Comparative Proteomic Profiling of Ehrlichia ruminantium Pathogenic Strain and Its High-Passaged Attenuated Strain Reveals Virulence and Attenuation-Associated Proteins.

Autor: Isabel Marcelino, Miguel Ventosa, Elisabete Pires, Markus Müller, Frédérique Lisacek, Thierry Lefrançois, Nathalie Vachiery, Ana Varela Coelho

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145328 (2015)

The obligate intracellular bacterium Ehrlichia ruminantium (ER) causes heartwater, a fatal tick-borne disease in livestock. In the field, ER strains present different levels of virulence, limiting vaccine efficacy, for which the molecular basis remai

Externí odkaz: https://doaj.org/article/fbad31ceeba84b2da3ec6c000f02106b

Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model

Autor: Ana Rita Batista, Miguel Sena-Esteves, Davide Gianni, Maria João Saraiva, Miguel Ventosa, Ana Varela Coelho, Maria Rosário Almeida

Publikováno v: Gene Therapy. 21:1041-1050

Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disorder characterized by extracellular deposition of amyloid fibrils composed by mutated transthyretin (TTR) mainly in the peripheral nervous system. At present, liver transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2b9c209c281540b24baa1d5c4fa121
https://doi.org/10.1038/gt.2014.86

Proteomic profiling of the outer membrane fraction of the obligate intracellular bacterial pathogen ehrlichia ruminantium

Autor: Ana Varela Coelho, Olivier Gros, Isabel Marcelino, Damien F. Meyer, Thierry Lefrançois, Amal Moumène, Miguel Ventosa, Nathalie Vachiery

Publikováno v: Plos One 2 (10), . (2015)
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (2), pp.e0116758. ⟨10.1371/journal.pone.0116758⟩
PLoS ONE, Vol 10, Iss 2, p e0116758 (2015)
PloS One

International audience; The outer membrane proteins (OMPs) of Gram-negative bacteria play a crucial role in virulence and pathogenesis. Identification of these proteins represents an important goal for bacterial proteomics, because it aids in vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c47e6cb8836495a04f6e36d44c6cba
http://prodinra.inra.fr/record/320053

Omics approaches to study the Rickettsia Ehrlichia ruminantium: towards improved knowledge on Heartwater disease

Autor: Ludovic Pruneau, Damien F. Meyer, Miguel Ventosa, Elisabete Pires, André M. Almeida, Bernard Mari, Isabel Marcelino, Nathalie Vachiery, Ana Varela Coelho, Thierry Lefrançois

Publikováno v: Farm animal proteomics 2013 ISBN: 9789086867769

The Rickettsia Ehrlichia ruminantium is an obligate intracellular bacterium that causes Heartwater, a fatal tick-borne disease in ruminants, posing important economical constraints to livestock production in sub-Saharan Africa and in some Caribbean i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28d4680439f7e97ccf5bb321f79bf9af
https://doi.org/10.3920/978-90-8686-776-9_30

Tick-borne diseases in cattle: Applications of proteomics to develop new generation vaccines

Autor: Nathalie Vachiery, Miguel Ventosa, André M. Almeida, Damien F. Meyer, Ana Varela Coelho, Dominique Martinez, Ludovic Pruneau, Isabel Marcelino, Thierry Lefrançois

Publikováno v: Journal of Proteomics
Journal of Proteomics, Elsevier, 2012, 75 (14), pp.4232-4250. ⟨10.1016/j.jprot.2012.03.026⟩
Journal of Proteomics, 2012, 75 (14), pp.4232-4250. ⟨10.1016/j.jprot.2012.03.026⟩

International audience; Tick-borne diseases (TBDs) affect 80% of the world's cattle population, hampering livestock production throughout the world. Livestock industry is important to rural populations not only as food supply, but also as a source of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460d50fe1e952fb7fa6f3dafb02eb45e
https://hal.univ-antilles.fr/hal-02571127