Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Miguel Machuqueiro"'
Autor:
Iris C. Salaroglio, Denitsa Stefanova, Ricardo G. Teixeira, Nuno F.B. Oliveira, Amer Ahmed, Fabio Fusi, Virginia Tzankova, Yordan Yordanov, Miguel Machuqueiro, Simona Saponara, Andreia Valente, Chiara Riganti
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107353- (2024)
The therapeutic approach to many solid tumors, including non-small cell lung cancer (NSCLC), is mainly based on the use of platinum-containing anticancer agents and is often characterized by acquired or intrinsic resistance to the drug. Therefore, th
Externí odkaz:
https://doaj.org/article/2f88abcebe004d218abfc467fccfd25d
Autor:
Beatriz Bueschbell, Pedro R. Magalhães, Carlos A.V. Barreto, Rita Melo, Anke C. Schiedel, Miguel Machuqueiro, Irina S. Moreira
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4336-4353 (2023)
G protein-coupled receptors (GPCRs) are known to dimerize, but the molecular and structural basis of GPCR dimers is not well understood. In this study, we developed a computational framework to generate models of symmetric and asymmetric GPCR dimers
Externí odkaz:
https://doaj.org/article/2c5100c6630647dcac9e0546876e59bc
Publikováno v:
BBA Advances, Vol 4, Iss , Pp 100099- (2023)
Several factors affect the passive membrane permeation of small molecules, including size, charge, pH, or the presence of specific chemical groups. Understanding these features is paramount to identifying or designing drug candidates with optimal ADM
Externí odkaz:
https://doaj.org/article/fdb080e38cbe4ba49b9e278d1935f04d
Autor:
Patrícia T. Borges, Diogo Silva, Tomás F.D. Silva, Vânia Brissos, Marina Cañellas, Maria Fátima Lucas, Laura Masgrau, Eduardo P. Melo, Miguel Machuqueiro, Carlos Frazão, Lígia O. Martins
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 22, Iss , Pp 2- (2023)
Externí odkaz:
https://doaj.org/article/26503200f21247e5bf9087c5d5674614
Autor:
Patrícia T. Borges, Diogo Silva, Tomás F.D. Silva, Vânia Brissos, Marina Cañellas, Maria Fátima Lucas, Laura Masgrau, Eduardo P. Melo, Miguel Machuqueiro, Carlos Frazão, Lígia O. Martins
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3899-3910 (2022)
DyP-type peroxidases (DyPs) are microbial enzymes that catalyze the oxidation of a wide range of substrates, including synthetic dyes, lignin-derived compounds, and metals, such as Mn2+ and Fe2+, and have enormous biotechnological potential in bioref
Externí odkaz:
https://doaj.org/article/ff8a63eb5f1e4897b6318690ddd37c7f
Autor:
Mykola V. Rodnin, Victor Vasques-Montes, Alexander Kyrychenko, Nuno F. B. Oliveira, Maithri M. Kashipathy, Kevin P. Battaile, Justin Douglas, Scott Lovell, Miguel Machuqueiro, Alexey S. Ladokhin
Publikováno v:
Toxins, Vol 15, Iss 7, p 410 (2023)
Protonation of key histidine residues has been long implicated in the acid-mediated cellular action of the diphtheria toxin translocation (T-) domain, responsible for the delivery of the catalytic domain into the cell. Here, we use a combination of c
Externí odkaz:
https://doaj.org/article/e62e1a5ad3bb4daab95b0257006a04fb
Autor:
Nuno F.B. Oliveira, Filipe E.P. Rodrigues, João N.M. Vitorino, Rui J.S. Loureiro, Patrícia F.N. Faísca, Miguel Machuqueiro
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5160-5169 (2021)
The D76N mutant of the β2m protein is a biologically motivated model system to study protein aggregation. There is strong experimental evidence, supported by molecular simulations, that D76N populates a highly dynamic conformation (which we original
Externí odkaz:
https://doaj.org/article/b3d9a5dde46140eaaf04f864710918e0
Autor:
Maria João Álvaro-Martins, Violeta Railean, Filomena Martins, Miguel Machuqueiro, Rita Pacheco, Susana Santos
Publikováno v:
Molecules, Vol 28, Iss 4, p 1877 (2023)
Cancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Melanoma is a highly aggressive skin tumor with an increasing incidence and poor prognosis i
Externí odkaz:
https://doaj.org/article/1006f2d5695d4a13b3f4e0fd8fff3e66
Autor:
Catarina Frazão de Faria, Tânia Moreira, Pedro Lopes, Henrique Costa, Jessica R. Krewall, Callie M. Barton, Susana Santos, Douglas Goodwin, Diana Machado, Miguel Viveiros, Miguel Machuqueiro, Filomena Martins
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112362- (2021)
Isoniazid (INH) is one of the two most effective first-line antitubercular drugs and is still used at the present time as a scaffold for developing new compounds to fight TB. In a previous study, we have observed that an INH derivative, an hydrazide
Externí odkaz:
https://doaj.org/article/77aea5961a6b413c9ab4b7c7f8177256
Autor:
Claudia Istrate, Jéssica Marques, Pedro Bule, Sílvia Correia, Frederico Aires-da-Silva, Marlene Duarte, Ana Luísa Reis, Miguel Machuqueiro, Alexandre Leitão, Bruno L. Victor
Publikováno v:
Viruses, Vol 14, Iss 11, p 2348 (2022)
African swine fever virus (ASFV) is the etiological agent of a highly contagious, hemorrhagic infectious swine disease, with a tremendous sanitary and economic impact on a global scale. Currently, there are no globally available vaccines or treatment
Externí odkaz:
https://doaj.org/article/f3252d7cafb54d978fbf47db433d8349