Zobrazeno 1 - 10 of 187 pro vyhledávání: '"Miguel López Botet"'
1
Akademický článek
NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer
Autor: Sara Santana-Hernández, Jesús Suarez-Olmos, Sonia Servitja, Pau Berenguer-Molins, Marcel Costa-Garcia, Laura Comerma, Anna Rea, Julia Perera-Bel, Silvia Menendez, Oriol Arpí, Begoña Bermejo, María Teresa Martínez, Juan Miguel Cejalvo, Iñaki Comino-Méndez, Javier Pascual, Emilio Alba, Miguel López-Botet, Federico Rojo, Ana Rovira, Joan Albanell, Aura Muntasell
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts to personalized clinical management and the development of innovative treatment strategies. Tumor-infiltrating Natural Killer (TI-NK) cells ca
Externí odkaz: https://doaj.org/article/5bc22c2f73dc42618cc14ecab70aa357
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2
Akademický článek
Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis
Autor: Ana Zabalza, Andrea Vera, Elisenda Alari-Pahissa, Elvira Munteis, Antía Moreira, Jose Yélamos, Mireia Llop, Miguel López-Botet, Jose E. Martínez-Rodríguez
Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-8 (2020)
Abstract Background Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in MS patients whether H
Externí odkaz: https://doaj.org/article/31965209bd944d72b64294f56c394027
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3
Akademický článek
Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
Autor: Sergi Pascual-Guardia, Michelle Ataya, Isabel Ramírez-Martínez, José Yélamos, Roberto Chalela, Salomé Bellido, Miguel López-Botet, Joaquim Gea
Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, continuous exacerbations, alp
Externí odkaz: https://doaj.org/article/fe9f1938da184087970c4e68dec235ce
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4
Akademický článek
NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake.
Autor: Elisenda Alari-Pahissa, Michelle Ataya, Ilias Moraitis, Miriam Campos-Ruiz, Mireia Altadill, Aura Muntasell, Anna Moles, Miguel López-Botet
Publikováno v: PLoS Pathogens, Vol 17, Iss 8, p e1009868 (2021)
Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role played by T cells in controlling this pathogen, NK cells mediate cytotoxicity and IFNγ produc
Externí odkaz: https://doaj.org/article/37ba866f52fc4103820b1d791c8a62bf
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6
Akademický článek
Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population—Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures
Autor: Elisa Cisneros, Manuela Moraru, Natalia Gómez-Lozano, Aura Muntasell, Miguel López-Botet, Carlos Vilches
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells. KIR genes display extensive copy-number vari
Externí odkaz: https://doaj.org/article/e06a7268799144a7917e31e06f5d233c
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7
Akademický článek
Adaptive Features of Natural Killer Cells in Multiple Sclerosis
Autor: Antía Moreira, Elisenda Alari-Pahissa, Elvira Munteis, Andrea Vera, Ana Zabalza, Mireia Llop, Noelia Villarrubia, Marcel Costa-García, Roberto Álvarez-Lafuente, Luisa María Villar, Miguel López-Botet, Jose E. Martínez-Rodríguez
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile.
Externí odkaz: https://doaj.org/article/784eac7379624904b492e7adf265afe5
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8
Akademický článek
Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes
Autor: Marcel Costa-García, Michelle Ataya, Manuela Moraru, Carlos Vilches, Miguel López-Botet, Aura Muntasell
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a persistent expansion of NKG2
Externí odkaz: https://doaj.org/article/710d22039a3e42f7a9309d9c3b341d18
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