Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Autor: Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-14 (2019)

Abstract Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer’s disease (AD). Soluble TREM2 (sTREM2) resu

Externí odkaz: https://doaj.org/article/ab7d5e6c46924031bfbabba05580f8a4

The left frontal cortex supports reserve in aging by enhancing functional network efficiency

Autor: Nicolai Franzmeier, Julia Hartmann, Alexander N. W. Taylor, Miguel Á. Araque-Caballero, Lee Simon-Vermot, Lana Kambeitz-Ilankovic, Katharina Bürger, Cihan Catak, Daniel Janowitz, Claudia Müller, Birgit Ertl-Wagner, Robert Stahl, Martin Dichgans, Marco Duering, Michael Ewers

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)

Abstract Background Recent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that global connectivity of

Externí odkaz: https://doaj.org/article/7ec3296c9d4647579eebcabe60f5f089

Correspondence Between Resting-State and Episodic Memory-Task Related Networks in Elderly Subjects

Autor: Lee Simon-Vermot, Alexander N. W. Taylor, Miguel À. Araque Caballero, Nicolai Franzmeier, Katharina Buerger, Cihan Catak, Daniel Janowitz, Lana M. Kambeitz-Ilankovic, Birgit Ertl-Wagner, Marco Duering, Michael Ewers

Publikováno v: Frontiers in Aging Neuroscience, Vol 10 (2018)

Resting-state fMRI studies demonstrated temporally synchronous fluctuations in brain activity among ensembles of brain regions, suggesting the existence of intrinsic functional networks. A spatial match between some of the resting-state networks and

Externí odkaz: https://doaj.org/article/82ed337cb6b247ca8d029216378f81d6

Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment

Autor: Alexander N.W. Taylor, Robert Stahl, Katharina Buerger, Miguel Ángel Araque Caballero, Michael Ewers, Martin Dichgans, Lana Kambeitz-Ilankovic, Julia Hartmann, Daniel Janowitz, Lee Simon-Vermot, Birgit Ertl-Wagner, Claudia Mueller, Marco Duering, Nicolai Franzmeier, Cihan Catak

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's disease 59(4), 1381-1392 (2017). doi:10.3233/JAD-170360

Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc706eba81bd4cfa5af56bb7bd906fb0
https://doi.org/10.3233/jad-170360

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Autor: Nick C. Fox, Claudia Bartels, Henning Boecker, Peter R. Schofield, Stefan J. Teipel, Josef Priller, Peter Falkai, Michael Ewers, Michael T. Heneka, Stephen Salloway, Coraline D. Metzger, Jae-Hong Lee, Alfredo Ramirez, Michel J. Grothe, Anja Schneider, Colin L. Masters, Nicolai Franzmeier, Igor Yakushev, Oliver Peters, Eric McDade, Johannes Levin, Christoph Laske, Daniel Bittner, Agustín Ruiz, Michael Wagner, Gemma Monté-Rubio, Sonia Moreno-Grau, Miguel Ángel Araque Caballero, Felix Menne, Jason Hassenstab, Yen Ying Lim, Jens Wiltfang, Christian Haass, Anne M. Fagan, Frank Jessen, Marc Suárez-Calvet, Eike Jakob Spruth, Alison Goate, Adrian Danek, Manuel Fuentes, Octavio Rodríguez Gómez, Esther Milz, Christiana Franke, Brian A. Gordon, Robert Perneczky, Martin Dichgans, Martin N. Rossor, Klaus Fliessbach, Marco Duering, Tammie L.S. Benzinger, Celeste M. Karch, Peter J. Nestor, Frederic Brosseron, Jasmeer P. Chhatwal, Cihan Catak, Christine Westerteicher, Daniel Janowitz, Ingo Kilimann, Oliver Speck, Jinyi Ren, Katharina Buerger, Randall J. Bateman, Mercè Boada, Alexander Damm, Steffen Wolfsgruber, John C. Morris, Annika Spottke, Emrah Düzel

Publikováno v: Molecular psychiatry
Molecular psychiatry 26(2), 614-628 (2021). doi:10.1038/s41380-019-0404-6
Franzmeier, N, Ren, J, Damm, A, Monté-rubio, G, Boada, M, Ruiz, A, Ramirez, A, Jessen, F, Düzel, E, Rodríguez Gómez, O, Benzinger, T, Goate, A, Karch, C M, Fagan, A M, Mcdade, E, Buerger, K, Levin, J, Duering, M, Dichgans, M, Suárez-calvet, M, Haass, C, Gordon, B A, Lim, Y Y, Masters, C L, Janowitz, D, Catak, C, Wolfsgruber, S, Wagner, M, Milz, E, Moreno-grau, S, Teipel, S, Grothe, M J, Kilimann, I, Rossor, M, Fox, N, Laske, C, Chhatwal, J, Falkai, P, Perneczky, R, Lee, J, Spottke, A, Boecker, H, Brosseron, F, Fliessbach, K, Heneka, M T, Nestor, P, Peters, O, Fuentes, M, Menne, F, Priller, J, Spruth, E J, Franke, C, Schneider, A, Westerteicher, C, Speck, O, Wiltfang, J, Bartels, C, Araque Caballero, M Á, Metzger, C, Bittner, D, Salloway, S, Danek, A, Hassenstab, J, Yakushev, I, Schofield, P R, Morris, J C, Bateman, R J & Ewers, M 2019, ' The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0404-6

In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50ea03cf483f58c8dc9e6451ee25001
http://europepmc.org/articles/PMC6754794