Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Miguel A. Tam"'
Autor:
Yan Li, Roberto Tinoco, Lisa Elmén, Igor Segota, Yibo Xian, Yu Fujita, Avinash Sahu, Raphy Zarecki, Kerrie Marie, Yongmei Feng, Ali Khateb, Dennie T. Frederick, Shiri K. Ashkenazi, Hyungsoo Kim, Eva Guijarro Perez, Chi-Ping Day, Rafael S. Segura Muñoz, Robert Schmaltz, Shibu Yooseph, Miguel A. Tam, Tongwu Zhang, Emily Avitan-Hersh, Lihi Tzur, Shoshana Roizman, Ilanit Boyango, Gil Bar-Sela, Amir Orian, Randal J. Kaufman, Marcus Bosenberg, Colin R. Goding, Bas Baaten, Mitchell P. Levesque, Reinhard Dummer, Kevin Brown, Glenn Merlino, Eytan Ruppin, Keith Flaherty, Amanda Ramer-Tait, Tao Long, Scott N. Peterson, Linda M. Bradley, Ze’ev A. Ronai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.
Externí odkaz:
https://doaj.org/article/47e63127b17f4776963dab1e5a8faa8f
Autor:
Yu Fujita, Ali Khateb, Yan Li, Roberto Tinoco, Tongwu Zhang, Haggai Bar-Yoseph, Miguel A. Tam, Yehuda Chowers, Edmond Sabo, Shiran Gerassy-Vainberg, Elina Starosvetsky, Brian James, Kevin Brown, Shai S. Shen-Orr, Linda M. Bradley, Philippe A. Tessier, Ze’ev A. Ronai
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3296-3311.e6 (2018)
Summary: Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, whi
Externí odkaz:
https://doaj.org/article/47d96a8a488349d4a35be97b7725e1e4
Autor:
Ulf Alexander Wenzel, Maria eFernandez-Santoscoy, Miguel A. Tam, Pia eTegtmeyer, Mary Jo eWick
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Previous studies using purified TLR ligands plus agonistic anti-CD40 antibodies showed that TLRs and CD40 can act synergistically on dendritic cells (DCs) to optimize T cell activation and Th1 differentiation. However, a synergistic effect of TLRs an
Externí odkaz:
https://doaj.org/article/2716e035e78b4b2d93e64f5f8fa6a10d
Autor:
Lisa Elmén, Dennie T. Frederick, Yibo Xian, Bas J. G. Baaten, Yan Li, Amir Orian, Hyungsoo Kim, Robert Schmaltz, Kevin M. Brown, Glenn Merlino, Roberto Tinoco, Eytan Ruppin, Ali Khateb, Ilanit Boyango, Avinash Das Sahu, Eva Guijarro Perez, Yongmei Feng, Randal J. Kaufman, Chi-Ping Day, Ze'ev Ronai, Tao Long, Lihi Tzur, Gil Bar-Sela, Emily Avitan-Hersh, Marcus Bosenberg, Shiri K. Ashkenazi, Mitchell P. Levesque, Shoshana Roizman, Linda M. Bradley, Raphy Zarecki, Yu Fujita, Scott N. Peterson, Colin R. Goding, Kerrie L. Marie, Reinhard Dummer, Rafael S. Segura Muñoz, Shibu Yooseph, Keith T. Flaherty, Tongwu Zhang, Amanda E. Ramer-Tait, Igor Segota, Miguel A. Tam
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Li, Y, Tinoco, R, Elmén, L, Segota, I, Xian, Y, Fujita, Y, Sahu, A, Zarecki, R, Marie, K L, Feng, Y, Khateb, A, Frederick, D T, Ashkenazi, S K, Kim, H, Pérez-Guijarro, E, Day, C-P, Segura Muñoz, R S, Schmaltz, R, Yooseph, S, Tam, M A, Zhang, T, Avitan-Hersh, E, Tzur, L, Roizman, S, Boyango, I, Bar-Sela, G, Orian, A, Kaufman, R J, Bosenberg, M, Goding, C R, Baaten, B, Levesque, M P, Dummer, R, Brown, K M, Merlino, G, Ruppin, E, Flaherty, K T, Ramer-Tait, A, Long, T, Peterson, S N, Bradley, L M & Ronai, Z A 2019, ' Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice ', Nature Communications, vol. 10, 1492, pp. 1-16 . https://doi.org/10.1038/s41467-019-09525-y
