Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Miguel Reyes Parada"'
Autor:
José A. Pino, Gabriel Nuñez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The dopamine transporter (DAT) plays a crucial role in the regulation of brain dopamine (DA) homeostasis through the re-uptake of DA back into the presynaptic terminal. In addition to re-uptake, DAT is also able to release DA through a process referr
Externí odkaz:
https://doaj.org/article/a9c98e7752c54cb9b32191454617d4fc
Autor:
Valeska Cid-Jofré, Tamara Bahamondes, Agustina Zúñiga Correa, Ivalú Ahumada Arias, Miguel Reyes-Parada, Georgina M. Renard
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Mounting evidence from animal models and human studies indicates that psychostimulants can significantly affect social behaviors. This is not surprising considering that the neural circuits underlying the regulation and expression of social behaviors
Externí odkaz:
https://doaj.org/article/fbed30c35d4a4c758ca45f5e8b0641c9
Autor:
Alejandro Valdés-Jiménez, Daniel Jiménez-González, Aytug K. Kiper, Susanne Rinné, Niels Decher, Wendy González, Miguel Reyes-Parada, Gabriel Núñez-Vivanco
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of no
Externí odkaz:
https://doaj.org/article/197170dac86541658f2b64ec95dd9c6f
Autor:
Gabriel Quiroz, Ramón Sotomayor-Zárate, Juan Pablo González-Gutierrez, Franco Vizcarra, Felipe Moraga, Isabel Bermudez, Miguel Reyes-Parada, María Elena Quintanilla, Diego Lagos, Mario Rivera-Meza, Patricio Iturriaga-Vásquez
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Brain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of pentameric acetylcholine-gated cation channels, have been suggested as molecular targets for the treatment of alcohol abuse and dependence. Here, we examined the effect of th
Externí odkaz:
https://doaj.org/article/205bae793a904fdc952bd2c097feaf04
Autor:
Christopher Cerda-Cavieres, Gabriel Quiroz, Patricio Iturriaga-Vásquez, Julio Rodríguez-Lavado, Jazmín Alarcón-Espósito, Claudio Saitz, Carlos D. Pessoa-Mahana, Hery Chung, Ramiro Araya-Maturana, Jaime Mella-Raipán, David Cabezas, Claudia Ojeda-Gómez, Miguel Reyes-Parada, Hernán Pessoa-Mahana
Publikováno v:
Molecules, Vol 25, Iss 20, p 4614 (2020)
A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a–o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fl
Externí odkaz:
https://doaj.org/article/ad09736e79234c8b9134bb4e5a5f08f2
Autor:
Gabriel Núñez-Vivanco, Angélica Fierro, Pablo Moya, Patricio Iturriaga-Vásquez, Miguel Reyes-Parada
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200637 (2018)
The study of binding site similarities can be relevant to understand the interaction of different drugs at several molecular targets. The increasing availability of protein crystal structures and the development of novel algorithms designed to evalua
Externí odkaz:
https://doaj.org/article/7b5a8916c3d64e4f868707fda299f4de
Autor:
Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez
Publikováno v:
Molecules, Vol 24, Iss 15, p 2684 (2019)
Neuronal α4β2 nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels (LGIC) that have been implicated in nicotine addiction, reward, cognition, pain disorders, anxiety, and depression. Nicotine has been widely used as a template f
Externí odkaz:
https://doaj.org/article/838d686b3ffa4812a112c5c2aef46ae7
Autor:
Camila Narbondo, Miguel Reyes-Parada, Xavier Nadal, Verónica Sánchez de Medina, Giselle Prunell, Carolina Echeverry, Cecilia Scorza
Publikováno v:
Neurotoxicity Research. 39:335-348
Previous preclinical studies have demonstrated that cannabidiol (CBD) and cannabigerol (CBG), two non-psychotomimetic phytocannabinoids from Cannabis sativa, induce neuroprotective effects on toxic and neurodegenerative processes. However, a comparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350fceb97dfcf21d03e39e2ba0115310
https://doi.org/10.1007/s12640-020-00277-y
https://doi.org/10.1007/s12640-020-00277-y
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12077, p 12077 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411c8e119a09c5f3d152bf77fa0a9dbc
https://www.mdpi.com/1422-0067/22/21/12077
https://www.mdpi.com/1422-0067/22/21/12077
Autor:
Patricia Möller-Acuña, J Sebastián Contreras-Riquelme, Cecilia Rojas-Fuentes, Gabriel Nuñez-Vivanco, Jans Alzate-Morales, Patricio Iturriaga-Vásquez, Hugo R Arias, Miguel Reyes-Parada
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134444 (2015)
Evidence from systems biology indicates that promiscuous drugs, i.e. those that act simultaneously at various protein targets, are clinically better in terms of efficacy, than those that act in a more selective fashion. This has generated a new trend
Externí odkaz:
https://doaj.org/article/b6ff2c52ab2c48fc83667a7baf5fbae6