Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Miguel Díaz-Hernández"'
Autor:
Lucia Soria-Tobar, Laura Román-Valero, Álvaro Sebastián-Serrano, Paloma Aivar, Beatriz Álvarez-Castelao, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Three new drugs for AD based on monoclonal antibodies against the amyloid-β peptide (Aβ) have recently been approved because they favor the reduction of
Externí odkaz:
https://doaj.org/article/03f850d954664ef7a6519c138f55e3c5
Autor:
Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Over recent years, increasing evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of tauopathies, including Alzheimer’s disease (AD), and the ubiquitin–
Externí odkaz:
https://doaj.org/article/05e9ea4a27894273b4d32a47838b73a1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/864b8eff1fe8416e9858b0f91102a7ee
Autor:
Álvaro Sebastián-Serrano, Jesús Merchán-Rubira, Caterina Di Lauro, Carolina Bianchi, Lucía Soria-Tobar, Sonoko Narisawa, José L. Millán, Jesús Ávila, Félix Hernández, Miguel Díaz-Hernández
Publikováno v:
Neurobiology of Disease, Vol 165, Iss , Pp 105632- (2022)
Tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated Tau protein. Several studies have proposed that increased extracellular Tau (eTau) leads to the spread of cerebral tauopathy. Howev
Externí odkaz:
https://doaj.org/article/3b8bcb6c828f4b35be0d7252171b0ea4
Autor:
Linda Francistiová, Carolina Bianchi, Caterina Di Lauro, Álvaro Sebastián-Serrano, Laura de Diego-García, Julianna Kobolák, András Dinnyés, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by a progressive cognitive decline associated with global brain damage. Initially, intracellular paired helical filaments composed by hyperphosphorylated tau and
Externí odkaz:
https://doaj.org/article/8ad1c946efc34c1e9ccc6656461de0b0
Autor:
Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have revealed that extracellular ATP,
Externí odkaz:
https://doaj.org/article/6a1944aeb4f3413ba7213ec9804a2080
Autor:
Álvaro Sebastián-Serrano, Laura de Diego-García, David C. Henshall, Tobías Engel, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Hypophosphatasia (HPP) is a rare heritable metabolic bone disease caused by hypomorphic mutations in the ALPL (in human) or Akp2 (in mouse) gene, encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme. In addition to skeletal and dental m
Externí odkaz:
https://doaj.org/article/a912931503f949ce9f9342273387f977
Autor:
Álvaro Sebastián-Serrano, Laura de Diego-García, Carlos Martínez-Frailes, Jesús Ávila, Herbert Zimmermann, José Luis Millán, María Teresa Miras-Portugal, Miguel Díaz-Hernández
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 95-100 (2015)
Tissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in n
Externí odkaz:
https://doaj.org/article/86722c46bd7a427e88aed7eb196d3292
Autor:
Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 3, Pp 461-469 (2009)
Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to excitot
Externí odkaz:
https://doaj.org/article/ecc481ee56a54ab2a61ee8872810af8f
Autor:
Juan Ignacio Díaz-Hernández, Álvaro Sebastián-Serrano, Rosa Gómez-Villafuertes, Miguel Díaz-Hernández, María Teresa Miras-Portugal
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123121 (2015)
P2X receptors are ligand-gated ion channels sensitive to extracellular nucleotides formed by the assembling of three equal or different P2X subunits. In this work we report, for the first time, the accumulation of the P2X6 subunit inside the nucleus
Externí odkaz:
https://doaj.org/article/266efbec28434adbaea60ce3460f863d