Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Miguel Skirzewski"'
Autor:
Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M. Crooks, Gerard Kyungwook Kim, Sophie Henke Tarnow, Amy Reichelt, Sara Memar, Daniel Palmer, Yulong Li, R. Jane Rylett, Lisa M. Saksida, Vania F. Prado, Marco A. M. Prado, Timothy J. Bussey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Nucleus accumbens cholinergic interneurons release acetylcholine and glutamate. Here, authors show that acetylcholine, rather than glutamate, is predominantly involved in updating dopamine dynamics mediating Pavlovian approach behaviours.
Externí odkaz:
https://doaj.org/article/f4d1dc4e75374f81957db4a31c2850f0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
In the mammalian brain, information processing in sensory modalities and global mechanisms of multisensory integration facilitate perception. Emerging experimental evidence suggests that the contribution of multisensory integration to sensory percept
Externí odkaz:
https://doaj.org/article/eaa3a03aa3ff4e1f9970545e8b9fd540
Autor:
Raffaella De Pace, Miguel Skirzewski, Markus Damme, Rafael Mattera, Jeffrey Mercurio, Arianne M Foster, Loreto Cuitino, Michal Jarnik, Victoria Hoffmann, H Douglas Morris, Tae-Un Han, Grazia M S Mancini, Andrés Buonanno, Juan S Bonifacino
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007363 (2018)
The hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of disorders characterized by progressive lower limb spasticity. Mutations in subunits of the heterotetrameric (ε-β4-μ4-σ4) adaptor protein 4 (AP-4) com
Externí odkaz:
https://doaj.org/article/8d246468754b439990a8441def5315a5
Autor:
Larissa Erben, Jacqueline P. Welday, Marie E. Cronin, Ricardo Murphy, Miguel Skirzewski, Detlef Vullhorst, Steven L. Carroll, Andres Buonanno
Publikováno v:
J Neurochem
Neuregulins (NRGs) and their cognate neuronal receptor ERBB4, which is expressed in GABAergic and dopaminergic neurons, regulate numerous behaviors in rodents and have been identified as schizophrenia at-risk genes. ErbB4 transcripts are alternativel
Autor:
Jacqueline Anne Sullivan, Jinxia Wan, Lyle Muller, Yulong Li, Julie R. Dumont, Lisa M. Saksida, Timothy J. Bussey, Maryam H Mofrad, Sara Memar, Hassam Zafar Ansari, Miguel Skirzewski, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Brain and Mind Institute Researchers' Publications
© 2020 International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in high-level cognitive functions including memory,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b3b3a9fd9f68a217efa5609e3e1b99
https://ir.lib.uwo.ca/brainpub/296
https://ir.lib.uwo.ca/brainpub/296
Autor:
Simon Trinh, Miguel Skirzewski, Vania F. Prado, Ke Tan, Tongrui Qian, Wu Runlong, Lisa M. Saksida, Jianzhi Zeng, Shichen Zhang, Jing Zou, Wanling Peng, Pengcheng Huang, Li Y, Timothy J. Bussey, Min Xu, Liangyi Chen, Yulong Li, Miao Jing, Heping Cheng, Marco A. M. Prado, Haohong Li, Sunlei Pan, Samuel Andrew Hires, Ornela Kljakic
Publikováno v:
Brain and Mind Institute Researchers' Publications
Nature methods
Nature methods
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. The ability to directly measure acetylcholine (ACh) release is an essential step toward understanding its physiological function. Here we optimized the GRABACh (GPCR-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3102ccbbeb4407088d30af7dd9db51
https://ir.lib.uwo.ca/brainpub/369
https://ir.lib.uwo.ca/brainpub/369
Autor:
Ornela Kljakic, Pengcheng Huang, Shichen Zhang, Timothy J. Bussey, Ke Tan, Jianzhi Zeng, Miao Jing, Lisa M. Saksida, Min Xu, Heping Cheng, Tongrui Qian, Sunlei Pan, Miguel Skirzewski, Vania F. Prado, Li Y, Wu Runlong, Wanling Peng, Liangyi Chen, Marco A. M. Prado, Haohong Li, Yulong Li
The ability to directly measure acetylcholine (ACh) release is an essential first step towards understanding its physiological function. Here we optimized the GRABACh (GPCR-Activation–Based-ACh) sensor with significantly improved sensitivity and mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b5949932b5a6a98a0d6a73a4a143d2
https://doi.org/10.1101/861690
https://doi.org/10.1101/861690
Autor:
B. Sofia Beas, Andres Buonanno, Nicholas Ringelberg, Mario A. Penzo, Brandon J. Wright, Miguel Skirzewski, Jung Ho Hyun, Omar Koita, Hyung Bae Kwon, Yan Leng
Publikováno v:
Nature neuroscience
The paraventricular nucleus of the thalamus (PVT) is increasingly being recognized as a critical node linking stress detection to the emergence of adaptive behavioral responses to stress. However, despite growing evidence implicating the PVT in stres
Autor:
Veronica A. Alvarez, Kevin D. Hall, Alexxai V. Kravitz, Danielle M. Friend, Jeih-San Liow, Marcelo Rubinstein, Sushil G. Rane, Kavya Devarakonda, Ioannis Papazoglou, Alanna R Kaplan, Miguel Skirzewski, Juen Guo, Timothy J. O’Neal
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical in
Autor:
Marie E. Cronin, Alexxai V. Kravitz, Andres Buonanno, Ricardo Murphy, Miguel Skirzewski, Wambura C. Fobbs
Publikováno v:
eNeuro
Natural genetic variants of Neuregulin1 (NRG1) and its cognate receptor ErbB4 are associated with a risk for schizophrenia. Whereas most studies on NRG1-ErbB4 signaling have focused on GABAergic interneurons, ErbB4 is also expressed by midbrain dopam