Výsledky vyhledávání - "Miguel Garavís"

Akademický článek

i-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F···H and O···H hydrogen bonds

Autor: Roberto El-Khoury, Veronica Macaluso, Christopher Hennecker, Anthony K. Mittermaier, Modesto Orozco, Carlos González, Miguel Garavís, Masad J. Damha

Publikováno v: Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)

The oligonucleotide d(TC5) forms a well-characterized tetrameric i-motif in solution; however, the isolation of dimeric and trimeric intermediates remains challenging. Here, the authors report that 2′-deoxy-2′-fluoroarabinocytidine substitutions

Externí odkaz: https://doaj.org/article/4633b3ce480d4d24a7df7ba24c55d47e

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Akademický článek

Non-G Base Tetrads

Autor: Núria Escaja, Bartomeu Mir, Miguel Garavís, Carlos González

Publikováno v: Molecules, Vol 27, Iss 16, p 5287 (2022)

Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ex

Externí odkaz: https://doaj.org/article/d3c76ca9bbb5468280d0370fb4d0d8a0

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Akademický článek

NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization

Autor: Andrea Fagagnini, Miguel Garavís, Irene Gómez-Pinto, Sabrina Fasoli, Giovanni Gotte, Douglas V. Laurents

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3, p 1439 (2021)

Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. Human Angiogenin (h-ANG), a ribonuclease A family member, produces RNA fragments that regulat

Externí odkaz: https://doaj.org/article/0671f20e6b0e41619ad56c0fa19f3bd5

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Akademický článek

Detection of a G-Quadruplex as a Regulatory Element in Thymidylate synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Autor: Eva Aubets, Alex J. Félix, Miguel Garavís, Laura Reyes, Anna Aviñó, Ramón Eritja, Carlos J. Ciudad, Véronique Noé

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 14, p 5028 (2020)

Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-qua

Externí odkaz: https://doaj.org/article/8c6127fac598405cba570a91852adbe4

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NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization

Autor: Giovanni Gotte, Douglas V. Laurents, Andrea Fagagnini, Sabrina Fasoli, Irene Gómez-Pinto, Miguel Garavís

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1439, p 1439 (2021)

16 pags., 7 figs. -- This article belongs to the Special Issue Protein Oligomerization
Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2002a9534d5ebd4b7b7d020a2b1a664d
http://hdl.handle.net/10261/253435

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Detection of a G-Quadruplex as a Regulatory Element in Thymidylate Synthase for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Autor: Ramon Eritja, Anna Aviñó, Véronique Noé, Miguel Garavís, Carlos J. Ciudad, Eva Aubets, Alex J. Félix, Laura Pulido de Los Reyes

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 5028, p 5028 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Volume 21
Issue 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871a5a7249e6453bd064f0100d469cff
https://www.mdpi.com/1422-0067/21/14/5028

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Single-Stranded Condensation Stochastically Blocks G-Quadruplex Assembly in Human Telomeric RNA

Autor: Irene de Bustamante Gutiérrez, J. Ricardo Arias-Gonzalez, Carlos González, Sara de Lorenzo, Alfredo Villasante, Miguel Garavís

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia

[EN] TERRA is an RNA molecule transcribed from human subtelomeric regions toward chromosome ends potentially involved in regulation of heterochromatin stability, semiconservative replication, and telomerase inhibition, among others. TERRA contains ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901b74df1b50a0ba37be6cfc6d4f71ea
https://doi.org/10.1021/acs.jpclett.8b00722

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Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis

Autor: Carlos Fernández-Tornero, Noelia González-Polo, Jaime Alegrio Louro, Miguel Garavís, Paula Allepuz-Fuster, Olga Calvo

Publikováno v: Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname

Biogenesis ofmessenger RNA is critically influenced by the phosphorylation state of the carboxy-terminal domain (CTD) in the largest RNA polymerase II(RNAPII) subunit. Several kinases and phosphatases are required to maintain proper CTD phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c342eb57a43a8f2a5329fe3c15b42a
https://doi.org/10.1093/nar/gkw1206

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Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

Autor: Carlos González, Ruby J Roach, Miguel Garavís, Vyacheslav V. Filichev, Tracy K. Hale, Geoffrey B. Jameson

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nucleic Acids Research

12 pags., 5 figs., 1 tab.
The eukaryotic genome is functionally organized into domains of transcriptionally active euchromatin and domains of highly compact transcriptionally silent heterochromatin. Heterochromatin is constitutively assembled at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ed2d9ea6e6d245ba53d0348d036f03
http://hdl.handle.net/10261/219418

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i-Motif DNA: structural features and significance to cell biology

Autor: Masad J. Damha, Miguel Garavís, Hala Abou Assi, Carlos González

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

19 pags., 7 figs.
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220472970cb3dbad84680c800cc017ad
https://pubmed.ncbi.nlm.nih.gov/30124962

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