Výsledky vyhledávání - "Miguel Reyes-Mugica"

Akademický článek

A non-human primate model of acute liver failure suitable for testing liver support systems

Autor: Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t

Externí odkaz: https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394

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Akademický článek

Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants

Autor: Mylarappa Ningappa, Morayooluwa Adenuga, Kim A. Ngo, Nada Mohamed, Tejaswini Narayanan, Krishna Prasadan, Chethan Ashokkumar, Jishnu Das, Lori Schmitt, Hannah Hartman, Anuradha Sehrawat, Claudia M. Salgado, Miguel Reyes-Mugica, George K. Gittes, Cecilia W. Lo, Shankar Subramaniam, Rakesh Sindhi

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundCiliary defects cause heterogenous phenotypes related to mutation burden which lead to impaired development. A previously reported homozygous deletion in the Man1a2 gene causes lethal respiratory failure in newborn pups and decreased lung c

Externí odkaz: https://doaj.org/article/3f4d7397ddc74908a9f0fca602f5c229

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Akademický článek

Pervasive inflammatory activation in patients with deficiency in very‐long‐chain acyl‐coA dehydrogenase (VLCADD)

Autor: Abbe N Vallejo, Henry J Mroczkowski, Joshua J Michel, Michael Woolford, Harry C Blair, Patricia Griffin, Elizabeth McCracken, Stephanie J Mihalik, Miguel Reyes‐Mugica, Jerry Vockley

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)

Abstract Objectives Very‐long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) is a disorder of fatty acid oxidation. Symptoms are managed by dietary supplementation with medium‐chain fatty acids that bypass the metabolic block. However, pati

Externí odkaz: https://doaj.org/article/4f87441ed51b43d09fe36d6b7d486fdd

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Akademický článek

Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotype.

Autor: Dipanjan Basu, Miguel Reyes-Mugica, Abdelhadi Rebbaa

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52188 (2012)

Cellular senescence is considered as a tumor suppressive mechanism. Recent evidence indicates however that senescent cells secrete various growth factors and cytokines, some of which may paradoxically promote cancer progression. This phenomenon terme

Externí odkaz: https://doaj.org/article/e7023e2a240e4be589a30e5ac82ca0b2

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Data from Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-β, and Wnt Signaling Pathways

Autor: Abdelhadi Rebbaa, Miguel Reyes-Mugica, Susan Strellec, Krishnan Damodaran, Robert Lettan, Dipanjan Basu

Embryonic signaling pathways, in particular those mediated by Wnt and TGF-β, are known to play key roles in tumor progression through the induction of epithelial–mesenchymal transition (EMT). Their simultaneous targeting could therefore represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be5096db8eb5b095dc27181da5a56cc
https://doi.org/10.1158/1535-7163.c.6536382

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