Mendelian randomization confirms the role of Y-chromosome loss in Alzheimer’s Disease etiopathogenesis in males

Autor: Pablo García-González, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcón-Martín, Inés Quintela, Adela Orellana, Victor Andrade, Pamela Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, María Teresa Periñán, Ignacio Alvarez, Monica Diez-Fairen, Raul Nuñez Llaves, Claudia Olivé Roig, Guillermo Garcia-Ribas, Manuel Menéndez-González, Carmen Martínez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macías, Maria Eugenia Saez, Amanda Cano, Maria Bullido, Luis Real, Eloy Rodríguez-Rodríguez, Jose Royo, Victoria Álvarez, Pau Pastor, Gerard Piñol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sánchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tàrraga, Alfredo Ramirez, Mercé Boada, Agustín Ruiz

Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event occurring exclusively in men and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0776da9c7058f00bf016db6381df5afb
https://doi.org/10.1101/2022.07.20.22277657

Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men.

Autor: García-González, Pablo^1,2 (AUTHOR), de Rojas, Itziar^1,2 (AUTHOR), Moreno-Grau, Sonia^1,3 (AUTHOR), Montrreal, Laura¹ (AUTHOR), Puerta, Raquel¹ (AUTHOR), Alarcón-Martín, Emilio¹ (AUTHOR), Quintela, Inés⁴ (AUTHOR), Orellana, Adela¹ (AUTHOR), Andrade, Victor^5,6 (AUTHOR), Adami, Pamela V. Martino⁵ (AUTHOR), Heilmann-Heimbach, Stefanie⁷ (AUTHOR), Gomez-Garre, Pilar^2,8 (AUTHOR), Periñán, María Teresa^2,8 (AUTHOR), Alvarez, Ignacio^9,10 (AUTHOR), Diez-Fairen, Monica^9,10 (AUTHOR), Nuñez Llaves, Raul¹ (AUTHOR), Olivé Roig, Claudia¹ (AUTHOR), Garcia-Ribas, Guillermo¹¹ (AUTHOR), Menéndez-González, Manuel^12,13,14 (AUTHOR), Martínez, Carmen^13,15 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 2, p898. 17p.

Studies from International University of Catalunya in the Area of Alzheimer Disease Described (Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men).

Publikováno v: Genomics & Genetics Weekly; 2/10/2023, p2373-2373, 1p