Výsledky vyhledávání - "Miguel A. Zinny"

Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects

Autor: David Hreniuk, Arthur J. Bergman, Marcella Ruddy, Miguel A. Zinny, Gary A. Herman, Goutam C. Mistry, Wei Zheng, Keith Gottesdiener, John A. Wagner

Publikováno v: British Journal of Clinical Pharmacology. 66:36-42

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • No data are available on the potential drug interaction of sitagliptin and glyburide. • Sitagliptin belongs to a new class of drugs called DPP-4 inhibitors recently approved for the treatment of Type 2 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626a380f1f8ff1615906b1fb36103996
https://doi.org/10.1111/j.1365-2125.2008.03148.x

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Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450-3A Activity: Comparison With Grapefruit Juice

Autor: Jerold S. Harmatz, Yanli Zhao, Lauren E. Oleson, Miguel A. Zinny, Michael H. Court, Dora Farkas, David J. Greenblatt

Publikováno v: The Journal of Clinical Pharmacology. 47:286-294

The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7ccffa145207f277d1ee73373ac3ac
https://doi.org/10.1177/0091270006298359

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A dose-response study of the efficacy and safety of ipratropium bromide nasal spray in the treatment of the common cold

Autor: David C. Korts, Paul Koker, Louis Diamond, Martin Posner, James C. Kisicki, Miguel A. Zinny, Dockhorn Rj, J Grossman, Margaret T. Wecker

Publikováno v: Journal of Allergy and Clinical Immunology. 95:1139-1146

Rhinorrhea is an annoying symptom of the common cold for which effective therapy is not currently available. Ipratropium bromide (IB) is an anticholinergic drug that has been shown to decrease glandular secretion when applied topically to the nasal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3306eb6db2b8110521dcf0194855a5c3
https://doi.org/10.1016/s0091-6749(95)70219-9

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Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase

Autor: Michael H. Court, Jerold S. Harmatz, Noah Berkowitz, Diane E. Peters, Malcolm W. MacNab, Lauren E. Oleson, Miguel A. Zinny, David J. Greenblatt

Publikováno v: British journal of clinical pharmacology. 68(6)

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The viral protease inhibitor ritonavir is known to inhibit clearance of intravenous midazolam. • ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238826cd70f065cc7996dfc26445dca2
https://pubmed.ncbi.nlm.nih.gov/20002087

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Bioavailability and pharmacokinetics of oral ofloxacin formulations in normal subjects

Autor: Marc LeBel, Miguel A. Zinny, Soledad C. Flor, Gary E. Stein

Publikováno v: Current Medical Research and Opinion. 12:479-484

The relative bioavailability and pharmacokinetics of ofloxacin tablets and a reference oral solution of ofloxacin were compared in 32 normal male subjects using a randomized two-way crossover design. After an overnight fast, subjects were randomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf7b3cb126a6d490845cb64a186d3b4
https://doi.org/10.1185/03007999109111658

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Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers

Autor: Selene Leon, Yan-Ling He, Venkateswar Jarugula, Brian Flannery, Joelle Campestrini, Monica Ligueros-Saylan, Miguel A. Zinny

Publikováno v: Current medical research and opinion. 24(6)

Vildagliptin is an orally active, potent and selective DPP-4 inhibitor that improves glycemic control in patients with type 2 diabetes by increasing alpha- and beta-cell responsiveness to glucose.This open-label, single-center, randomized, two-period

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b8a93cc8e8198ded5ec4aead40add1
https://pubmed.ncbi.nlm.nih.gov/18471347

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Multicenter Evaluation of the Hemodynamic Effects of Bisoprolol in Patients with Mild to Moderate Hypertension

Autor: Albert A. Carr, B McKee, M Desnoyers, Miguel A. Zinny, D M O'Donnell, B R Nelson, L M Prisant, R J Westcott, Brian S. Bryzinski

Publikováno v: The Journal of Clinical Pharmacology. 30:1096-1101

Twenty-six patients with mild-to-moderate essential hypertension participated in a 6-week outpatient, multicenter, randomized, double-blind, placebo-controlled two-way crossover study to assess the hemodynamic effects of bisoprolol (20 mg QD) at stea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8185a36e2301987f3cb536812ecc9926
https://doi.org/10.1002/j.1552-4604.1990.tb01851.x

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Clonazepam pharmacokinetics: comparison of subcutaneous microsphere injection with multiple-dose oral administration

Autor: E. S. Nuwayser, Phillip Blaskovich, Miguel A. Zinny, Gengsheng Chen, David J. Greenblatt, Jerold S. Harmatz

Publikováno v: Journal of clinical pharmacology. 45(11)

Nine healthy volunteers participated in a 3-phase clinical pharmacokinetic study of the benzodiazepine derivative clonazepam. During phases I and II, subjects received the conventional oral dosage form of clonazepam, 0.5 mg 3 times daily, for 7 days.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f1d6144834a3b08bb1fde2aae2c21
https://pubmed.ncbi.nlm.nih.gov/16239362

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Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies

Autor: Yan Luo, Elke S Perloff, Jerold S. Harmatz, Lisa L. von Moltke, Miguel A. Zinny, David J. Greenblatt

Publikováno v: Clinical pharmacology and therapeutics. 79(1)

Objectives Recent anecdotal, unvalidated case reports have suggested potentiation of warfarin-induced anticoagulation by cranberry juice, possibly through inhibition of human cytochrome P450 (CYP) 2C9, the enzyme responsible for the clearance of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b7ccccb631aea62343d3dc8cfcdab8
https://pubmed.ncbi.nlm.nih.gov/16413247

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Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

Autor: David J. Greenblatt, Gengsheng Chen, Miguel A. Zinny, Lisa L. von Moltke, Barbara W. LeDuc, James L. Weemhoff, Jerold S. Harmatz, Charles J. Kelley, Cheng Jen

Publikováno v: Clinical pharmacology and therapeutics. 74(2)

Background Components of grapefruit juice may impair the activity of intestinal cytochrome P450 (CYP) 3A enzymes, sometimes resulting in clinically important drug interactions. The time course of recovery from CYP3A inhibition after a single exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdec902431ffbe1fe832c9553c69850
https://pubmed.ncbi.nlm.nih.gov/12891222

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