Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Miguel F. Brana"'
Autor:
Francesc Mitjans, Nuria Acero, Loreto Añorbe, Jaume Piulats, Gema Domínguez, Miguel F. Brana, Dolores Muñoz-Mingarro
Publikováno v:
European Journal of Medicinal Chemistry. 48:108-113
A novel series of indolocarbazoles were synthesized and their antiproliferative activity against HUVEC, LoVo, DLD-1 and ST-486 cell lines, was investigated. Those staurosporine analogs in which a substituted dimethylaminoalkoxy chain was attached to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df9f2e9ef36d27e7f118d2eb58d189a
https://doi.org/10.1016/j.ejmech.2011.11.040
https://doi.org/10.1016/j.ejmech.2011.11.040
Autor:
Carmen Martínez, Miguel F. Brana, Ismael Ortuno, Paloma Posada, Vicente Domínguez, Antonio Villarino
Publikováno v:
Journal of Heterocyclic Chemistry. 48:549-554
This article reports the reactions of salts of 4-ureylmethylpyridinium and 4-ethoxycarbonylaminomethylpyridinium with carbonylic compounds, performed with the aim of obtaining new vinylpyridinium salts. These reactions can lead to the formation of bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70390d484549c2e1526bd31816bce102
https://doi.org/10.1002/jhet.616
https://doi.org/10.1002/jhet.616
Autor:
María R. Torres, Javier Pérez-Castells, Miguel F. Brana, Beatriz de Pascual-Teresa, Marı́a Garranzo
Publikováno v:
Tetrahedron. 58:4825-4836
Starting from pyroglutamic acid, the synthesis of spiro-bis-γ-lactams, using as key step a chemoselective Michael reaction of pyroglutamates is reported. Thus, the reaction of N-BOC- l -methyl pyroglutamate with LiHMDS gives the enolates at C4 which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5a8f09d5167cbcf89e0dc25e9ebd985
https://doi.org/10.1016/s0040-4020(02)00437-4
https://doi.org/10.1016/s0040-4020(02)00437-4
Autor:
Carlos Fernandez, José M. Pérez, Miguel F. Brana, Adoración G. Quiroga, Beatriz de Pascual-Teresa, Luis Casarrubios, Gema Domínguez, Carmen Navarro-Ranninger
Publikováno v:
European Journal of Medicinal Chemistry. 37:301-313
A series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines have been prepared and their antiproliferative properties have been tested against HT-29 cell lines. Compounds 6b and 6d showed an interesting cytotoxic profile and were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59edf6e3b4bde9b6b26ebd5c4bf2985c
https://doi.org/10.1016/s0223-5234(02)01348-x
https://doi.org/10.1016/s0223-5234(02)01348-x
Publikováno v:
Journal of Heterocyclic Chemistry. 39:417-420
The synthesis and evaluation of new ligands for the H3 receptor of histamine is described. These new compounds are diimidazopyridine derivatives readily prepared by a condensation reaction of spinacine and isocyanates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48951a5b545700234d214ec0e298cb27
https://doi.org/10.1002/jhet.5570390228
https://doi.org/10.1002/jhet.5570390228
Autor:
Miguel F. Brana, S. P. Robinson, Carmen Navarro-Ranninger, Carlos Alonso, Eva I. Montero, José M. Pérez, Isabel López-Solera
Publikováno v:
Journal of Medicinal Chemistry. 42:5482-5486
The reaction of platinum salts with bis(naphthalimide), compound 1, yielded two Pt-bis(naphthalimide) complexes, compounds 2 and 3 which differ from each other in their leaving groups being 1,1-cyclobutane dicarboxylate or chloride, respectively. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb0f5374b162f7e301b8a0a7a6ca687
https://doi.org/10.1021/jm991099r
https://doi.org/10.1021/jm991099r
Autor:
Denise Perron, María Jesús Pérez de Vega, S. P. Robinson, Peter Bousquet, Miguel F. Brana, Donna Conlon
Publikováno v:
Journal of Heterocyclic Chemistry. 34:807-812
The 6-substituted benzimidazo[1,2-c]quinazoline 1 is a lead structure from our DNA intercalator program and is cytotoxic to the human colon cancer tumor line HT-29 with an inhibitory concentration 50, IC50 of 4.00 μM. In order to try and improve the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f8f244465bfa5e617b41bdae0616673
https://doi.org/10.1002/jhet.5570340316
https://doi.org/10.1002/jhet.5570340316
Autor:
Cynthia Romerdahl, Gema Domínguez, Teresa Barlozzari, Simmon Robinson, Miguel F. Brana, Beatriz Sáez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3027-3029
Dendritic imides were synthesized and evaluated as antitumor compounds. Compounds 8 and 11 showing a promising profile as inhibitors of lck but their antiproliferative activity against HT-29 was not so relevant.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587e09beb1862512449044c498aee47c
https://doi.org/10.1016/s0960-894x(01)00618-7
https://doi.org/10.1016/s0960-894x(01)00618-7
Publikováno v:
ChemInform. 33
A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2df69791adc01c68d9849bc4bb3f4c0
https://doi.org/10.1002/chin.200204145
https://doi.org/10.1002/chin.200204145
Autor:
Carlos Fernandez, Luis Casarrubios, Adoración G. Quiroga, Carmen Navarro-Ranninger, Gema Domínguez, Beatriz de Pascual-Teresa, José M. Pérez, Miguel F. Brana
Publikováno v:
ChemInform. 33
A series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines have been prepared and their antiproliferative properties have been tested against HT-29 cell lines. Compounds 6b and 6d showed an interesting cytotoxic profile and were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e2db97d322d81a56981c8328560e16
https://doi.org/10.1002/chin.200232140
https://doi.org/10.1002/chin.200232140