Výsledky vyhledávání - "Mihaela Culmes"

Akademický článek

5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation.

Autor: Xueying Yan, Sabrina Ehnert, Mihaela Culmes, Anastasia Bachmann, Claudine Seeliger, Lilianna Schyschka, Zhiyong Wang, Afshin Rahmanian-Schwarz, Ulrich Stöckle, Paul A De Sousa, Jaroslav Pelisek, Andreas K Nussler

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e90846 (2014)

The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro cult

Externí odkaz: https://doaj.org/article/8f86b6f89d2046239137840d288eb211

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Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

Autor: Harry Gebhard, Jaroslav Pelisek, Alma Zernecke, Alexander Zimmermann, Ernst Wagner, Hans-Henning Eckstein, Anna Greißel, Mihaela Culmes, Manfred Schmitt, Rudolf Napieralski

Publikováno v: Thrombosis and Haemostasis. 114:390-402

SummaryLittle is known about epigenetics and its possible role in atherosclerosis. We here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5ac9bed6a74013a1c9a763735e08cf
https://doi.org/10.1160/th14-10-0852

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Die epigenetische Substanz BIX-01294 verbessert die Differenzierung mesenchymaler Zellen aus humanem Fettgewebe in Endothelzellen

Autor: Mihaela Culmes, Jaroslav Pelisek, Alma Zernecke, Hans-Henning Eckstein

Publikováno v: Gefässchirurgie. 19:69-76

Patienteneigene Endothellzellen zur Auskleidung von Gefasprothesen wurden die Uberlebenschance der betroffenen Patienten deutlich erhohen und die Komplikationsrate signifikant reduzieren. Entsprechende Zellen sind jedoch schwierig in ausreichender Za

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e965affe49b53b591a1d1a5c270f4c9
https://doi.org/10.1007/s00772-013-1271-0

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Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294

Autor: Michael Guenther, Hans-Henning Eckstein, Andreas K. Nussler, Jaroslav Pelisek, Mihaela Culmes, Rainer Burgkart, Ernst Wagner

Publikováno v: European Journal of Cell Biology. 92:70-79

Chromatin remodeling plays an essential role in regulation of gene transcription. Consequently, targeted changes in chromatin may also augment pluripotency of somatic cells. The aim of the present study was to evaluate the effect of epigenetic drug B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62888fd1a6bf9ea6f719bf14310d581
https://doi.org/10.1016/j.ejcb.2012.11.001

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Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

Autor: Anna Greißel, Rainer Burgkart, Alexander Zimmermann, Alma Zernecke, Hans-Henning Eckstein, Mihaela Culmes, Jaroslav Pelisek

Publikováno v: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 25(2)

The aim of the study was to analyze histone acetylation, methylation, and the expression of their corresponding transferases in atherosclerotic plaques of patients with carotid artery stenosis.Atherosclerotic tissue from our biobank (n=80) was divide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cf57122d0a3ba9285fccd0fc5a6432
https://pubmed.ncbi.nlm.nih.gov/26764138

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5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation

Autor: Zhiyong Wang, Mihaela Culmes, Claudine Seeliger, Andreas K. Nussler, Jaroslav Pelisek, Sabrina Ehnert, Paul A. De Sousa, Afshin Rahmanian-Schwarz, Lilianna Schyschka, Anastasia Bachmann, Ulrich Stöckle, X. Yan

Publikováno v: Yan, X, Ehnert, S, Culmes, M, Bachmann, A, Seeliger, C, Schyschka, L, Wang, Z, Rahmanian-Schwarz, A, Stöckle, U, De Sousa, P A, Pelisek, J & Nussler, A K 2014, ' 5-azacytidine improves the osteogenic differentiation potential of aged human adipose-derived mesenchymal stem cells by DNA demethylation ', PLoS ONE, vol. 9, no. 3, pp. e90846 . https://doi.org/10.1371/journal.pone.0090846
PLoS ONE, Vol 9, Iss 6, p e90846 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9968d2723a3b7c82f451ef58468d1070
https://hdl.handle.net/20.500.11820/e9f5c223-ca43-4148-918f-649eda900e51

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Decellularized kidney matrix for perfused bone engineering

Autor: Rainer Burgkart, Andreas Schmitt, Martijn van Griensven, Mihaela Culmes, Jutta Tuebel, Belma Saldamli, Alexandru Tron, Peter Michael Prodinger

Publikováno v: Tissue Engineering. Part C. Methods, 20(7), 553-61. Mary Ann Liebert Inc.

The vascularization of tissue-engineered constructs is yet an unsolved problem. Here, recent work on the decellularization of whole organs has opened new perspectives on tissue engineering. However, existing decellularization protocols last several d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57319bde10f0733a57edeaf39f4c792b
https://pubmed.ncbi.nlm.nih.gov/24164381

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Decrease of global methylation improves significantly hepatic differentiation of Ad-MSCs: possible future application for urea detoxification

Autor: Jörg Kleeff, Ulrich Stöckle, Sabrina Ehnert, Zhong-Jing Wang, Wolfgang E. Thasler, Mihaela Culmes, Claudine Seeliger, Andreas K. Nussler, Lilianna Schyschka, Jan G. Hengstler, Georg Damm, X Yan

Publikováno v: Cell Transplantation, Vol 22 (2013)
Cell Transplantation; Vol 22
Cell Transplantation

Hepatocyte transplantation is considered to be an alternative to orthotopic liver transplantation. Cells can be used to bridge patients waiting for a donor organ, decrease mortality in acute liver failure, and support metabolic liver diseases. The li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1914309be758a0d6922d966b0a72b3a2
https://pubmed.ncbi.nlm.nih.gov/22507189

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Neovascularization and angiogenic factors in advanced human carotid artery stenosis

Autor: Andreas Kuehnl, Alexander Zimmermann, Jaroslav Pelisek, Hans-Henning Eckstein, Holger Poppert, Martina Rudelius, Christian Reeps, Georg Well, Hermann Berger, Mihaela Culmes

Publikováno v: Circulation journal : official journal of the Japanese Circulation Society. 76(5)

Background: Most atherosclerotic lesions are vascularized, so neovessels may also contribute to plaque progression and vulnerability, but their precise role of neovessels in atherosclerosis is still unknown. The aim of this study was to analyze the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc20e26c127e43c7560d91f87829e3e
https://pubmed.ncbi.nlm.nih.gov/22447000

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