Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Miguel G. Toscano"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 1, Pp 14-21 (2021)
Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-c
Externí odkaz:
https://doaj.org/article/7c77607ffd914eba917339b41397b390
Autor:
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversio
Externí odkaz:
https://doaj.org/article/3d39efa050a44c909abdd4aba2f00be4
Autor:
Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated
Externí odkaz:
https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
Autor:
Miguel G. Toscano, Jeroen van der Velden, Sybrand van der Werf, Machteld Odijk, Ana Roque, Rafael J. Camacho-Garcia, Irene G. Herrera-Gomez, Irene Mancini, Peter de Haan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 124-134 (2017)
Replication-defective (RD) recombinant simian virus 40 (SV40)-based gene delivery vectors hold a great potential for clinical applications because of their presumed non-immunogenicity and capacity to induce immune tolerance to the transgene products
Externí odkaz:
https://doaj.org/article/06c68bd3b6a94f5094f1b73b60f6b041
Autor:
Miguel G. Toscano, Peter de Haan
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Viruses efficiently transfer and express their genes in host cells and evolve to evade the host’s defense responses. These properties render them highly attractive for use as gene delivery vectors in vaccines, gene, and immunotherapies. Among the v
Externí odkaz:
https://doaj.org/article/d16032fe67804711998b62aa64020570
Autor:
Miguel G. Toscano, Per Anderson, Pilar Muñoz, Gema Lucena, Marién Cobo, Karim Benabdellah, Philip D. Gregory, Michael C. Holmes, Francisco Martin
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 544-554 (2013)
SUMMARY Mutations in the WAS gene cause Wiskott-Aldrich syndrome (WAS), which is characterized by eczema, immunodeficiency and microthrombocytopenia. Although the role of WASP in lymphocytes and myeloid cells is well characterized, its role on megaka
Externí odkaz:
https://doaj.org/article/0def4f0fbcd44649a3825a6954a6dc73
Autor:
Marién Cobo, Per Anderson, Karim Benabdellah, Miguel G. Toscano, Pilar Muñoz, Angélica García-Pérez, Iván Gutierrez, Mario Delgado, Francisco Martin
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if ap
Externí odkaz:
https://doaj.org/article/044fbe41ee4e48f0a14b020ec105d849
Publikováno v:
Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5120e9196b5c50baa78eeb9751c324ee
https://doi.org/10.1080/21645515.2020.1757989
https://doi.org/10.1080/21645515.2020.1757989
Autor:
Laura Villamayor, Lorenzo Pasquali, Miguel G. Toscano, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Irene Díaz, David A. Cano, Noelia Arroyo, Rita Carmona, Anabel Rojas, Franz Martín
Publikováno v:
JCI Insight
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74191970bcb3f0c759dbeecf38831791
http://hdl.handle.net/10230/52412
http://hdl.handle.net/10230/52412
Autor:
Cristian Gonzalez-Guerrero, Fanny Lebreton, Alejandra Tamayo, Joao Anselmo, Petra I. Lorenzo, Benoit R. Gauthier, Lucrecia Herranz, Alejandro Martin-Montalvo, José Moreno, Miguel G. Toscano, Nadia Cobo-Vuilleumier, Domenico Bosco, Carmen Maria Jimenez-Moreno, Amanda Herranz, Jonathan S W R Hofsteede, Livia López-Noriega
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diabetes, Vol. 68, No 1 (2019) pp. 109-118
instname
Diabetes, Vol. 68, No 1 (2019) pp. 109-118
Transient Pax8 expression was reported in mouse islets during gestation, whereas a genome-wide linkage and admixture mapping study highlighted PAX8 as a candidate gene for diabetes mellitus (DM). We sought the significance of PAX8 expression in mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c721895dba1ec62eda41252d889c2ec
http://hdl.handle.net/10261/202559
http://hdl.handle.net/10261/202559