Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Mihael H Polymeropoulos"'
Autor:
Mark É Czeisler, Justina M Pruski, Pan Wang, Jingyuan Wang, Changfu Xiao, Mihael H Polymeropoulos, Vasilios M Polymeropoulos
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280058 (2023)
BackgroundMotion sickness is characterized by nausea and vomiting among a constellation of symptoms. Symptom severity is dynamic and distressing. Most validated motion sickness scales are time-intensive and effortful, with alternative scales having u
Externí odkaz:
https://doaj.org/article/057d00d7b3d240808b5c60c04d00cab1
Autor:
Fusun Doldur-Balli, Sandra P. Smieszek, Brendan T. Keenan, Amber J. Zimmerman, Olivia J. Veatch, Christos M. Polymeropoulos, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate electrical rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel blocker compound, Ivabradine (Corlanor), is approved by the US Food
Externí odkaz:
https://doaj.org/article/9bfd696bb33c4d3095ac941c65f80b99
Autor:
Sandra P. Smieszek, Alyssa R. Kaden, Caroline E. Johnson, Jennifer L. Brzezynski, Changfu Xiao, Christos M. Polymeropoulos, Gunther Birznieks, Helene A. Emsellem, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/14a11e46f1354a62a34f537c691cff0c
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Melanopsin (OPN4) is a blue light-sensitive opsin-type G-protein coupled receptor. It is highly expressed in photosensitive retinal ganglion cells which mediate responses to light, including regulation of sleep, circadian photoentrainment, and pupill
Externí odkaz:
https://doaj.org/article/bedbf1179fb24c5cb0f1bba1d14d93c5
Autor:
Christos M. Polymeropoulos, Vasilios M. Polymeropoulos, Emily L. Czeisler, Michaela A. Fisher, Sandra P. Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Jet Lag Disorder is a Circadian Rhythm Sleep-Wake Disorder resulting from a misalignment of the endogenous circadian clock and the sleep and wake pattern required by a change in time zone. Jet lag is most severe following eastward travel. This multic
Externí odkaz:
https://doaj.org/article/9141a5eee9d9441380b4388b1fb12e52
Autor:
Vasilios M. Polymeropoulos, Mark É. Czeisler, Mary M. Gibson, Austin A. Anderson, Jane Miglo, Jingyuan Wang, Changfu Xiao, Christos M. Polymeropoulos, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Introduction: Novel therapies are needed for the treatment of motion sickness given the inadequate relief and bothersome and dangerous adverse effects of currently approved therapies. Neurokinin-1 (NK1) receptor antagonists have the potential to be e
Externí odkaz:
https://doaj.org/article/b0ec418e283643938f672267284d7ff0
Autor:
Christos M. Polymeropoulos, Michael A. Mohrman, Madison S. Keefe, Jennifer L. Brzezynski, Jingyuan Wang, Lydia S. Prokosch, Vasilios M. Polymeropoulos, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Most travelers experience Jet Lag Disorder (JLD) symptoms due to misalignment of their circadian rhythms with respect to the new time zone. We assessed the efficacy and safety of tasimelteon (HETLIOZ®) in healthy participants using a lab
Externí odkaz:
https://doaj.org/article/4205f34038144886b4800b987370a676
Autor:
Prabhakaran Kumar, Manikannan Mathayan, Sandra P. Smieszek, Bartlomiej P. Przychodzen, Vuk Koprivica, Gunther Birznieks, Mihael H. Polymeropoulos, Bellur S. Prabhakar
Publikováno v:
Virology. 572:64-71
Recurrent waves of COVID19 remain a major global health concern. Repurposing either FDA-approved or clinically advanced drug candidates can save time and effort required for validating the safety profile and FDA approval. However, the selection of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69fb35c22c41f00935187e784594c9e
https://doi.org/10.1016/j.virol.2022.05.004
https://doi.org/10.1016/j.virol.2022.05.004
Autor:
Kailey Kite, Sarah H. Elsea, Emily Czeisler, Justin Brooks, Gunther Birznieks, Mary M. Gibson, Christos Polymeropoulos, Michaela Fisher, Mihael H. Polymeropoulos, Sandra P. Smieszek, Changfu Xiao
Publikováno v:
Genetics in Medicine
Purpose To assess the efficacy of tasimelteon to improve sleep in Smith–Magenis syndrome (SMS). Methods A 9-week, double-blind, randomized, two-period crossover study was conducted at four US clinical centers. Genetically confirmed patients with SM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e8876c209d6f678e7485b19e62484
https://doi.org/10.1038/s41436-021-01282-y
https://doi.org/10.1038/s41436-021-01282-y
Autor:
Michael A Mohrman, Christos Polymeropoulos, Sarah E Welsh, Mihael H. Polymeropoulos, Jingyuan Wang, Sonja Ständer, Bartlomiej P Przychodzen, Sandra P. Smieszek, Changfu Xiao, Alyssa R. Kaden, Jennifer L. Brzezynski, Gunther Birznieks
Publikováno v:
Journal of the American Academy of Dermatology. 85:1638-1640
ABTRACT Background Atopic dermatitis (AD) is a heritable and heterogeneous inflammatory chronic skin disorder. Utilizing decision tree/supervised learning of extensive clinical, molecular and genetic data, we aimed to define distinct AD endotypes. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2816285ad22601aeff09ed66cbe6372e
https://doi.org/10.1016/j.jaad.2020.11.072
https://doi.org/10.1016/j.jaad.2020.11.072