Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci

Autor: Pedro A. Jurado-Camacho, Miguel A. Cid-Soto, Francisco Barajas-Olmos, Humberto García-Ortíz, Paulina Baca-Peynado, Angélica Martínez-Hernández, Federico Centeno-Cruz, Cecilia Contreras-Cubas, María Elena González-Villalpando, Yolanda Saldaña-Álvarez, Guadalupe Salas-Martinez, Elvia C. Mendoza-Caamal, Clicerio González-Villalpando, Emilio J. Córdova, Lorena Orozco

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Background: Plasma lipid levels are a major risk factor for cardiovascular diseases. Although international efforts have identified a group of loci associated with the risk of dyslipidemia, Latin American populations have been underrepresented in the

Externí odkaz: https://doaj.org/article/5efc45f5b83844a3949a94514f5f0895

Exploring the Th2 Response in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Potential Modulator of the Renin-Angiotensin System (RAS) Pathway in Hypertension Development

Autor: Lucía Angélica Méndez-García, Galileo Escobedo, Itzel Baltazar-Pérez, Nydia Angélica Ocampo-Aguilera, José Alfonso Arreola-Miranda, Miguel Angel Cid-Soto, Ana Alfaro-Cruz, Antonio González-Chávez, Aquiles Ranferi Ocaña-Guzmán, Helena Solleiro-Villavicencio

Publikováno v: Life, Vol 14, Iss 9, p 1080 (2024)

Non-alcoholic fatty liver disease (NAFLD), now referred to as metabolic dysfunction-associated steatotic liver disease (MASLD), is alarmingly increasing alongside the cases of obesity worldwide. MASLD is an underestimated metabolic abnormality closel

Externí odkaz: https://doaj.org/article/f483586036d24b73a03373c76f02626c

Low Serum Interleukin-6 Is a Differential Marker of Obesity-Related Metabolic Dysfunction in Women and Men

Autor: Sergio Islas-Andrade, Miguel Carrero-Aguirre, Lucia A Méndez-García, Alfonso Olivos-García, Galileo Escobedo, Miguel Ángel Cid-Soto, José Manuel Fragoso, Fernanda Trejo-Millán, José A Aguayo-Guerrero

Publikováno v: Journal of Interferon & Cytokine Research. 40:131-138

There is scant information regarding the role of interleukin (IL)-6 in obesity-related metabolic dysfunction in humans. Thus, we studied the serum levels of IL-6 in normal weight, overweight, and obese subjects, and examined associations of IL-6 with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5776dd9498940bf855a6062b84e92b1a
https://doi.org/10.1089/jir.2019.0149

The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas

Autor: Angélica Martínez-Hernández, Guadalupe Salas-Martínez, Eva Gabriela Salas-Bautista, Elaheh Mirzaeicheshmeh, Francisco Loeza-Becerra, Aleksandar Kostic, Augusto Rojas-Martinez, Carlos Galaviz-Hernández, Blanca Patricia Lazalde-Ramos, Austin W. Reynolds, Paulina Baca, José Sánchez-Corona, Humberto García-Ortiz, Antonio Blanchet, Héctor Rangel-Villalobos, Jazmín Ramos-Madrigal, José Concepción Jiménez-López, Elvia Mendoza-Caamal, Silvia Esperanza Flores-Martínez, Rafael Velázquez-Cruz, Juan Luis Jiménez-Ruíz, Marlen Flores-Huacuja, Guadalupe León-Reyes, Federico Centeno-Cruz, María Del Carmen Abrahantes-Pérez, Mirna Edith Morales-Marín, Lorena Orozco, Rocio Ortiz-Lopez, Emilio J. Cordova, Miguel Ángel Cid-Soto, Raúl Mojica-Espinosa, Yolanda Saldaña-Alvarez, Deborah A. Bolnick, Francisco Barajas-Olmos, Martha Sosa-Macías, Meradeth Snow, Cecilia Contreras-Cubas, Alejandra Guadalupe García-Zapién, Isabel Cicerón-Arellano, Federico Sánchez-Quinto

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
García-Ortiz, H, Barajas-Olmos, F, Contreras-Cubas, C, Cid-Soto, M Á, Córdova, E J, Centeno-Cruz, F, Mendoza-Caamal, E, Cicerón-Arellano, I, Flores-Huacuja, M, Baca, P, Bolnick, D A, Snow, M, Flores-Martínez, S E, Ortiz-Lopez, R, Reynolds, A W, Blanchet, A, Morales-Marín, M, Velázquez-Cruz, R, Kostic, A D, Galaviz-Hernández, C, García-Zapién, A G, Jiménez-López, J C, León-Reyes, G, Salas-Bautista, E G, Lazalde-Ramos, B P, Jiménez-Ruíz, J L, Salas-Martínez, G, Ramos-Madrigal, J, Mirzaeicheshmeh, E, Saldaña-Alvarez, Y, del Carmen Abrahantes-Pérez, M, Loeza-Becerra, F, Mojica-Espinosa, R, Sánchez-Quinto, F, Rangel-Villalobos, H, Sosa-Macías, M, Sánchez-Corona, J, Rojas-Martinez, A, Martínez-Hernández, A & Orozco, L 2021, ' The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas ', Nature Communications, vol. 12, 5942 . https://doi.org/10.1038/s41467-021-26188-w
Nature Communications

The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7c2adc40a7213887db87fb982e3a6b
https://doi.org/10.1038/s41467-021-26188-w

Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population

Autor: Hermenegildo Vicenteño-Ayala, Cecilia Contreras-Cubas, Humberto García-Ortiz, Juan Luis Jiménez-Ruíz, Francisco Barajas-Olmos, Elvia Mendoza-Caamal, Yolanda Saldaña-Alvarez, María Guadalupe Salas-Martínez, Diana Karen Mendiola-Soto, Miguel Ángel Cid-Soto, Angélica Martínez-Hernández, Federico Centeno-Cruz, Lorena Orozco, Emilio J. Cordova, Angélica Luckie-Duque, Elaheh Mirzaeicheshmeh

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0225030 (2019)
PLoS ONE

The Mexican population is characterized by high and particular admixture, and the picture of variants associated with disease remains unclear. Here we investigated the distribution of single nucleotide polymorphisms (SNPs) in the Mexican population.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f754bd1410938ae9649949039de91600
https://doaj.org/article/4f75838e8d5846c7ba62560e9445166e