Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Miguel X. Fernandes"'
Autor:
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 349-360 (2023)
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held togeth
Externí odkaz:
https://doaj.org/article/d1237b9cbbfb410ca4a715968aec2873
Autor:
Tereza Cristina Santos Evangelista, Óscar López, Adrián Puerta, Miguel X. Fernandes, Sabrina Baptista Ferreira, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2395-2402 (2022)
The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated as inhibitors against ace
Externí odkaz:
https://doaj.org/article/ab088dcc1fde417ebcc32bdfc2fb0a36
Autor:
Alma Fuentes-Aguilar, Penélope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, José Luis Vega-Báez, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, Andrea Petreni, Alessio Nocentini, Claudiu T. Supuran, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 168-177 (2022)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the
Externí odkaz:
https://doaj.org/article/a6eef15339bd494b8cace42877923ed9
Autor:
Mónica Martínez-Montiel, Laura L. Romero-Hernández, Simone Giovannuzzi, Paloma Begines, Adrián Puerta, Ana I. Ahuja-Casarín, Miguel X. Fernandes, Penélope Merino-Montiel, Sara Montiel-Smith, Alessio Nocentini, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños, Óscar López
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9401 (2023)
The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of these metalloenzymes a hot topic in current Medicinal Chemistry. In particular, CA IX and XII are membrane-bound enzymes, respons
Externí odkaz:
https://doaj.org/article/a4496264b52546eaa59e6d1a313ac174
Autor:
Ana I. Ahuja-Casarín, Penélope Merino-Montiel, José Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 138-146 (2021)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic
Externí odkaz:
https://doaj.org/article/c92efde9bb9247df94bfcbcfbdc69f9c
Autor:
Petko Alov, Merilin Al Sharif, Denitsa Aluani, Konstantin Chegaev, Jelena Dinic, Aleksandra Divac Rankov, Miguel X. Fernandes, Fabio Fusi, Alfonso T. García-Sosa, Risto Juvonen, Magdalena Kondeva-Burdina, José M. Padrón, Ilza Pajeva, Tania Pencheva, Adrián Puerta, Hannu Raunio, Chiara Riganti, Ivanka Tsakovska, Virginia Tzankova, Yordan Yordanov, Simona Saponara
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Sdox is a hydrogen sulfide (H2S)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox dru
Externí odkaz:
https://doaj.org/article/1c7deddbd8504d1eb6e324f730103fb1
Autor:
Giulia Arrighi, Adrián Puerta, Andrea Petrini, Francisco J. Hicke, Alessio Nocentini, Miguel X. Fernandes, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños, Óscar López
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7685 (2022)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in numerous tumors. (2) Methods: following the tail approach, we have appended
Externí odkaz:
https://doaj.org/article/11b43f6e67e04d8bac92f65f98a8dca1
Autor:
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 38:349-360
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held togeth
Autor:
José M. Padrón, Sara Montiel-Smith, José Luis Vega-Baez, Óscar López, José G. Fernández-Bolaños, Penélope Merino-Montiel, Inés Maya, Ana I Ahuja-Casarín, Miguel X. Fernandes, Irene Lagunes
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 138-146 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic
Autor:
Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L. Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X. Fernandes, Antonio J. Moreno-Vargas, José M. Padrón, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Bioorganic chemistry. 127
Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the synthesis and evaluation of new multitarget molecules. In particular, we have focused our attention on modulating the activity of