Výsledky vyhledávání - "Miguel Rodríguez-Pulido"

Akademický článek

Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses

Autor: Miguel Rodríguez-Pulido, Eva Calvo-Pinilla, Miryam Polo, Juan-Carlos Saiz, Raúl Fernández-González, Eva Pericuesta, Alfonso Gutiérrez-Adán, Francisco Sobrino, Miguel A. Martín-Acebes, Margarita Sáiz

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a potentially severe respiratory disease, the coronavirus disease 2019 (COVID-19), an ongoing pandemic with limited therapeutic options. Here, we assessed the anti

Externí odkaz: https://doaj.org/article/a1847db1a91340a288ce637d47415cd8

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Akademický článek

Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health

Autor: Mar Forner, Rodrigo Cañas-Arranz, Sira Defaus, Patricia de León, Miguel Rodríguez-Pulido, Llilianne Ganges, Esther Blanco, Francisco Sobrino, David Andreu

Publikováno v: Vaccines, Vol 9, Iss 5, p 477 (2021)

Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from

Externí odkaz: https://doaj.org/article/28b5c1a4edbf4c5297f3b1d203cfe24f

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Akademický článek

Designing Functionally Versatile, Highly Immunogenic Peptide-Based Multiepitopic Vaccines against Foot-and-Mouth Disease Virus

Autor: Sira Defaus, Mar Forner, Rodrigo Cañas-Arranz, Patricia de León, María J. Bustos, Miguel Rodríguez-Pulido, Esther Blanco, Francisco Sobrino, David Andreu

Publikováno v: Vaccines, Vol 8, Iss 3, p 406 (2020)

A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV afforded by dendrimeric peptide structures ha

Externí odkaz: https://doaj.org/article/de36b3cfa13644fc98ccaa830e30e14c

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Akademický článek

Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation

Autor: Belén Borrego, Miguel Rodríguez-Pulido, Concepción Revilla, Belén Álvarez, Francisco Sobrino, Javier Domínguez, Margarita Sáiz

Publikováno v: Viruses, Vol 7, Iss 7, Pp 3954-3973 (2015)

The innate immune system is the first line of defense against viral infections. Exploiting innate responses for antiviral, therapeutic and vaccine adjuvation strategies is being extensively explored. We have previously described, the ability of small

Externí odkaz: https://doaj.org/article/b770e97f281542008efbd2646af6c10a

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Akademický článek

Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.

Autor: Miguel Rodríguez-Pulido, Miguel A Martín-Acebes, Estela Escribano-Romero, Ana-Belén Blázquez, Francisco Sobrino, Belén Borrego, Margarita Sáiz, Juan-Carlos Saiz

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49494 (2012)

West Nile virus (WNV) is a neurovirulent single stranded RNA mosquito-borne flavivirus, whose main natural hosts are birds, but it also infects humans and horses. Nowadays, no human vaccine is commercially available and clinical treatment is only sup

Externí odkaz: https://doaj.org/article/6c8a1c760ebc48398c96b4300cb2aa78

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Use of Foot-and-Mouth Disease Virus Non-coding Synthetic RNAs as Vaccine Adjuvants

Autor: Miguel, Rodríguez-Pulido, Miryam, Polo, Belén, Borrego, Margarita, Sáiz

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2465

The ncRNAs are short RNA transcripts with sequence and structure resembling that of specific domains in the non-coding regions of the foot-and-mouth disease (FMD) virus (FMDV ) genome. These synthetic molecules induce a robust antiviral response and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::950bcc22ec6b8470fb19a57d80c6bc42
https://pubmed.ncbi.nlm.nih.gov/35118619

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Use of Foot-and-Mouth Disease Virus Non-coding Synthetic RNAs as Vaccine Adjuvants

Autor: Miguel Rodríguez-Pulido, Miryam Polo, Belén Borrego, Margarita Sáiz

Publikováno v: Methods in Molecular Biology ISBN: 9781071621677
Digital.CSIC. Repositorio Institucional del CSIC
instname

125-136 pp
The ncRNAs are short RNA transcripts with sequence and structure resembling that of specific domains in the non-coding regions of the foot-and-mouth disease (FMD) virus (FMDV ) genome. These synthetic molecules induce a robust antivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb34cc169d2731355972640db35e442
https://doi.org/10.1007/978-1-0716-2168-4_7

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Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health

Autor: Patricia de León, Sira Defaus, Francisco Sobrino, Llilianne Ganges, Mar Forner, Miguel Rodríguez-Pulido, Rodrigo Cañas-Arranz, David Andreu, Esther Blanco

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Vaccines, Vol 9, Iss 477, p 477 (2021)
Vaccines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5d056199a1aa751e7fbe57fcb6f91
http://hdl.handle.net/10261/242474

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MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response

Autor: Margarita Sáiz, Francisco Sobrino, Miguel Rodríguez Pulido, Encarnación Martínez-Salas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 8, Pp 1-13 (2020)

The RIG-I-like receptor (RLR) melanoma differentiation-associated gene 5 (MDA5) plays a key role in triggering innate antiviral response during infection by RNA viruses. MDA5 activation leads to transcription induction of type-I interferon (IFN) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305103ea3dcdf759b6427e5712460561
https://doi.org/10.1038/s41419-020-02931-x

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A Wide-Ranging Antiviral Response in Wild Boar Cells Is Triggered by Non-coding Synthetic RNAs From the Foot-and-Mouth Disease Virus Genome

Autor: Margarita Sáiz, Ranjitha H B, Miguel Rodríguez Pulido

Publikováno v: Frontiers in Veterinary Science
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Veterinary Science, Vol 7 (2020)

Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious viral disease that affects multiple cloven-hooved hosts including important livestock (pigs, cattle, sheep and goats) as well as several wild animal species. Crossover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e7a11fd2a4a45f85be166859267fc2
http://europepmc.org/articles/PMC7417647

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