Výsledky vyhledávání - "Miguel García-Porras"

Akademický článek

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Autor: Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel García-Porras, Eneko Largo, Izaskun Morillo, Rubén Sánchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Félix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, José L. Nieva

Publikováno v: iScience, Vol 24, Iss 9, Pp 102987- (2021)

Summary: Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the conserved Membrane pr

Externí odkaz: https://doaj.org/article/f69c2aef00f544b7909cd6e9049a9b2c

Zobrazit plný text záznamu

Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile

Autor: José L. Nieva, Eneko Largo, Daniel P. Leaman, Michael B. Zwick, Jean-Philippe Julien, Felix Elortza, Miguel García-Porras, Edurne Rujas, Sara Insausti, Pablo Carravilla, Lei Zhang, Christian Eggeling, Hong Cui, Jose M. M. Caaveiro, Izaskun Morillo, Rubén Sánchez-Eugenia, Ibon Iloro

Publikováno v: iScience, Vol 24, Iss 9, Pp 102987-(2021)
Addi. Archivo Digital para la Docencia y la Investigación
instname
iScience

Summary Broadly neutralizing antibodies (bnAbs) against HIV-1 are frequently associated with the presence of autoreactivity/polyreactivity, a property that can limit their use as therapeutic agents. The bnAb 4E10, targeting the conserved Membrane pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1595cdb2cf49eb5fab0ddc683dce908c
https://doi.org/10.1016/j.isci.2021.102987

Zobrazit plný text záznamu

Functional Contacts between MPER and the Anti-HIV-1 Broadly Neutralizing Antibody 4E10 Extend into the Core of the Membrane

Autor: Sara Insausti, Edurne Rujas, Rubén Sánchez-Eugenia, Kouhei Tsumoto, José L. Nieva, Miguel García-Porras, Jose M. M. Caaveiro

Publikováno v: Journal of molecular biology. 429(8):1213-1226

The exceptional breadth of broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region (MPER) of the transmembrane protein gp41 makes this class of antibodies an ideal model to design HIV vaccines. From a practical point of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da840f7cb0666af3acd9b04ceedf2b5c
http://hdl.handle.net/2324/1812332

Zobrazit plný text záznamu

BFL1 Modulates Apoptosis at the Membrane Level through a Bifunctional And Multimodal Mechanism Showing Key Differences With BCLXL

Autor: Gorka Basañez, Miguel García-Porras, Ana J. García-Sáez, Hector Flores-Romero, Olatz Landeta, Begoña Ugarte-Uribe, Katia Cosentino

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Cell Death and Differentiation

BFL1 is a relatively understudied member of the BCL2 protein family which has been implicated in the pathogenesis andchemoresistance of a variety of human cancers, including hematological malignancies and solid tumours. BFL1 is generallyconsidered to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c14bd371234e29439f740a520eb3fd
http://hdl.handle.net/10810/36444

Zobrazit plný text záznamu

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments

Autor: Saul Gonzalez-Resines, Pablo Carravilla, Rubén Sánchez-Eugenia, José L. Nieva, Felix Elortza, Jean-Philippe Julien, Miguel García-Porras, Valérie Monceaux, Carmen Domene, Edurne Rujas, Sara Insausti, Asier Sáez-Cirión, Lei Zhang, Ibon Iloro, Jose M. M. Caaveiro, Daniel P. Leaman, Christian Eggeling, Michael B. Zwick, Akio Ojida

Publikováno v: Cell reports
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Cell Reports
Cell Reports, 2020, 32 (7), pp.108037. ⟨10.1016/j.celrep.2020.108037⟩

SUMMARY The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical modification of regions n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1862ebe715c0109113ae1685ad28f3ea
http://europepmc.org/articles/PMC7861656

Zobrazit plný text záznamu

Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

Autor: Miguel García-Porras, Hector Flores-Romero, Gorka Basañez

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports

Despite intensive research effort, how the paradigmatic proapoptotic protein BAX forms lethal apoptotic pores at the mitochondrial outer membrane (MOM) remains incompletely understood. Here, we used biophysical tools and minimalist model systems to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba18b3fb0a33a6ee17120ed0c603085
https://doi.org/10.1038/s41598-017-16384-4

Zobrazit plný text záznamu

Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody*

Autor: Edurne Rujas, José L. Nieva, Jose M. M. Caaveiro, Miguel García-Porras, Kouhei Tsumoto, Sara Insausti

The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure-guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of autoreactivity with memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d915b3ef4ba664e9805bbb4b79dd82e
https://europepmc.org/articles/PMC5392698/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání