Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Mihael H Polymeropoulos"'
Autor:
Fusun Doldur-Balli, Sandra P. Smieszek, Brendan T. Keenan, Amber J. Zimmerman, Olivia J. Veatch, Christos M. Polymeropoulos, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate electrical rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel blocker compound, Ivabradine (Corlanor), is approved by the US Food
Externí odkaz:
https://doaj.org/article/9bfd696bb33c4d3095ac941c65f80b99
Autor:
Sandra P. Smieszek, Alyssa R. Kaden, Caroline E. Johnson, Jennifer L. Brzezynski, Changfu Xiao, Christos M. Polymeropoulos, Gunther Birznieks, Helene A. Emsellem, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/14a11e46f1354a62a34f537c691cff0c
Autor:
Sandra P. Smieszek, Alyssa R. Kaden, Caroline E. Johnson, Jennifer L. Brzezynski, Changfu Xiao, Christos M. Polymeropoulos, Gunther Birznieks, Helene A. Emsellem, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedti
Externí odkaz:
https://doaj.org/article/f589729aa856428993781c052938b15b
Publikováno v:
Journal of Human, Earth, and Future, Vol 3, Iss 0, Pp 22-29 (2022)
Animals are used as preclinical models for human diseases in drug development. Dogs, especially, are used in preclinical research to support clinical safety evaluations during drug development. Comparisons of patterns of regions of homozygosity (ROH)
Externí odkaz:
https://doaj.org/article/c7dd084eb6c84eb498a47f1f15b90db1
Autor:
Mark É Czeisler, Justina M Pruski, Pan Wang, Jingyuan Wang, Changfu Xiao, Mihael H Polymeropoulos, Vasilios M Polymeropoulos
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280058 (2023)
BackgroundMotion sickness is characterized by nausea and vomiting among a constellation of symptoms. Symptom severity is dynamic and distressing. Most validated motion sickness scales are time-intensive and effortful, with alternative scales having u
Externí odkaz:
https://doaj.org/article/057d00d7b3d240808b5c60c04d00cab1
Autor:
Sandra P. Smieszek, Jennifer L. Brzezynski, Alyssa R. Kaden, Jordan A. Shinn, Jingyuan Wang, Changfu Xiao, Christos Polymeropoulos, Tayfun Özçelik, Mihael H. Polymeropoulos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
Abstract We conducted an observational research study to collect information on sleep–wake patterns from participants with a confirmed status of the cryptochrome circadian clock 1 (CRY1) splicing variant, CRY1Δ11 c.1657 + 3A > C, and their control
Externí odkaz:
https://doaj.org/article/4e5bf9db79254b2b84727898be0d5a4f
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Melanopsin (OPN4) is a blue light-sensitive opsin-type G-protein coupled receptor. It is highly expressed in photosensitive retinal ganglion cells which mediate responses to light, including regulation of sleep, circadian photoentrainment, and pupill
Externí odkaz:
https://doaj.org/article/bedbf1179fb24c5cb0f1bba1d14d93c5
Autor:
Christos M. Polymeropoulos, Vasilios M. Polymeropoulos, Emily L. Czeisler, Michaela A. Fisher, Sandra P. Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Jet Lag Disorder is a Circadian Rhythm Sleep-Wake Disorder resulting from a misalignment of the endogenous circadian clock and the sleep and wake pattern required by a change in time zone. Jet lag is most severe following eastward travel. This multic
Externí odkaz:
https://doaj.org/article/9141a5eee9d9441380b4388b1fb12e52
Autor:
Sandra P. Smieszek, Vasilios M. Polymeropoulos, Changfu Xiao, Christos M. Polymeropoulos, Mihael H. Polymeropoulos
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 26, Iss , Pp 239-240 (2021)
ABSTRACT: Recent COVID-19 (coronavirus disease 2019) host genetics studies suggest enrichment of mutations in genes involved in the regulation of type I and type III interferon (IFN) immunity in patients with severe COVID-19 infection. We performed w
Externí odkaz:
https://doaj.org/article/110288d840784683ad38a2a834a82611
Publikováno v:
Frontiers in Neurology, Vol 11 (2021)
Purpose: To quantify the burden of disease in blind patients with Non-24-H Sleep- Wake Disorder (N24HSWD), utilizing longitudinal sleep diary data. N24HSWD is a circadian disorder characterized by a cyclical pattern of aberrant circadian and sleep-wa
Externí odkaz:
https://doaj.org/article/8d866c3861564611a76b266403cce8ae