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Li, Y, Tinoco, R, Elmén, L, Segota, I, Xian, Y, Fujita, Y, Sahu, A, Zarecki, R, Marie, K L, Feng, Y, Khateb, A, Frederick, D T, Ashkenazi, S K, Kim, H, Pérez-Guijarro, E, Day, C-P, Segura Muñoz, R S, Schmaltz, R, Yooseph, S, Tam, M A, Zhang, T, Avitan-Hersh, E, Tzur, L, Roizman, S, Boyango, I, Bar-Sela, G, Orian, A, Kaufman, R J, Bosenberg, M, Goding, C R, Baaten, B, Levesque, M P, Dummer, R, Brown, K M, Merlino, G, Ruppin, E, Flaherty, K T, Ramer-Tait, A, Long, T, Peterson, S N, Bradley, L M & Ronai, Z A 2019, ' Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice ', Nature Communications, vol. 10, 1492, pp. 1-16 . https://doi.org/10.1038/s41467-019-09525-y
Nature Communications
Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034278988dcad7bc3424498560983469
https://doi.org/10.1038/s41467-019-09525-y
https://doi.org/10.1038/s41467-019-09525-y
Autor:
Brian P. James, Kevin K. Brown, Tongwu Zhang, Philippe A. Tessier, Edmond Sabo, Haggai Bar-Yoseph, Yehuda Chowers, Linda M. Bradley, Shiran Gerassy-Vainberg, Ali Khateb, Yu Fujita, Elina Starosvetsky, Shai S. Shen-Orr, Yan Li, Roberto Tinoco, Ze'ev Ronai, Miguel A. Tam
Publikováno v:
Fujita, Yu; Khateb, Ali; Li, Yan; Tinoco, Roberto; Zhang, Tongwu; Bar-Yoseph, Haggai; et al.(2018). Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis.. Cell reports, 24(12), 3296-3311.e6. doi: 10.1016/j.celrep.2018.08.057. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8243r5fk
Cell Reports, Vol 24, Iss 12, Pp 3296-3311.e6 (2018)
Cell reports
Cell Reports, Vol 24, Iss 12, Pp 3296-3311.e6 (2018)
Cell reports
SUMMARY Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b0deaf6cf4a8f244460125cbb436a9
http://www.escholarship.org/uc/item/8243r5fk
http://www.escholarship.org/uc/item/8243r5fk
Publikováno v:
Immunology Letters. 138:104-112
Plasmacytoid dendritic cells (pDCs) are a subpopulation of dendritic cells specialized in the production of IFN-α/β, particularly during viral infections. In this way pDCs directly impact antiviral immunity and influence T cell activation. However,
Autor:
Miguel A. Tam, Mary Jo Wick
Publikováno v:
Immunology. 128:429-438
Signalling pathways mediated by MyD88 are important for sensing Toll-like receptor (TLR) ligands and directing an immune response. However, the influence of MyD88-derived cytokines and interferon (IFN)-alpha/beta, the latter being made by both MyD88-
Publikováno v:
Immunological Reviews. 225:140-162
Dendritic cells (DCs), monocytes, macrophages, and neutrophils are myeloid-derived phagocytes critical to controlling bacterial infections, and these cells have complementary functions to ensure host survival. Recent data have shed light on the dynam
Publikováno v:
Cellular Microbiology. 10:1517-1529
The interface between dendritic cells (DCs) and T cells is critical to elicit effective immunity against pathogens. The maturation state of DCs determines the quality of the interaction and governs the type of response. DCs can be matured directly th
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology
Frontiers in Immunology
Previous studies using purified toll-like receptor (TLR) ligands plus agonistic anti-CD40 antibodies showed that TLRs and CD40 can act synergistically on dendritic cells (DCs) to optimize T cell activation and Th1 differentiation. However, a synergis