Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Miguel Munoz Gomez"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 17, Iss , Pp 108-113 (2019)
Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood. Here, we ex
Externí odkaz:
https://doaj.org/article/3c614410cd9f470f81e7685f07101767
Autor:
Agostina Nardone, Xintao Qiu, Sandor Spisak, Zsuzsanna Nagy, Ariel Feiglin, Avery Feit, Gabriela Cohen Feit, Yingtian Xie, Alba Font-Tello, Cristina Guarducci, Francisco Hermida-Prado, Sudeepa Syamala, Klothilda Lim, Miguel Munoz Gomez, Matthew Pun, MacIntosh Cornwell, Weihan Liu, Aysegul Ors, Hisham Mohammed, Paloma Cejas, Jane B. Brock, Matthew L. Freedman, Eric P. Winer, Xiaoyong Fu, Rachel Schiff, Henry W. Long, Otto Metzger Filho, Rinath Jeselsohn
Publikováno v:
Cancer Res
Most invasive lobular breast cancers (ILC) are of the luminal A subtype and are strongly hormone receptor–positive. Yet, ILC is relatively resistant to tamoxifen and associated with inferior long-term outcomes compared with invasive ductal cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ba56c1184a5cedf045c241e017be95
https://doi.org/10.1158/0008-5472.can-21-3186
https://doi.org/10.1158/0008-5472.can-21-3186
Autor:
Rinath Jeselsohn, Otto Metzger Filho, Henry W. Long, Rachel Schiff, Xiaoyong Fu, Eric P. Winer, Matthew L. Freedman, Jane B. Brock, Paloma Cejas, Hisham Mohammed, Aysegul Ors, Weihan Liu, MacIntosh Cornwell, Matthew Pun, Miguel Munoz Gomez, Klothilda Lim, Sudeepa Syamala, Francisco Hermida-Prado, Cristina Guarducci, Alba Font-Tello, Yingtian Xie, Gabriela Cohen Feit, Avery Feit, Ariel Feiglin, Zsuzsanna Nagy, Sandor Spisak, Xintao Qiu, Agostina Nardone
Supplementary Table from A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644d4a0422e250cec5f0ba2f7557a6cc
https://doi.org/10.1158/0008-5472.22432398
https://doi.org/10.1158/0008-5472.22432398
Autor:
Rinath Jeselsohn, Otto Metzger Filho, Henry W. Long, Rachel Schiff, Xiaoyong Fu, Eric P. Winer, Matthew L. Freedman, Jane B. Brock, Paloma Cejas, Hisham Mohammed, Aysegul Ors, Weihan Liu, MacIntosh Cornwell, Matthew Pun, Miguel Munoz Gomez, Klothilda Lim, Sudeepa Syamala, Francisco Hermida-Prado, Cristina Guarducci, Alba Font-Tello, Yingtian Xie, Gabriela Cohen Feit, Avery Feit, Ariel Feiglin, Zsuzsanna Nagy, Sandor Spisak, Xintao Qiu, Agostina Nardone
Supplementary Figure from A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3f88a0fff75196b0b08116e20f8d54
https://doi.org/10.1158/0008-5472.22432410.v1
https://doi.org/10.1158/0008-5472.22432410.v1
Data from A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Autor:
Rinath Jeselsohn, Otto Metzger Filho, Henry W. Long, Rachel Schiff, Xiaoyong Fu, Eric P. Winer, Matthew L. Freedman, Jane B. Brock, Paloma Cejas, Hisham Mohammed, Aysegul Ors, Weihan Liu, MacIntosh Cornwell, Matthew Pun, Miguel Munoz Gomez, Klothilda Lim, Sudeepa Syamala, Francisco Hermida-Prado, Cristina Guarducci, Alba Font-Tello, Yingtian Xie, Gabriela Cohen Feit, Avery Feit, Ariel Feiglin, Zsuzsanna Nagy, Sandor Spisak, Xintao Qiu, Agostina Nardone
Most invasive lobular breast cancers (ILC) are of the luminal A subtype and are strongly hormone receptor–positive. Yet, ILC is relatively resistant to tamoxifen and associated with inferior long-term outcomes compared with invasive ductal cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f4303f8d7b93b042806e9b013252f7
https://doi.org/10.1158/0008-5472.c.6514143.v1
https://doi.org/10.1158/0008-5472.c.6514143.v1
Autor:
Rinath Jeselsohn, Otto Metzger Filho, Henry W. Long, Rachel Schiff, Xiaoyong Fu, Eric P. Winer, Matthew L. Freedman, Jane B. Brock, Paloma Cejas, Hisham Mohammed, Aysegul Ors, Weihan Liu, MacIntosh Cornwell, Matthew Pun, Miguel Munoz Gomez, Klothilda Lim, Sudeepa Syamala, Francisco Hermida-Prado, Cristina Guarducci, Alba Font-Tello, Yingtian Xie, Gabriela Cohen Feit, Avery Feit, Ariel Feiglin, Zsuzsanna Nagy, Sandor Spisak, Xintao Qiu, Agostina Nardone
Supplementary Data from A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a879610994dcc5dfe48362fca7af8d
https://doi.org/10.1158/0008-5472.22432422
https://doi.org/10.1158/0008-5472.22432422
Autor:
Brian Lu, Kiran Kurmi, Miguel Munoz-Gomez, Egon J. Jacobus Ambuludi, Jason M. Tonne, Kuntol Rakshit, Taro Hitosugi, Yogish C. Kudva, Aleksey V. Matveyenko, Yasuhiro Ikeda
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the live
Externí odkaz:
https://doaj.org/article/0c89c06a4b914af2b1f022f577abb704
Autor:
Jason M. Tonne, Toshie Sakuma, Michael C. Deeds, Miguel Munoz-Gomez, Michael A. Barry, Yogish C. Kudva, Yasuhiro Ikeda
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1236-1245 (2013)
SUMMARY Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. Glucagon-like peptide-1 (GLP-1) has β-cell protective effects an
Externí odkaz:
https://doaj.org/article/7d81d4fcdf9643f88421ebc9f2dc8274
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 17, Iss, Pp 108-113 (2019)
Biochemistry and Biophysics Reports, Vol 17, Iss, Pp 108-113 (2019)
Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood. Here, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3760d01f255aa63071bb108b3ad5a7cf
https://doi.org/10.1016/j.bbrep.2018.12.002
https://doi.org/10.1016/j.bbrep.2018.12.002
Publikováno v:
Biological Chemistry. 399:565-576
Glucokinase (GCK) is crucial to regulating glucose metabolism in the liver and in pancreatic β-cells. There are two major GCK isoforms, hepatic and pancreatic GCKs, which differ only in exon 1. However, the functional differences between the two GCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db76ee101888561e0801da328d38a5f3
https://doi.org/10.1515/hsz-2018-0109
https://doi.org/10.1515/hsz-2018-0109