Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Miguel Carmena‐Bargueño"'
Autor:
Aiora Cenigaonandia‐Campillo, Ana Garcia‐Bautista, Anxo Rio‐Vilariño, Arancha Cebrian, Laura delPuerto, José Antonio Pellicer, José Antonio Gabaldón, Horacio Pérez‐Sánchez, Miguel Carmena‐Bargueño, Carolina Meroño, Javier Traba, María Jesús Fernandez‐Aceñero, Natalia Baños‐Herraiz, Lorena Mozas‐Vivar, Estrella Núñez‐Delicado, Jesús Garcia‐Foncillas, Óscar Aguilera
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2212-2233 (2024)
In pancreatic ductal adenocarcinoma (PDAC), metabolic rewiring and resistance to standard therapy are closely associated. PDAC cells show enormous requirements for glucose‐derived citrate, the first rate‐limiting metabolite in the synthesis of ne
Externí odkaz:
https://doaj.org/article/15680545600940349d1f3088fd3a5d0b
Autor:
Redouane Rebai, Miguel Carmena-Bargueño, Mohammed Esseddik Toumi, Imene Derardja, Luc Jasmin, Horacio Pérez-Sánchez, Abdennacer Boudah
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30287- (2024)
Existing inhibitors of kynurenine-3-monooxygenase (KMO) have side effects and poorly cross the blood-brain barrier. Therefore, the discovery of new molecules targeting KMO isnecessary.This study aims to develop a novel therapeutic drug targeting KMO
Externí odkaz:
https://doaj.org/article/9937d0ecb5f84509abc5f26a468b9703
Autor:
Pedro Garrido-Rodríguez, Miguel Carmena-Bargueño, María Eugenia de la Morena-Barrio, Carlos Bravo-Pérez, Belén de la Morena-Barrio, Rosa Cifuentes-Riquelme, María Luisa Lozano, Horacio Pérez-Sánchez, Javier Corral
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0304451 (2024)
Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to inactive forms. Unfortunately, conformational conseq
Externí odkaz:
https://doaj.org/article/8c903214e7494b25930f3e8d5745ede3
Autor:
Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 9, Iss , Pp 100110- (2023)
Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme. Derivatization of the DCQ moiety improved th
Externí odkaz:
https://doaj.org/article/260796f6cd1e40078b733e1f62ca1d07
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1669 (2023)
Caffeoylquinic (5-CQA) and feruloylquinic (5-FQA) acids, found in coffee and other plant sources, are known to exhibit diverse biological activities, including potential antioxidant effects. However, the underlying mechanisms of these phenolic compou
Externí odkaz:
https://doaj.org/article/d9c6924f6c5547abb08c37a29260557b
Autor:
Joanna Grzelczyk, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Joanna Oracz, Grażyna Budryn
Publikováno v:
Molecules, Vol 28, Iss 16, p 5996 (2023)
Type II topoisomerase (TOPII) is an enzyme that influences the topology of DNA. DNA breaks generated by TOPII may result in mutagenic or cytotoxic changes in cancer cells. In this study, we characterized interactions of TOPIIα with coffee extracts a
Externí odkaz:
https://doaj.org/article/d011b59d74cc4c7c939d5cf120b7d671
Autor:
Marjorie Laurence Barrier, Iwona Teresa Myszor, Priyanka Sahariah, Snaevar Sigurdsson, Miguel Carmena-Bargueño, Horacio Pérez-Sánchez, Gudmundur Hrafn Gudmundsson
Publikováno v:
Molecular Immunology. 155:153-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ecaa867b3faa747047650d583d77f3
https://doi.org/10.1016/j.molimm.2023.02.003
https://doi.org/10.1016/j.molimm.2023.02.003
Autor:
Alejandro Rodríguez-Martínez, Jochem Nelen, Miguel Carmena-Bargueño, Carlos Martínez-Cortés, Irene Luque, Horacio Pérez-Sánchez
One of the most featured techniques to analyze the physical movement of molecules is Molecular Dynamics (MD) simulations. Among the different programs used to perform them, GROMACS is one of the most widely used open-source packages. We present ASGAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c54dafdb5483aa2e4e533b6b5743d51
https://zenodo.org/record/7774080
https://zenodo.org/record/7774080
Autor:
Pedro Garrido-Rodríguez, Miguel Carmena-Bargueño, María Eugenia de la Morena-Barrio, Carlos Bravo-Pérez, Belén de la Morena-Barrio, Rosa Cifuentes-Riquelme, María Luisa Lozano, Horacio Pérez-Sánchez, Javier Corral
Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to inactive forms. Unfortunately, conformational conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a16d73c4a0498285f1de579773767246
https://doi.org/10.1101/2023.01.31.526415
https://doi.org/10.1101/2023.01.31.526415
Autor:
Silvia Montoro-García, Sara Martínez-Sánchez, Miguel Carmena-Bargueño, Horacio Pérez-Sánchez, María Campillo, Camille Oger, Jean-Marie Galano, Thierry Durand, Ángel Gil-Izquierdo, José Antonio Gabaldón
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2730
Volume 24
Issue 3
Pages: 2730
Plant phytoprostanes (PhytoPs) are lipid oxidative stress mediators that share structural similarities with mammal prostaglandins (PGs). They have been demonstrated to modulate inflammatory processes mediated by prostaglandins. The present study aims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6f36832c6dd411ecb93d3c02d0c6ae