The female lower genital tract is a privileged compartment with IL-10 producing dendritic cells and poor Th1 immunity following Chlamydia trachomatis infection.

Autor: Ellen Marks, Miguel A Tam, Nils Y Lycke

Publikováno v: PLoS Pathogens, Vol 6, Iss 11, p e1001179 (2010)

While a primary genital tract infection with C. trachomatis stimulates partial-protection against re-infection, it may also result in severe inflammation and tissue destruction. Here we have dissected whether functional compartments exist in the geni

Externí odkaz: https://doaj.org/article/2e3b1e4c0e404adf99ccf3d88a5624d0

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

Autor: Lisa Elmén, Dennie T. Frederick, Yibo Xian, Bas J. G. Baaten, Yan Li, Amir Orian, Hyungsoo Kim, Robert Schmaltz, Kevin M. Brown, Glenn Merlino, Roberto Tinoco, Eytan Ruppin, Ali Khateb, Ilanit Boyango, Avinash Das Sahu, Eva Guijarro Perez, Yongmei Feng, Randal J. Kaufman, Chi-Ping Day, Ze'ev Ronai, Tao Long, Lihi Tzur, Gil Bar-Sela, Emily Avitan-Hersh, Marcus Bosenberg, Shiri K. Ashkenazi, Mitchell P. Levesque, Shoshana Roizman, Linda M. Bradley, Raphy Zarecki, Yu Fujita, Scott N. Peterson, Colin R. Goding, Kerrie L. Marie, Reinhard Dummer, Rafael S. Segura Muñoz, Shibu Yooseph, Keith T. Flaherty, Tongwu Zhang, Amanda E. Ramer-Tait, Igor Segota, Miguel A. Tam

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Li, Y, Tinoco, R, Elmén, L, Segota, I, Xian, Y, Fujita, Y, Sahu, A, Zarecki, R, Marie, K L, Feng, Y, Khateb, A, Frederick, D T, Ashkenazi, S K, Kim, H, Pérez-Guijarro, E, Day, C-P, Segura Muñoz, R S, Schmaltz, R, Yooseph, S, Tam, M A, Zhang, T, Avitan-Hersh, E, Tzur, L, Roizman, S, Boyango, I, Bar-Sela, G, Orian, A, Kaufman, R J, Bosenberg, M, Goding, C R, Baaten, B, Levesque, M P, Dummer, R, Brown, K M, Merlino, G, Ruppin, E, Flaherty, K T, Ramer-Tait, A, Long, T, Peterson, S N, Bradley, L M & Ronai, Z A 2019, ' Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice ', Nature Communications, vol. 10, 1492, pp. 1-16 . https://doi.org/10.1038/s41467-019-09525-y
Nature Communications

Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034278988dcad7bc3424498560983469
https://doi.org/10.1038/s41467-019-09525-y

Plasmacytoid dendritic cells mature independently of MyD88 and IFN-αβR in response to Listeria and stimulate CD8 T cells

Autor: Ulf Alexander Wenzel, Miguel A. Tam, Mary Jo Wick

Publikováno v: Immunology Letters. 138:104-112

Plasmacytoid dendritic cells (pDCs) are a subpopulation of dendritic cells specialized in the production of IFN-α/β, particularly during viral infections. In this way pDCs directly impact antiviral immunity and influence T cell activation. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0c283ea681fb485ad11d18777d5bb7
https://doi.org/10.1016/j.imlet.2011.03.007

Early cellular responses toSalmonellainfection: dendritic cells, monocytes, and more

Autor: Miguel A. Tam, Anna Rydström, Mary Jo Wick, Malin Sundquist

Publikováno v: Immunological Reviews. 225:140-162

Dendritic cells (DCs), monocytes, macrophages, and neutrophils are myeloid-derived phagocytes critical to controlling bacterial infections, and these cells have complementary functions to ensure host survival. Recent data have shed light on the dynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d20ef274ba7fe402c8b3b5a9881473e
https://doi.org/10.1111/j.1600-065x.2008.00679.x

Synergy between CD40 and MyD88 does not influence host survival to Salmonella infection

Autor: Miguel A. Tam, María Fernández-Santoscoy, Mary Jo Wick, Pia Tegtmeyer, Ulf Alexander Wenzel

Publikováno v: Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology

Previous studies using purified toll-like receptor (TLR) ligands plus agonistic anti-CD40 antibodies showed that TLRs and CD40 can act synergistically on dendritic cells (DCs) to optimize T cell activation and Th1 differentiation. However, a synergis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1c6a8b027b2ecdca101b293c9c578d
http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00460/full