Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Miguel F. Braña"'
Autor:
Laurent Meijer, Olivier Lozach, Berta López, Dolores Muñoz-Mingarro, Miguel F. Braña, Mónica Cacho, Ana Ramos, M. Luisa García, F. Llinares, Beatriz de Pascual-Teresa, Nuria Acero, Elena P. Mayoral
Publikováno v:
Journal of Medicinal Chemistry. 48:6843-6854
Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp. (Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family. Analogues of the lead compound have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cf0d819c65cc1b2353554d5615eb82
https://doi.org/10.1021/jm058013g
https://doi.org/10.1021/jm058013g
Autor:
Miguel F. Braña, Cristina Abradelo, Mercedes Yuste, Mónica Cacho, Mónica Báñez-Coronel, Maria Fernanda Rey-Stolle, Ana Ramos, Jose M. Pozuelo, Mario A. García, Juan Carlos Lacal, M. Teresa Domínguez, Beatriz de Pascual-Teresa
Publikováno v:
Journal of Medicinal Chemistry. 47:1391-1399
Amonafide- and elinafide-related mono and bisintercalators, modified by the introduction of a pi-excedent furan or thiophene ring fused to the naphthalimide moiety, have been synthesized. These compounds have shown an interesting antitumor profile. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1761a0f172c89535b7ca5861b25e199e
https://doi.org/10.1021/jm0308850
https://doi.org/10.1021/jm0308850
Autor:
Miguel F. Braña, M. Luisa García, Ana Ramos, Jose M. Pozuelo, M. Teresa Domínguez, Beatriz de Pascual-Teresa, Berta López
Publikováno v:
Org. Biomol. Chem.. 2:1864-1871
A series of analogues of butyrolactone I, a natural product isolated from Aspergillus terreus that selectively inhibits the CDK2 and CDK1 kinases and that has been found to exhibit an interesting antiproliferative activity, have been synthesized. Its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76701095a78c3e8292341b10e97b46a8
https://doi.org/10.1039/b403052d
https://doi.org/10.1039/b403052d
Autor:
Christian Bailly, Mónica Cacho, Nicolas Maestre, Christelle Tardy, Miguel F. Braña, Alexandra Joubert, Carolina Carrasco
Publikováno v:
Biochemistry. 42:11751-11761
Bifunctional DNA intercalating agents have long attracted considerable attention as anticancer agents. One of the lead compounds in this category is the dimeric antitumor drug elinafide, composed of two tricyclic naphthalimide chromophores separated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e3c6a48493788f3624a162ef686204
https://doi.org/10.1021/bi034637h
https://doi.org/10.1021/bi034637h
Autor:
Miguel F. Braña
Publikováno v:
Journal of Heterocyclic Chemistry. 40:917-923
The synthesis of new ligands for the H3 histamine receptor is described. These new compounds are spinacine derivatives obtained by alkylation or Michael reaction at C6 position.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a424dd29ad4faa9e48a6595976e92de
https://doi.org/10.1002/jhet.5570400528
https://doi.org/10.1002/jhet.5570400528
Publikováno v:
Tetrahedron Letters. 39:6569-6572
Control of the chemoselectivity of reactions of pyroglutamates is determined by the nature of the nitrogen protecting group. Alkylation, aldol and Michael reactions of indole derivatives are explored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::410465587d4ecd3441d431ee3dcb9282
https://doi.org/10.1016/s0040-4039(98)01368-9
https://doi.org/10.1016/s0040-4039(98)01368-9
Autor:
X.‐D. Qian, D. Perron, Miguel F. Braña, S. P. Robinson, C. Maher, J. M. Castellano, J. George, P. F. Bousquet, D. Conlon
Publikováno v:
Journal of Medicinal Chemistry. 40:449-454
The bis-dibenz[de,h]isoquinoline-1,3-diones are a new series of antitumor agents that consist of two chromophores bridged by an alkylamino linker. In the present study we have explored the effect produced by the presence of two dibenz[de,h]isoquinoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810a6b04f6b87ad6a616ce256ab56dd4
https://doi.org/10.1021/jm960295k
https://doi.org/10.1021/jm960295k
Publikováno v:
European Journal of Biochemistry. 240:195-208
LU 79553, a bis-naphthalimide drug highly active against human solid tumour xenografts, has been shown to bis-intercalate into DNA with a helix-unwinding angle of 37 degrees. Footprinting experiments with DNase I reveal that the drug is selective for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d439a9282e12e35ddbcfd54789dbd928
https://doi.org/10.1111/j.1432-1033.1996.0195h.x
https://doi.org/10.1111/j.1432-1033.1996.0195h.x
Publikováno v:
The Journal of Organic Chemistry. 61:1369-1374
Enediyne anticancer antibiotics are a rapidly emerging class of compounds derived from natural sources. Many synthetic approaches for the construction of simpler compounds containing this pharmacophore have recently been published. Most of these appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::882eed060c68f0d8d392e8c2db32b4cb
https://doi.org/10.1021/jo951188l
https://doi.org/10.1021/jo951188l
Publikováno v:
Tetrahedron Letters. 35:8655-8658
The synthesis of model compounds 1 and 2 related to dynemicin A is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e438d0d32bb39d16a6bd7b58f1ef3d17
https://doi.org/10.1016/s0040-4039(00)78463-2
https://doi.org/10.1016/s0040-4039(00)78463-2