Výsledky vyhledávání - "Miguel Pinilla-Vera"

Akademický článek

mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury

Publikováno v: JCI Insight, Vol 6, Iss 14 (2021)

The acute respiratory distress syndrome (ARDS) is a highly lethal condition that impairs lung function and causes respiratory failure. Mechanical ventilation (MV) maintains gas exchange in patients with ARDS but exposes lung cells to physical forces

Externí odkaz: https://doaj.org/article/046048147d16480695cff473141c80c1

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Akademický článek

Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.

Autor: Miguel Pinilla-Vera, Zeyu Xiong, Yutong Zhao, Jing Zhao, Michael P Donahoe, Suchitra Barge, William T Horne, Jay K Kolls, Bryan J McVerry, Anastasiya Birukova, Robert M Tighe, W Michael Foster, John Hollingsworth, Anuradha Ray, Rama Mallampalli, Prabir Ray, Janet S Lee

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159329 (2016)

Despite recent advances in understanding macrophage activation, little is known regarding how human alveolar macrophages in health calibrate its transcriptional response to canonical TLR4 activation. In this study, we examined the full spectrum of LP

Externí odkaz: https://doaj.org/article/ef02527a842b489e8b337410d2604e08

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Akademický článek

Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut

Autor: Jack Varon, MD, MBA, Antonio Arciniegas Rubio, MD, Diana Amador-Munoz, MD, Alexis Corcoran, BA, Joseph A. DeCorte, BS, Colleen Isabelle, BA, Miguel Pinilla Vera, MD, Katherine Walker, MD, MSc, Luke Brown, BSc, Manuela Cernadas, MD, Lynn Bry, MD, PhD, Haopu Yang, Georgios D. Kitsios, MD, PhD, Bryan J. McVerry, MD, Alison Morris, MD, MS, Hyunwook Lee, BA, Judie Howrylak, MD, PhD, Joshua A. Englert, MD, Rebecca M. Baron, MD

Publikováno v: Critical Care Explorations, Vol 4, Iss 5, p e0699 (2022)

OBJECTIVES:. Determine the role of surfactant protein D (SPD) in sepsis. DESIGN:. Murine in vivo study. SETTING:. Research laboratory at an academic medical center. PATIENTS:. SPD knockout (SPD−/−) and wild-type (SPD+/+) mice. INTERVENTIONS:. SPD

Externí odkaz: https://doaj.org/article/6ca943f89eaf4aab8b566e2dfd90048f

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Acute myopericarditis as a cause of isolated right ventricular failure

Autor: Miguel Pinilla-Vera, Wendy Ying, Sammy Zakaria

Publikováno v: Future Cardiology. 16:171-178

Myopericarditis is characterized by pericardial and myocardial inflammation and is a known cause of chest pain and heart failure. It is primarily associated with biventricular or left ventricular dysfunction. We describe an unusual case of a 57-year-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d11c7321dbb910ff3514658ac225b7d
https://doi.org/10.2217/fca-2019-0019

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Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction

Autor: Miguel Pinilla-Vera, David A. Kass, Virginia S. Hahn

Publikováno v: Circ Res

Advances in the treatment of heart failure with reduced ejection fraction due to systolic dysfunction are engaging an ever-expanding compendium of molecular signaling targets. Well established approaches modifying hemodynamics and cell biology by neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4d683739f9f30077a05f3d67882b88
https://doi.org/10.1161/circresaha.119.313682

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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Autor: Masayuki Sasaki, Christian U. Oeing, Dong Ik Lee, Djahida Bedja, Mark J. Ranek, Taishi Nakamura, Jonathan D. Powell, Jennifer E. Van Eyk, Chirag H. Patel, Anna Chen, Miguel Pinilla Vera, Ronald J. Holewinski, Kristen M. Kokkonen-Simon, Guangshuo Zhu, David A. Kass, Brittany Dunkerly-Eyring

Publikováno v: Nature

The mechanistic target of rapamycin complex-1 (mTORC1) coordinates regulation of growth, metabolism, protein synthesis and autophagy1. Its hyperactivation contributes to disease in numerous organs, including the heart1,2, although broad inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ccf5739aaa5a72e9b1e7524e814d8
https://doi.org/10.1038/s41586-019-0895-y

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Abstract 346: Tuberin S1365 Phosphorylation Regulates Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathological Signaling While Sustaining Metabolic Sensor Function

Autor: Christian U. Oeing, Brittany Dunkerly-Eyring, David A. Kass, Mark J. Ranek, Miguel Pinilla Vera

Publikováno v: Circulation Research. 125

Rationale: The Mechanistic Target of Rapamycin complex 1 (mTORC1) integrates signaling and sensory inputs to maintain cardiomyocyte homeostasis, and itself is negatively regulated by the signaling nexus tuberin (TSC2). We identified a novel TSC2 phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72431743e06acbdd6c58f15a42a17765
https://doi.org/10.1161/res.125.suppl_1.346

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Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy

Autor: Diana Amador-Munoz, Bruce D. Levy, Lidan Wu, Miguel Pinilla Vera, Jongyoon Han, Anna Coronata, Han Wei Hou, Rebecca M. Baron, Joshua A. Englert

Publikováno v: PMC

Sepsis represents a systemic inflammatory response caused by microbial infection in blood. Herein, we present a novel comprehensive approach to mitigate inflammatory responses through broad spectrum removal of pathogens, leukocytes and cytokines base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f029e0cb2cbb9a371640d329fb8884
https://doi.org/10.1039/c5lc01110h

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