Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Miguel A. Rodriguez Santos"'
Autor:
Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purifi
Externí odkaz:
https://doaj.org/article/baaab0297501451c838881430fb7712c
Autor:
Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 670-681.e8 (2019)
Summary: The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and
Externí odkaz:
https://doaj.org/article/21aef49f490e40c29d479eb0c499b258
Autor:
Nicholas J. Brandon, Georgina Kontou, Paul Davies, Joshua L. Smalley, David Albrecht, Miguel A. Rodriguez Santos, Tarek Z. Deeb, Stephen J. Moss, Krithika Abiraman, Catherine Choi, Qiu Ren, Christopher E. Bope
KCC2 plays a critical role in determining the efficacy of synaptic inhibition and deficits in its activity lead to epilepsy and neurodevelopmental delay. Here we use unbiased proteomic analyses to demonstrate that KCC2 forms stable protein complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45867b0170f1a2dfd9ed2aca472d6d00
Autor:
Shu Fun Josephine Ng, Jack H. Howden, Christopher E. Bope, Miguel A. Rodriguez Santos, Jake S. Dengler, Matt R. Kelley, Qiu Ren, Paul Davies, Ross A. Cardarelli, Catherine Choi, Josef T. Kittler, Joshua L. Smalley, Stephen J. Moss, Georgina Kontou, Nicholas J. Brandon
Publikováno v:
The Journal of Biological Chemistry
The K+/Cl− cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl− levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABAARs). In acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99424a7f43e3b1d015f02bb407fe0519
https://doi.org/10.1016/j.jbc.2021.100364
https://doi.org/10.1016/j.jbc.2021.100364
Autor:
Peter M. Andrews, Miguel A. Rodriguez Santos, Paul Davies, Nicholas J. Brandon, Thomas A. Ollerhead, Heike J. Wobst, Rochelle M. Hines, Yvonne E. Moore, Joshua L. Smalley, Stephen J. Moss, Anna J. Nathanson, Yihui Zhang
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 3, Pp 670-681.e8 (2019)
Cell Reports, Vol 28, Iss 3, Pp 670-681.e8 (2019)
SUMMARY The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1–3), β(1–3), and γ2 subunits,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63a429c6d04fd3fe655ab0885b962c8
http://europepmc.org/articles/PMC8283774
http://europepmc.org/articles/PMC8283774