Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Miha Homar"'
Autor:
Uroš Urleb, Marija Petrusevska, Miha Homar, Darko Kocjan, Luka Peternel, Boštjan Petek, Aleksander Resman
Publikováno v:
Molecular Pharmaceutics. 10:2299-2310
The aim of this study was to develop a sirolimus (BCS class II drug substance) solid oral dosage form containing a precipitation inhibitor, which would result in an improved sirolimus absorption in humans compared to the formulation containing nanosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a81e0daf7a86998797f2231ce8f5dff
https://doi.org/10.1021/mp300641h
https://doi.org/10.1021/mp300641h
Publikováno v:
Drug and Chemical Toxicology. 36:263-269
The toxicity of amiodarone Lek formulation (test formulation) was investigated after a single intravenous (i.v.) administration to mice and rats. When compared to the reference item, Cordarone (Cordarone(®); Wyeth Pharmaceuticals Inc., Collegeville,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a72913836adf14c9d2cef0373ca7523
https://doi.org/10.3109/01480545.2012.710628
https://doi.org/10.3109/01480545.2012.710628
Publikováno v:
International Journal of Pharmaceutics. 381:176-183
Drug-free microparticles were prepared using a spray congealing process with the intention of studying the influence of processing parameters. By varying the atomizing pressure and liquid feed rate, microparticles with median sizes ( d (0.5) ) from 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e15e4d8a6e01ca4e674158ee3680127
https://doi.org/10.1016/j.ijpharm.2009.05.011
https://doi.org/10.1016/j.ijpharm.2009.05.011
Publikováno v:
Journal of Microencapsulation. 26:479-484
The purpose of this study was to prepare alginate microcapsules with a self-microemulsifying system (SMES) containing celecoxib in the core. An Inotech IE-50 R encapsulator equipped with a concentric nozzle was used to prepare the microcapsules. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32be659a912a6ee4d17cdf3c82ecc9e
https://doi.org/10.1080/02652040802383839
https://doi.org/10.1080/02652040802383839
Publikováno v:
Acta chimica Slovenica. 58(2)
The aim of the study was to evaluate a hot-melt technique for preparation of immediate release spherical microparticles containing clarithromycin with acceptable characteristics and process yield. A modified fluid bed apparatus with rotor insert was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd935185964340ecdcafe08425dc139c
https://pubmed.ncbi.nlm.nih.gov/24062042
https://pubmed.ncbi.nlm.nih.gov/24062042
Publikováno v:
Pharmaceutical development and technology. 18(2)
The feasibility of incorporating a solid dispersion containing poorly soluble antidiabetic drug glimepiride and poly(ester amide) hyperbranched polymer into a tablet using a direct-compression tabletting technique was investigated. Tablet cores were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a687afc5ccaefe228b0b4e3b453a76
https://pubmed.ncbi.nlm.nih.gov/21812524
https://pubmed.ncbi.nlm.nih.gov/21812524
Publikováno v:
Seminars in thrombosis and hemostasis. 36(1)
Despite intensive research in the field of oral anticoagulants over the last decade, simple and effective long-term prevention of thromboembolism is still an unmet need. In addition to drug discovery approaches, the development of novel oral drug del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef0d0f45f983652ece6684358fec2ad
https://pubmed.ncbi.nlm.nih.gov/20391302
https://pubmed.ncbi.nlm.nih.gov/20391302
Autor:
Janez Kerc, Philippe Maincent, Fatima El Ghazouani, Julijana Kristl, Miha Homar, Nathalie Ubrich
Publikováno v:
Journal of microencapsulation. 24(7)
Celecoxib, a selective COX-2 inhibitor, primarily used in treatment of osteoarthritis, rheumatoid arthritis and acute pain was encapsulated in microparticles composed of various polyesters, polymethacrylates or cellulose derivatives used alone or ble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d641d6aa68dd4b4dab3c060d07c61e
https://pubmed.ncbi.nlm.nih.gov/17763056
https://pubmed.ncbi.nlm.nih.gov/17763056
Publikováno v:
Journal of microencapsulation. 24(1)
Incorporation of drugs in self-microemulsifying systems (SMES) offers several advantages for their delivery, the main one being faster drug dissolution and absorption. Formulation of SMES in solid dosage forms can be difficult and, to date, most SMES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0547ec7458637e21196bb91c91f31e1e
https://pubmed.ncbi.nlm.nih.gov/17438943
https://pubmed.ncbi.nlm.nih.gov/17438943
Autor:
Janez Kerc, Miha Homar
Publikováno v:
Scientia Pharmaceutica. 78:604-604
The enhancement of dissolution rate is one of the most commonly used approaches to improve the bioavailability of drugs, since for a great extent of new drug substances their absorption is limited with their dissolution rate. [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49a0ff2a9ca417c6474489572aa16160
https://doi.org/10.3797/scipharm.cespt.8.pdd15
https://doi.org/10.3797/scipharm.cespt.8.pdd15