Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Miguel Diaz-Hernandez"'
Autor:
Beatriz Alvarez, Judit Symmank, Geraldine Zimmer-Bensch, Miguel Diaz-Hernandez, Patricia Franzka
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Graphical AbstractPTMs are crucial for biological processes contributing to healthy organ function. Protein post-translational modifications (PTMs), such as phosphorylation (P), acetylation (Ac), SUMOylation (SUMO), S-nitrosylation (Nitro), ubiquitin
Externí odkaz:
https://doaj.org/article/7436a0c37b574f57aeb398d5b128335e
Publikováno v:
Cells, Vol 11, Iss 23, p 3748 (2022)
While acute inflammation is widely accepted as an important response mechanism of cells against tissue injury, sustained inflammatory processes are increasingly recognized as one of the main contributors to numerous diseases, including central-nervou
Externí odkaz:
https://doaj.org/article/e555bb278ec64df69541ce2f527249c2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/cf5f4f249d5746cc8c437b70526a8ec4
Autor:
Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, Tobias Engel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Prolonged seizures (status epilepticus, SE) may drive hippocampal dysfunction and epileptogenesis, at least partly, through an elevation in neurogenesis, dysregulation of migration and aberrant dendritic arborization of newly-formed neurons. MicroRNA
Externí odkaz:
https://doaj.org/article/19234c54086942beaaaf52c8affce5f5
Autor:
M. Teresa Miras-Portugal, Juan I. Diaz-Hernandez, Rosa Gomez-Villafuertes, Miguel Diaz-Hernandez, Antonio R. Artalejo, Javier Gualix
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 176-181 (2015)
Amyloid precursor protein (APP) is expressed in a large variety of neural and non-neural cells. The balance between non-pathogenic and pathologic forms of APP processing, mediated by α-secretase and β-secretase respectively, remains a crucial step
Externí odkaz:
https://doaj.org/article/30d6092cc8e444649b235bdcdcfcd5f5
Autor:
Lucia Soria-Tobar, Laura Román-Valero, Álvaro Sebastián-Serrano, Paloma Aivar, Beatriz Álvarez-Castelao, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Three new drugs for AD based on monoclonal antibodies against the amyloid-β peptide (Aβ) have recently been approved because they favor the reduction of
Externí odkaz:
https://doaj.org/article/03f850d954664ef7a6519c138f55e3c5
Autor:
Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Over recent years, increasing evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of tauopathies, including Alzheimer’s disease (AD), and the ubiquitin–
Externí odkaz:
https://doaj.org/article/05e9ea4a27894273b4d32a47838b73a1
Publikováno v:
Sub-cellular biochemistry. 76
New evidences have been reported that point to the ecto-enzyme, tissue-nonspecific alkaline phosphatase (TNAP), as a key element at the origin of two opposite phenomena, neuronal differentiation and neuronal degeneration. During brain development, TN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4aac6f5484fad5c00aacba0e876a90be
https://pubmed.ncbi.nlm.nih.gov/26219721
https://pubmed.ncbi.nlm.nih.gov/26219721
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/864b8eff1fe8416e9858b0f91102a7ee
Autor:
Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L. Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernández
Publikováno v:
Neurobiology of Disease, Vol 165, Iss , Pp 105632- (2022)
Tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated Tau protein. Several studies have proposed that increased extracellular Tau (eTau) leads to the spread of cerebral tauopathy. Howev
Externí odkaz:
https://doaj.org/article/3b8bcb6c828f4b35be0d7252171b0ea4