Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Miha Mraz"'
Autor:
Eva Kočar, Sonja Katz, Žiga Pušnik, Cene Skubic, Tadeja Režen, Vitor A.P. Martins dos Santos, Miha Mraz, Miha Moškon, Damjana Rozman
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103213- (2024)
Summary: The growing interest in clinical diagnostics has recently focused on metabolic biomarkers. Here, we present a protocol for sample preparation, extraction of cholesterol-related sterols, and quantification of 10 sterols in human blood serum s
Externí odkaz:
https://doaj.org/article/2f867cb2b9084d98950ab77d2ac0f316
Autor:
Eva Kočar, Sonja Katz, Žiga Pušnik, Petra Bogovič, Gabriele Turel, Cene Skubic, Tadeja Režen, Franc Strle, Vitor A.P. Martins dos Santos, Miha Mraz, Miha Moškon, Damjana Rozman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107799- (2023)
Summary: With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol biosynthesis by comparing 10 intermediate
Externí odkaz:
https://doaj.org/article/3958b7b48d78468b921574809fc47d07
Publikováno v:
Heliyon, Vol 8, Iss 8, Pp e10222- (2022)
Boolean descriptions of gene regulatory networks can provide an insight into interactions between genes. Boolean networks hold predictive power, are easy to understand, and can be used to simulate the observed networks in different scenarios.We revie
Externí odkaz:
https://doaj.org/article/2fb956673d7f4640b441cf37841f7bac
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3521-3530 (2021)
Omics data can be integrated into a reference model using various model extraction methods (MEMs) to yield context-specific genome-scale metabolic models (GEMs). How to chose the appropriate MEM, thresholding rule and threshold remains a challenge. W
Externí odkaz:
https://doaj.org/article/db4c20c2164a46089ee4723bddbac05a
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-21 (2019)
Abstract Background Gene regulatory networks with different topological and/or dynamical properties might exhibit similar behavior. System that is less perceptive for the perturbations of its internal and external factors should be preferred. Methods
Externí odkaz:
https://doaj.org/article/0e3903343de046dfa3e476549bebb3c2
Initial state perturbations as a validation method for data-driven fuzzy models of cellular networks
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Data-driven methods that automatically learn relations between attributes from given data are a popular tool for building mathematical models in computational biology. Since measurements are prone to errors, approaches dealing wit
Externí odkaz:
https://doaj.org/article/140fffee6246401eacf42995c7c9f013
Publikováno v:
Acta Chimica Slovenica, Vol 65, Iss 2, Pp 253-265 (2018)
Computational models of liver metabolism are gaining an increasing importance within the research community. Moreover, their first clinical applications have been reported in recent years in the context of personalised and systems medicine. Herein, w
Externí odkaz:
https://doaj.org/article/d8c0ee613f7a4a87bc949bb87f7c154a
Autor:
Miha Moškon, Miha Mraz
Publikováno v:
Neural Computing and Applications. 34:19239-19251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e9e01ac347590afb68027ca69c727f
https://doi.org/10.1007/s00521-022-07532-7
https://doi.org/10.1007/s00521-022-07532-7
Autor:
Kaja Blagotinšek Cokan, Žiga Urlep, Miha Moškon, Miha Mraz, Xiang Yi Kong, Winnie Eskild, Damjana Rozman, Peter Juvan, Tadeja Režen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 832 (2021)
Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signature
Externí odkaz:
https://doaj.org/article/9ff6cf5bb655424ca1f5e758f321d63f
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The liver is to date the best example of a sexually dimorphic non-reproductive organ. Over 1,000 genes are differentially expressed between sexes indicating that female and male livers are two metabolically distinct organs. The spectrum of liver dise
Externí odkaz:
https://doaj.org/article/5b120d8f2e884bfc8c4c931f5813a3c6