Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mihaela Lorger"'
Autor:
Chiara Galloni, Teklu Egnuni, Safoura Zahed Mohajerani, Jiaqi Ye, Sibylle Mittnacht, Valerie Speirs, Mihaela Lorger, Georgia Mavria
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The role of endothelial cells in promoting cancer cell extravasation to the brain during the interaction of cancer cells with the vasculature is not well characterised. We show that brain endothelial cells activate EGFR signalling in triple-
Externí odkaz:
https://doaj.org/article/cd26aee6a2a548fb9ca20940a8ec9c7a
Autor:
Ashley Sunderland, Jennifer Williams, Tereza Andreou, Nora Rippaus, Christopher Fife, Fiona James, Yolanda Dyah Kartika, Valerie Speirs, Ian Carr, Alastair Droop, Mihaela Lorger
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an in vivo model of triple negative brea
Externí odkaz:
https://doaj.org/article/edd0e15041a74a878fd5719f0821bcfc
Autor:
Helen Carrasco Hope, Rebecca J. Brownlie, Christopher M. Fife, Lynette Steele, Mihaela Lorger, Robert J. Salmond
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surf
Externí odkaz:
https://doaj.org/article/f09dbfc3ff2c45ebbd590954c6ced5e4
Autor:
Jennifer Williams, Gary Shaw, Tereza Andreou, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Heiko Wurdak, Susan C Short, Mihaela Lorger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratu
Externí odkaz:
https://doaj.org/article/326e3a4093304c04a49a76c0b552d643
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and immune check
Externí odkaz:
https://doaj.org/article/011e7833f36e4efb9fbab3a7c1a8c0f1
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Autor:
Mihaela Lorger
Publikováno v:
Cancers, Vol 4, Iss 1, Pp 218-243 (2012)
In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inh
Externí odkaz:
https://doaj.org/article/c9b40d510f7e419f927773822a51837a
Autor:
Moritz W. J. Schramm, Stuart Currie, Ming-te Lee, Laurent J. Livermore, Sandeep P. Solanki, Ryan K. Mathew, Heiko Wurdak, Mihaela Lorger, Chris Twelves, Susan C. Short, Aruna Chakrabarty, Paul Chumas
Publikováno v:
Journal of Neuro-Oncology. 161:451-467
Introduction Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, there is growi
Autor:
Frank Winkler, Frances Weis-Garcia, Adina Vultur, Damir Varešlija, Leonie S. Young, Frits Thorsen, Patricia S. Steeg, Nicola R. Sibson, Josh Neman, Joan Massague, Mihaela Lorger, Johanna A. Joyce, Rakesh K. Jain, Sheri L. Holmen, Meenhard Herlyn, Brunilde Gril, Dai Fukumura, Gino B. Ferraro, Neta Erez, Diana M. Cittelly, Paula D. Bos, Adrienne Boire, Amos Bairoch, Carey K. Anders, Amanda E.D. Van Swearingen, Manuel Valiente
Table containing all brain metastatic cell lines in the BrMPanel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96de9510aa2f0aeec245f5f8a56eb785
https://doi.org/10.1158/0008-5472.22425940
https://doi.org/10.1158/0008-5472.22425940
Autor:
Frank Winkler, Frances Weis-Garcia, Adina Vultur, Damir Varešlija, Leonie S. Young, Frits Thorsen, Patricia S. Steeg, Nicola R. Sibson, Josh Neman, Joan Massague, Mihaela Lorger, Johanna A. Joyce, Rakesh K. Jain, Sheri L. Holmen, Meenhard Herlyn, Brunilde Gril, Dai Fukumura, Gino B. Ferraro, Neta Erez, Diana M. Cittelly, Paula D. Bos, Adrienne Boire, Amos Bairoch, Carey K. Anders, Amanda E.D. Van Swearingen, Manuel Valiente
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect in the pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42c81539e428456b11ca0d14895476
https://doi.org/10.1158/0008-5472.c.6512188
https://doi.org/10.1158/0008-5472.c.6512188