Výsledky vyhledávání - "Miguel Retamal"

In vitro and in vivo evidence of a potential A(H1N1)pdm09 antigenic drift mediated by escape mutations in the haemagglutinin Sa antigenic site

Autor: Guy Boivin, Chantal Rhéaume, Yacine Abed, Miguel Retamal, Mariana Baz

Publikováno v: Journal of General Virology. 98:1224-1231

Influenza A(H1N1)pdm09 virus continues to circulate worldwide without evidence of significant antigenic drift between 2009 and 2016. By using escape mutants, we previously identified six haemagglutinin (HA) changes (T80R, G143E, G158E, N159D, K166E a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6441bf6bfac61983d08980ed82d7a378
https://doi.org/10.1099/jgv.0.000800

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The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models

Autor: Corey P. Mallett, Xavier Bouhy, Marie-Hélène Joly, Chantal Rhéaume, Guy Boivin, Andrés Pizzorno, Edith Beaulieu, Laurent Kaiser, Arnaud G L'Huillier, Clément Fage, Miguel Retamal, Yacine Abed, Karen Dubé

Publikováno v: Antiviral Research, Vol. 132 (2016) pp. 6-12

We recently isolated an influenza A(H1N1)pdm09 E119D/H275Y neuraminidase (NA) variant from an immunocompromised patient who received oseltamivir and zanamivir therapies. This variant demonstrated cross resistance to zanamivir, oseltamivir, peramivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be124877c168ddadcb251ca3a87e58f0
https://doi.org/10.1016/j.antiviral.2016.05.006

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Heterosubtypic Protection Conferred by the Human Monoclonal Antibody PN-SIA28 against Influenza A Virus Lethal Infections in Mice

Autor: Yacine Abed, Chantal Rhéaume, Massimo Clementi, Francesca Cappelletti, Nicola Clementi, Nicasio Mancini, Miguel Retamal, Guy Boivin, Roberto Burioni

Publikováno v: Antimicrobial Agents and Chemotherapy. 59:2647-2653

PN-SIA28 is a human monoclonal antibody (Hu-MAb) targeting highly conserved epitopes within the stem portion of the influenza virus hemagglutinin (HA) (N. Clementi, et al, PLoS One 6:e28001, 2011, http://dx.doi.org/10.1371/journal.pone.0028001). Prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2e32ea4e11855593e624e7a0ee947b
https://doi.org/10.1128/aac.00118-15

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Epitope mapping of the 2009 pandemic and the A/Brisbane/59/2007 seasonal (H1N1) influenza virus haemagglutinins using mAbs and escape mutants

Autor: Guy Boivin, Yacine Abed, Jacques Corbeil, Miguel Retamal

Publikováno v: The Journal of general virology. 95(Pt 11)

mAbs constitute an important biological tool for influenza virus haemagglutinin (HA) epitope mapping through the generation of escape mutants, which could provide insights into immune evasion mechanisms and may benefit the future development of vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f3ec20a831651930ea520b27512283
https://pubmed.ncbi.nlm.nih.gov/25078301

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