Výsledky vyhledávání - "Miguel A. Zaballos"

Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer

Autor: Miguel A. Zaballos, Adrián Acuña-Ruiz, Marta Morante, Garcilaso Riesco-Eizaguirre, Piero Crespo, Pilar Santisteban

Publikováno v: Cellular and Molecular Life Sciences. 79

Background: RAS-to-ERK signaling is crucial for the onset and progression of advanced thyroid carcinoma, and blocking ERK dimerization provides a therapeutic benefit in several human carcinomas. Here we analyzed the effects of DEL-22379, a relatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77b9ac653363764ab7db7102ddb005c
https://doi.org/10.1007/s00018-022-04530-9

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Akademický článek

The TALE transcription factor homothorax functions to assemble heterochromatin during Drosophila embryogenesis.

Autor: Miguel Angel Zaballos, Walter Cantero, Natalia Azpiazu

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120662 (2015)

We have previously identified Homothorax (Hth) as an important factor for the correct assembly of the pericentromeric heterochromatin during the first fast syncytial divisions of the Drosophila embryo. Here we have extended our studies to later stage

Externí odkaz: https://doaj.org/article/31af627a982e45cf90f3b1130991b853

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TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome

Autor: Lucía Garzón, Carmen Luna, Christian M. Moya, Elena Gallego, José Moreno, Rogelio Simón, Pilar Santisteban, Miguel A. Zaballos, Michael B. Yaffe

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[Context]: Identification of a frameshift heterozygous mutation in the transcription factor NKX2-1 in a patient with brain-lung-thyroid syndrome (BLTS) and life-threatening lung emphysema.
[Objective]: To study the genetic defect that causes thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea345f5f867dd64c64bf27d25d321a0d
https://doi.org/10.1210/jc.2017-01241

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Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer

Autor: Piero Crespo, Pilar Santisteban, Miguel A. Zaballos, Adrián Acuña-Ruiz, Marta Morante

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Thyroid cancer is mostly an ERK-driven carcinoma, as up to 70% of thyroid carcinomas are caused by mutations that activate the RAS/ERK mitogenic signaling pathway. The incidence of thyroid cancer has been steadily increasing for the last four decades

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d3140c4a144a547db1548215522612
http://hdl.handle.net/10261/204543

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Key signaling pathways in thyroid cancer

Autor: Miguel A. Zaballos, Pilar Santisteban

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Whole genome sequencing approaches have provided unprecedented insights into the genetic lesions responsible for the onset, progression and dedifferentiation of various types of thyroid carcinomas. Through these efforts, the MAPK and PI3K signaling c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a33e24779379321d3790fa1142e883e
http://hdl.handle.net/10261/187869

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β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation

Autor: Garcilaso Riesco-Eizaguirre, Ana Sastre-Perona, Pilar Santisteban, Miguel A. Zaballos

Publikováno v: Oncotarget
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
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Mutations in β-catenin are traditionally described as late events in thyroid cancer progression. However, the functional implications of β-catenin dysregulation in the context of tumor initiating events remain unclear. The aim of this work was to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd6f208f3c941793122e6dc48248c58
https://pubmed.ncbi.nlm.nih.gov/27384483

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FOXO1 controls thyroid cell proliferation in response to TSH and IGF-I and is involved in thyroid tumorigenesis

Autor: Pilar Santisteban, Miguel A. Zaballos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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TSH and insulin/IGF-I synergistically induce the proliferation of thyroid cells mainly through the cAMP and phosphatidylinositol 3-kinase (PI3K) pathways. However, the events involved in this cooperative induction remain unknown, and molecules that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f2804bdd22e8fcb4872ee2c0ad49a1
http://hdl.handle.net/10261/76937

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DARPP-32 is required for MAPK/ERK signaling in thyroid cells

Autor: Ana Chocarro-Calvo, Pilar Santisteban, Custodia García-Jiménez, Miguel A. Zaballos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Modulation of MAPK signaling duration by cAMP defines its physiological output by driving cells toward proliferation or differentiation. Understanding how the kinetics of MAPK signaling are integrated with other cellular signals is a key issue in dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b23af667c1a0af75429e6a8bedd183e
http://hdl.handle.net/10261/76669

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Gβγ dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells

Autor: Bibian García, Miguel A. Zaballos, Pilar Santisteban

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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18 pages, 10 figures.
Signaling by TSH through its receptor leads to the dissociation of trimeric G proteins into Galpha and Gbetagamma. Galphas activates adenylyl cyclase, which increases cAMP levels that induce several effects in the thyroid c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef001b38050db483415b6b54c3b2dc06
http://hdl.handle.net/10261/24888

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The TALE Transcription Factor Homothorax Functions to Assemble Heterochromatin during Drosophila Embryogenesis

Autor: Walter Cantero, Natalia Azpiazu, Miguel A. Zaballos

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120662 (2015)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d50cc641e25c1bf124eab17a117db5
https://doi.org/10.1371/journal.pone.0120662

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