Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Miguel O. Mitchell"'
Autor:
John A. Means, Miguel O. Mitchell
Publikováno v:
Journal of Chemical Education. 95:2284-2288
Although the potent effects of cation−π interactions for stabilizing protein structure and binding ligands to proteins have been reported in the chemical literature for over two decades, there are no undergraduate biochemistry textbooks covering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b600ad52497a22d0453606234d51fded
https://doi.org/10.1021/acs.jchemed.8b00426
https://doi.org/10.1021/acs.jchemed.8b00426
Autor:
Miguel O. Mitchell
Publikováno v:
Journal of molecular modeling. 23(10)
The chalcogen bond, the noncovalent, electrostatic attraction between covalently bonded atoms in group 16 and Lewis bases, is present in protein-ligand interactions based on X-ray structures deposited in the Protein Data Bank (PDB). Discovering prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe3ee25ddfb22e5b84dfd5cd4d6ff60
https://pubmed.ncbi.nlm.nih.gov/28942498
https://pubmed.ncbi.nlm.nih.gov/28942498
Autor:
Miguel O. Mitchell
Publikováno v:
Anti-Infective Agents in Medicinal Chemistry. 6:243-247
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a721d753ae076034a02d86ab31556af1
https://doi.org/10.2174/187152107782023114
https://doi.org/10.2174/187152107782023114
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
Quaternized triflupromazine derivatives (QTDs) must possess benzyl groups attached to the quaternary nitrogen in order to have significant antitubercular potency. Replacing the quaternary amine with a triazole abolishes antitubercular activity. A mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4e80df6c621f5498e9856129e0d9fe
https://pubmed.ncbi.nlm.nih.gov/22850215
https://pubmed.ncbi.nlm.nih.gov/22850215
Autor:
Ashley Roe, Shao-Chung Hsia, Akasha K. Purohit, Jacob J. Leichty, Lori M. Ward, Matthew Balish, Miguel O. Mitchell
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(16)
N-(4-chlorobenzyl)triflupromazinium chloride, a known antitubercular agent, has been found to also be active against HSV-1. A preliminary structure-activity relation has been explored to determine which groups are crucial to viral inhibition. Antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2bdb11c63c36b96a732d2f32e31e58
https://pubmed.ncbi.nlm.nih.gov/22789428
https://pubmed.ncbi.nlm.nih.gov/22789428
Autor:
Miguel O. Mitchell, P. W. Le Quesne
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::513024d15043b651b194c775dbff2259
https://doi.org/10.1002/chin.199112331
https://doi.org/10.1002/chin.199112331
Publikováno v:
ChemInform. 25
Thiomethylation of indole and haloindoles has been achieved via their zinc salts. This one-pot reaction uses methyl disulfide as electrophile. Isolation of thiomethylated indole products in moderate yields requires the addition of a thiol (e.g., cyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0f35a317f3e80510c5546386f3414d
https://doi.org/10.1002/chin.199413165
https://doi.org/10.1002/chin.199413165
Publikováno v:
ChemInform. 27
Deoxypseudophrynaminol, 1 , is a potent antibacterial agent that inhibits the in vitro growth of vancomycin-resistant Enterococci and methicillin-resistant Staphylococcus aureus with MIC values ⩽40 μg/mL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c4bec657a685aa89533cb639b62b54
https://doi.org/10.1002/chin.199609268
https://doi.org/10.1002/chin.199609268
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 6(3)
Selective human butyrylcholinesterase (BChE) inhibitors such as cymserine have shown considerable promise for restoring cognition in Alzheimer's disease. Recently, (-)-debromoflustramine B, 1, a hexahydropyrrolo-[2,3-b]indole natural product isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d35cdfe17231e058a7b328fa812665c
https://pubmed.ncbi.nlm.nih.gov/20632975
https://pubmed.ncbi.nlm.nih.gov/20632975
Autor:
Miguel O. Mitchell
A tripartate prodrug of S-trityl-L-cysteine was synthesized and investigated for antiprostatic potency versus the free anticancer agent (S-trityl-L-cysteine) in PSA-secreting cells (LNCap) and non-PSA-secreting cells (PC3). The prodrug did not inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7222848c9a7d3334ebef1948120065c
https://doi.org/10.21236/ada488600
https://doi.org/10.21236/ada488600
