Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Miguel J Lobo"'
Autor:
Stefania Monterisi, Miguel J Lobo, Craig Livie, John C Castle, Michael Weinberger, George Baillie, Nicoletta C Surdo, Nshunge Musheshe, Alessandra Stangherlin, Eyal Gottlieb, Rory Maizels, Mario Bortolozzi, Massimo Micaroni, Manuela Zaccolo
Publikováno v:
eLife, Vol 6 (2017)
cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), localise to specific subcellular domains within which
Externí odkaz:
https://doaj.org/article/c6635f2e92ac46ac9388cee166b8faf7
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be explo
Externí odkaz:
https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f868
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/cd863df03b094f24b93fa9ac4d906638
Publikováno v:
Pharmacological Reviews
The field of cAMP signaling is witnessing exciting developments with the recognition that cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal coding. This realization has changed our understanding of cAMP sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2f30d0a9600bb5d9f53a5b6e4c38bf
http://europepmc.org/articles/PMC7770493
http://europepmc.org/articles/PMC7770493
Autor:
Gunasekaran Subramaniam, Ester Paolocci, Alexander Pfeifer, Natasha Larcom, Andreas Koschinski, Samuel Pace, He Jiang, Sara Zanivan, Manuela Zaccolo, Laia Reverte-Salisa, Frank Gesellchen, Ying-Chi Chao, Miguel J Lobo
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
Communications Biology
Communications Biology
Programmed degradation of mitochondria by mitophagy, an essential process to maintain mitochondrial homeostasis, is not completely understood. Here we uncover a regulatory process that controls mitophagy and involves the cAMP-degrading enzyme phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71629b13debf2765d0600163102792e6
http://link.springer.com/article/10.1038/s42003-020-01311-7
http://link.springer.com/article/10.1038/s42003-020-01311-7
Autor:
Roger A. Barker, Clive Wilson, Wooi F. Lim, Alfina A Speciale, Thomas C. Roberts, André Görgens, Samir El Andaloussi, Imre Mäger, Matthew J.A. Wood, Cláudia C. Mendes, Ghulam Hassan Dar, Mariana Conceição, I. Uliyakina, Wei-Li Kuan, Deborah C.I. Goberdhan, Miguel J Lobo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular communication, and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf491285a58a837b79673ed6da4152
Autor:
Verónica Felício, Ana C da Paula, Margarida D. Amaral, Carlos M. Farinha, Inna Uliyakina, Sara Afonso, Miguel J Lobo, Hugo M. Botelho
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4524, p 4524 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4524, p 4524 (2020)
Cystic Fibrosis (CF) is caused by mutations in the CF Transmembrane conductance Regulator (CFTR), the only ATP-binding cassette (ABC) transporter functioning as a channel. Unique to CFTR is a regulatory domain which includes a highly conformationally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cf9122352929d5aa64d324b43d40ac
http://europepmc.org/articles/PMC7350234
http://europepmc.org/articles/PMC7350234
Publikováno v:
Sensors, Vol 18, Iss 7, p 2164 (2018)
Sensors
Volume 18
Issue 7
Sensors (Basel, Switzerland)
Sensors, 18(7):2164. MDPI AG
Sensors
Volume 18
Issue 7
Sensors (Basel, Switzerland)
Sensors, 18(7):2164. MDPI AG
Fluorescence resonance energy transfer (FRET)-based sensors for 3&prime
&ndash
5&prime
cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) allow real-time imaging of cAMP levels and kinase activity in intact cells with hig
&ndash
5&prime
cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) allow real-time imaging of cAMP levels and kinase activity in intact cells with hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020bd07ffb07c5faf92068969c37b8e4
http://www.mdpi.com/1424-8220/18/7/2164
http://www.mdpi.com/1424-8220/18/7/2164
Autor:
Margarida D. Amaral, Miguel J Lobo, Verónica Felício, Inna Uliyakina, Carlos M. Farinha, Ana Carina Da Paula, Sara Afonso, Hugo M. Botelho
Background and Purpose: Cystic Fibrosis (CF) is caused by mutations in the CF Transmembrane conductance Regulator (CFTR), the only ABC transporter functioning as a channel. Unique to CFTR are two highly conformationally dynamic regions: the regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a446e0da0513993b34ad0f7f4197080a
https://doi.org/10.1101/320630
https://doi.org/10.1101/320630
Autor:
Miguel J Lobo, Manuela Zaccolo
Publikováno v:
Abstracts.
Parkinson’s disease (PD) is characterised by compromised mitophagy, a highly specialised quality control process that removes dysfunctional mitochondria through a macroautophagy pathway. The proteins Parkin and PINK1 are key players in the mitophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bc95a279249922e4d838dcc909e25d2
https://doi.org/10.1136/heartjnl-2018-bscr.23
https://doi.org/10.1136/heartjnl-2018-bscr.23