kolvekar, Mihaela M. Mocanu, Naveen R. Mudalagiri, Martin Hayward, C Di Salvo, John Yap
Publikováno v:
British Journal of Pharmacology. 153:50-56
Background and purposes: Erythropoietin (EPO) has been shown to protect against myocardial infarction in animal studies by activating phosphatidylinositol-3 kinase (PI3K)/Akt and ERK1/2. However these pro-survival pathways are impaired in the diabeti